CTSA INFRASTRUCTURE FOR CLINICAL TRIALS

CTSA 临床试验基础设施

• 批准号: 7719837
• 负责人: HARRY SHAMOON
• 金额: $ 86.28万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-19 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719837
• 关键词: Clinical Trials; Research Infrastructure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This revised application (A2) responds to the CTSA initiative to establish and sustain an academic-community partnership for clinical and translational research/To achieve this goal, we created the Institute for Clinical and Translational Research (ICTR) founded on successful inter-dependent programs, including pediatric and adult patient research facilities, core laboratories, a K30 clinical research training program expanded to include a PhD n clinical investigation, and an NCRR K12 award for Career Development. The ICTR is jointly supported by the Albert Einstein College of Medicine, Yeshiva University and Montefiore Medical Center, and actively engages the communities comprising the 1.4 million ethnically diverse population of the Bronx. The ICTR also collaborates with regional and affiliated institutions, including the NYC Department of Health, the North Bronx Health Network, the Clinical Directors Network, Lehman College, and New Rochelle College of Nursing to expand research and training opportunities across the Bronx. The CTSA development process over the past 2 years has engaged a broad array of faculty from a number of disciplines (including medicine, dentistry, nursing, epidemiology, social work, and biomedical sciences) through these transformative partnerships. In parallel with developing Einstein's 2007 Strategic Research Plan, we 1) assessed the barriers within our institutions to cultivate inherent synergies; 2) initiated an Institution-wide process of forging interdisciplinary research linkages; 3) developed plans to consolidate existing infrastructure that supports clinical/translational research; 4) invested in new infrastructure- both physical facilities and programsthat support the CTSA mission; 5) unified the IRB review process; and 6) emphasized the training and nurturing a cohort of young investigators. The partners in this new Institute jointly provide tangible resources, including a new 200,000 nsf Center for Genetic and Translational Medicine, 30,000 nsf of space for ICTR programs and investigators, a joint Clinical Research Endowment fund, and matching funds to support translational technologies and scholars. The ICTR components are: a) Research Education, Training, and Career Development; b) Design, Biostatistics, and Research Ethics Resource; c) Participant and Clinical r Interaction Resources, including Adult and Pediatric Research Units; d) Community Engagement and Collaboration; e) Regulatory Knowledge and Support; f) Biomedical Informatics; g) Development; Novel Clinical/Translational Methodology "incubators" (Stem Cell Research, Biostatistical Methodologies, Behavioral/Social Science Research, and Epigenomics Research); h) Translational Technologies and Resources (MS Analytic Core, Biorepository, Biomarker Assay Core, Translational Genetics and Genomics Resource, and Cellular Therapeutics Laboratory); i) Pilot & Collaborative Projects; and j) Other key elements (shared facilities and cores, and transdisciplinary research programs). The mission of the ICTR is to enhance clinical and translational research by promoting multidisciplinary collaboration, addressing translational 'blocks' in research, providing infrastructure and collaborative support, and enhancing training, education, and career development.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项修订后的应用程序（A2）对CTSA倡议做出了旨在建立和维持临床和转化研究的学术社区伙伴关系/实现这一目标的伙伴关系，我们创建了基于成功的相互依存计划的临床和转化研究所（ICTR），包括儿科和成人研究设施，包括K30临床研究，包括K30的研究机构，包括临床研究，包括K30临床研究，包括K30的临床研究。用于职业发展。 ICTR由阿尔伯特·爱因斯坦医学院，Yeshiva大学和蒙特菲奥尔医学中心共同支持，并积极参与包括140万个族裔布朗克斯人口的社区。 ICTR还与区域和附属机构合作，包括纽约市卫生部，北布朗克斯健康网络，临床主管网络，雷曼学院和新罗切尔护理学院，以扩大布朗克斯的研究和培训机会。在过去的两年中，CTSA的发展过程已通过这些变革性伙伴关系从许多学科（包括医学，牙科，护理，流行病学，社会工作和生物医学科学）中参与了广泛的教师。与制定爱因斯坦（Einstein）的2007年战略研究计划的同时，我们1）评估了机构中培养固有协同作用的障碍； 2）启动了建立跨学科研究联系的机构范围的过程； 3）制定了巩固支持临床/转化研究的现有基础设施的计划； 4）投资于新的基础设施 - 支持CTSA任务的物理设施和计划； 5）统一IRB审查过程； 6）强调培训并培养一群年轻的调查员。这个新研究所的合作伙伴共同提供了切实的资源，包括新的200,000个NSF遗传和转化医学中心，30,000名ICTR计划和研究人员的NSF空间，一个联合临床研究捐赠基金，以及匹配的资金，以支持翻译技术和学者。 ICTR组成部分是：a）研究教育，培训和职业发展； b）设计，生物统计学和研究伦理资源； c）参与者和临床R相互作用资源，包括成人和儿科研究单位； d）社区参与与协作； e）监管知识和支持； f）生物医学信息学； g）发展；新颖的临床/转化方法“孵化器”（干细胞研究，生物统计学方法，行为/社会科学研究和表观基因组学研究）； h）翻译技术和资源（MS分析核心，生物库，生物标志物测定核心，转化遗传学和基因组学资源以及细胞治疗实验室）； i）飞行员与协作项目； j）其他关键要素（共享设施和核心以及跨学科研究计划）。 ICTR的使命是通过促进多学科的合作，解决研究中的翻译“块”，提供基础设施和协作支持，并增强培训，教育和职业发展，从而增强临床和转化研究。