Spatiotemporal Brain Imaging of Alcohol Effects on Inhibitory Control

酒精对抑制控制影响的时空脑成像

• 批准号: 7321706
• 负责人: KSENIJA MARINKOVIC
• 金额: $ 47.44万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-10 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7321706
• 关键词: Acute; Affect; Alcohol abuse; Alcohol dependence; Alcoholic Intoxication; Alcohols; Anterior; Area; Attenuated; Behavior; Behavioral; Brain; Brain imaging; Characteristics; Complex; Condition; Conflict (Psychology); Coupling; Cues; Dependence; Disruption; Dose; Electroencephalography; Electromagnetics; Evaluation; Exhibits; Feedback; Functional Magnetic Resonance Imaging; Gender; Goals; Heavy Drinking; Impairment; Individual; Intoxication; Investigation; Lateral; Magnetic Resonance Imaging; Magnetoencephalography; Manuals; Measures; Methods; Modality; Monitor; Motor; Movement; Multimodal Imaging; Nature; Output; Parietal; Pattern; Placebos; Preparation; Process; Research; Research Personnel; Research Project Grants; Resolution; Risk Factors; Role; Self-control as a personality trait; Signal Transduction; Specific qualifier value; Staging; Stimulus; Stream; System; Techniques; Time; Woman; Work; alcohol effect; alcohol sensitivity; cingulate cortex; cognitive control; design; drinking; goal oriented behavior; hazard; hemodynamics; indexing; men; neural circuit; neuroimaging; neurophysiology; problem drinker; programs; relating to nervous system; response; restraint; selective attention; spatiotemporal; stimulus processing; trafficking; trait

DESCRIPTION (provided by applicant): This is a revised application for an NIAAA-sponsored Research Project Grant (R01) entitled "Spatiotemporal Brain Imaging of Alcohol Effects on Inhibitory Control" Problem drinkers often exhibit deficits in self-control and sustained goal-oriented behavior. This observation is consistent with the evidence suggesting that acute intoxication interferes with the ability to evaluate conflicting task demands, inhibit impulsive responses and execute cognitive control. These impairments may result in a decreased ability to exert self restraint, contributing to increased drinking and alcohol dependence. The overall goal of the proposed research is to use multimodal brain imaging to identify the temporal ("when") and spatial ("where") characteristics of the neural circuits subserving inhibitory control and to determine their sensitivity to the acute effects of alcohol. Functional magnetic resonance imaging (fMRI) will be used in order to determine where the alcohol-induced induced changes are occurring. Excellent temporal resolution of magneto- (MEG) and electroencephalography (EEG) will elucidate the timing of these abnormalities. Effects of alcohol on both "input" (stimulus evaluation) and "output" (response preparation, inhibition and execution) will be studied concurrently and with the multimodal neuroimaging approach. It is hypothesized that alcohol intoxication primarily disrupts integrated prefrontal circuitry that exerts inhibitory top-down control on behavior. Since the strategic control is exerted via a complex system involving multiple stages of these integrated "input" and "output" streams in addition to error monitoring and regulatory feedback loops, multimodal imaging approach may reveal the real-time stages of the underlying neural areas and their sensitivity to alcohol intoxication. Healthy subjects will serve as their own controls as they participate in alcohol and placebo conditions in three tasks probing inhibitory control and selective attention. In addition, dispositional traits obtained in the same individuals will be considered together with the neurophysiological indices and may reveal the idiosyncratic aspects of alcohol effects on the brain and the multidimensional nature of inhibitory control. This research has ramifications for traffic- or work-related hazards and may elucidate the alcohol-induced impairment of self-regulatory functions contributing to alcohol abuse and dependence

描述（由申请人提供）：这是 NIAAA 资助的研究项目补助金 (R01) 的修订申请，题为“酒精对抑制控制的影响的时空脑成像” 有问题的饮酒者经常表现出自我控制和持续目标导向行为方面的缺陷。这一观察结果与表明急性中毒会干扰评估相互冲突的任务需求、抑制冲动反应和执行认知控制的能力的证据是一致的。这些损伤可能会导致自我克制能力下降，从而导致饮酒和酒精依赖增加。拟议研究的总体目标是使用多模式脑成像来识别有助于抑制控制的神经回路的时间（“时间”）和空间（“地点”）特征，并确定它们对酒精急性作用的敏感性。将使用功能磁共振成像（fMRI）来确定酒精引起的变化发生在哪里。磁图 (MEG) 和脑电图 (EEG) 的出色时间分辨率将阐明这些异常的发生时间。将同时使用多模式神经影像学方法研究酒精对“输入”（刺激评估）和“输出”（反应准备、抑制和执行）的影响。据推测，酒精中毒主要破坏了对行为进行自上而下的抑制性控制的整合前额叶回路。由于战略控制是通过一个复杂的系统来实现的，除了错误监控和调节反馈循环之外，还涉及这些集成“输入”和“输出”流的多个阶段，多模态成像方法可以揭示底层神经区域的实时阶段和他们对酒精中毒的敏感性。健康受试者将作为自己的对照，在酒精和安慰剂条件下参与三项探索抑制控制和选择性注意力的任务。此外，在同一个体中获得的性格特征将与神经生理学指标一起考虑，并可能揭示酒精对大脑影响的特殊方面以及抑制控制的多维性质。这项研究对交通或工作相关的危害有影响，并可能阐明酒精引起的自我调节功能受损，从而导致酒精滥用和依赖