Microimaging System for Cancer Interventions

用于癌症干预的显微成像系统

基本信息

批准号：
7405849
负责人：
Jeremy J. Goeckeritz
金额：
$ 8.98万
依托单位：
STERLING RESEARCH CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-29 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7405849
关键词：
Ablation Address Ampulla of Vater Animal Testing Animals Area Barrett Esophagus Biological Biopsy Biopsy Specimen Bladder Bronchial Tree Caliber Cancer Intervention Catheters Clinical Clinical Research Coagulation Process Cochlea Collaborations Computer Systems Development Condition Data Data Display Detection Development Devices Diagnosis Diagnostic Diagnostic Procedure Disease Drug Delivery Systems Dyes Ear Early Diagnosis Economics Electrodes Endoscopes Endoscopy Engineering Environment Facility Construction Funding Category Fluorescence Spectroscopy Gastrointestinal tract structure General Anesthesia Hair Hospitalization Housing Human Human Resources IACUC Image In Situ In Vitro Individual Intervention Invasive Investigation Kidney Laboratories Laboratory Animals Lasers Left Left lung Legal patent Length Light Lighting Liquid substance Lung Malignant Neoplasms Malignant neoplasm of esophagus Marketing Mechanics Medical Monitor Nose Numbers Operative Surgical Procedures Optical Biopsy Optics Organ Outcome Pancreatic duct Patients Pattern Performance Personal Satisfaction Pharyngeal structure Phase Physicians Placement Postage Stamps Preparation Procedures Program Development Property Protocols documentation Radiofrequency Interstitial Ablation Range Rate Records Regulation Research Research Ethics Committees Resolution Retinal blind spot Route Safety Sampling Schedule Secure Small Intestines Specific qualifier value Specimen Squamous cell carcinoma Staging Sterilization for infection control System Technology Temporal bone structure Testing Therapeutic Therapeutic procedure Time Tissues Trauma recovery United States Food and Drug Administration Universities Upper digestive tract structure Utah Validation Visual Work abdominal wall base bile duct biomaterial compatibility cancer therapy clinical application commercialization cost design desire fluorescence imaging grasp improved in vivo instrumentation manufacturing process micromanipulator middle ear millimeter mortality next generation novel diagnostics optical fiber prototype quality assurance research clinical testing response scale up success tool visual control

项目摘要

DESCRIPTION (provided by applicant): Sarcos Research Corporation proposes clinical testing of a system for minimally-invasive diagnostic and interventional procedures in cancer, using an image-guided interventional system based on the Sarcos- developed microcamera and a steerable microcatheter. In this project, we propose to: (7) design the system packaging for performing interventional procedures, and (7) collaborate with the physicians in the investigation of diagnostic and therapeutic options where access to small and difficult to reach anatomical spaces under direct visual control is critical to the success of the therapy as well as to minimizing trauma, recovery time, length of hospitalization, and the need for general anesthesia. The system: (7) addresses the specific needs and constraints of minimally-invasive interventions that cannot be well met by conventional instrumentation, (7) increases safety of both minimally-invasive as well as traditional interventions by eliminating or minimizing the blind spots in the surgical field, (7) improves safety by enabling detailed visual observation of the operating field, (7) increases the availability of in-situ diagnostic procedures, (7) by virtue of disposability, eliminates current need for, and cost of endoscope cleaning and sterilizing, improving both patient's and operating personnel safety, (7) facilitates exploratory and diagnostic procedures, enabling earlier detection of disease and potentially earlier and less traumatic treatment. Initial clinical applications of the system will include otolaryngological procedures and examination of upper GIT. Phase 1 will result in prototype system development, laboratory characterization and the preparation of protocols for Phase 2 animal studies. Phase 2 will focus on the fabrication of clinical prototypes, animal and pilot clinical studies, and the development of final product, leading to large scale clinical testing, regulatory clearance/approval, and commercialization.

描述（由申请人提供）：Sarcos Research Corporation使用基于sarcos-开发的微型照射器和可呼吸的微型导管的图像引导的介入介绍系统，对癌症中最小侵入性诊断和介入程序进行临床测试。在该项目中，我们建议：（7）设计用于执行介入程序的系统包装，（7）与医生合作调查诊断和治疗方案，在此调查中，在直接视觉控制下，在直接直接达到解剖空间的诊断和治疗选择中对于治疗的成功以及最大程度地减少创伤，恢复时间，住院时间以及对全身麻醉的需求至关重要。系统：（7）解决了无法通过常规仪器很好地满足最小侵入性干预措施的特定需求和约束，（7）通过消除或最小化最小侵入性以及传统干预措施的安全性以及传统干预措施的安全性。手术领域，（7）通过启用对操作领域的详细视觉观察来提高安全性，（7）通过可用性来增加现场诊断程序的可用性，（7）消除当前对内窥镜清洁和成本的可用性（7）对患者和手术人员的安全进行灭菌，改善患者的安全性，促进探索性和诊断程序，从而能够早期发现疾病以及可能更早且较少的创伤性治疗。该系统的初始临床应用将包括耳鼻喉科程序和上GIT的检查。第1阶段将导致原型系统的发展，实验室表征和2阶段动物研究方案的制备。第2阶段将着重于制造临床原型，动物和试点临床研究以及最终产品的开发，从而导致大规模的临床测试，法规清除率/批准和商业化。