Ten Year Longitudinal Analyses/Risk for Dental Caries in HIV Seropositive Women

艾滋病毒血清阳性女性的十年纵向分析/龋齿风险

基本信息

批准号：
7391312
负责人：
Stefanie L Russell
金额：
$ 7.61万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7391312
关键词：
Accounting Adherence Adverse effects Affect Behavior Behavioral CD4 Lymphocyte Count CD4/CD8 ratio procedure Caring Clinical Cocaine Cohort Studies Collection Data Data Quality Databases Demographic Factors Dental Dental Care Dental Hygiene Dental caries Development Disadvantaged Disease Drug usage Education Epidemiologist Ethnic Origin Factor Analysis Frequencies Gingival Recession Goals Grant HIV HIV Infections Health Highly Active Antiretroviral Therapy Illicit Drugs Incidence Income Individual Injection of therapeutic agent Interview Investigation Low income Matched Group Measurement Medical Methamphetamine Methodology Minority Minority Groups Nature Oral Oral health Outcome Parents Participant Pattern Personal Satisfaction Persons Pharmaceutical Preparations Plant Roots Preventive Provider Public Health Race Rate Recruitment Activity Research Research Personnel Research Project Grants Resources Risk Risk Factors Root Caries Saliva Salivary Secondary to Self Care Services Severity of illness Smoking Social Welfare Standards of Weights and Measures Statistical Data Interpretation Surface Time Tooth Diseases Treatment Protocols United States Viral Load result Woman disorder risk follow-up oral HIV patient home care prospective response size

项目摘要

DESCRIPTION (provided by applicant): It is well-established that dental caries (dental decay), one the most prevalent diseases in the United States, tends to disproportionably affect racial and ethnic minorities, and those who are economically and socially disadvantaged, and those with underlying medical problems. HIV+ persons are likely to be ethnic/racial minorities and are likely to be socio-economically disadvantaged, compared to HIV- persons. A recent 5-year investigation found that HIV infection was related to dental caries, but reasons for the disparity were unclear, and, perhaps most importantly, risk factors for caries within the HIV+ persons were not well defined as a result of this study. The objective of this proposed investigation is to clarify the relationship between HIV infection and dental caries. The Women's Interagency HIV Study (WIHS) and its oral sub-study (WIHS-OS) represent one of the largest studied cohorts of HIV+ persons in the United States, and provide the largest collection medical, interview and dental data of HIV+ persons followed for an extended period of time, beginning in 1995 and ending only recently (November, 2004). As part of the WIHS-OS, 844, primarily minority, women (719 HIV+, 125 HIV-) were recruited from the parent WIHS core in 1995-96; in 2001/02, in order to investigate the effects of HIV medications on a variety of outcomes, an additional 173 HIV+ women were added, for a total of 1017 women. Participants had interviews, medical and dental exams every six months. We propose to examine, using standard and appropriate statistical methodologies, using the WIHS and the WIHS-OS, whether demographic factors (income, education, race/ethnicity, drug use), behavioral factors (smoking, illicit drug use, use of dental services and oral self-care), HIV disease severity, HIV medication use, and oral health factors (saliva, oral hygiene and gum disease) are related to the development of caries over ten years. These proposed analyses are different from analyses that have been previously done because they will include data collected over the entire 10-year period of observation, from all women in the WIHS-OS and because they will include analysis of factors that have not previously been examined in this group. These analyses provide the best opportunity to resolve currently unanswered questions regarding the nature of caries in HIV+ persons, given the size of the database, the long, prospective nature of the follow-up for dental caries, and the high quality of the data. The results of these analyses will provide greatly needed clinical, practical, and public health information to dental and medical providers, as well as to those persons and agencies that are indebted to caring for the medical, dental and social welfare of persons with HIV infection. Recent studies have found that HIV infection may predispose persons to the development of dental decay (caries) due to side effects from medications and because of health damaging and health promoting behaviors in HIV+ persons. This proposed study is relevant because will resolve currently unanswered questions regarding the nature of caries in HIV+ persons. The results of these analyses will provide greatly needed clinical, practical, and public health information to dental and medical providers, as well as to those persons and agencies that are indebted to caring for the medical, dental and social welfare of persons with HIV infection.

描述（由申请人提供）：众所周知，龋齿（蛀牙）是美国最流行的疾病之一，往往对少数种族和族裔以及经济和社会弱势群体以及那些有潜在的医疗问题。与艾滋病毒感染者相比，艾滋病毒感染者可能是少数族裔/种族，并且可能在社会经济上处于不利地位。最近的一项为期五年的调查发现，艾滋病毒感染与龋齿有关，但造成这种差异的原因尚不清楚，也许最重要的是，这项研究的结果是，艾滋病毒+人群中龋齿的危险因素尚未得到明确定义。这项拟议调查的目的是澄清艾滋病毒感染与龋齿之间的关系。妇女机构间艾滋病毒研究 (WIHS) 及其口腔子研究 (WIHS-OS) 代表了美国最大的艾滋病毒+人群研究队列之一，并提供了继从 1995 年开始到最近（2004 年 11 月）才结束的一段较长的时间。作为 WIHS-OS 的一部分，1995-96 年从母体 WIHS 核心招募了 844 名女性（主要是少数族裔）（719 名 HIV+，125 名 HIV-）； 2001/2002 年，为了调查 HIV 药物对各种结果的影响，又增加了 173 名 HIV + 女性，总共 1017 名女性。参与者每六个月进行一次面谈、体检和牙科检查。我们建议使用标准和适当的统计方法，使用 WIHS 和 WIHS-OS，检查人口因素（收入、教育、种族/民族、吸毒）、行为因素（吸烟、非法吸毒、使用牙科服务）是否和口腔自我保健）、艾滋病毒疾病严重程度、艾滋病毒药物使用和口腔健康因素（唾液、口腔卫生和牙龈疾病）与十年来龋齿的发展有关。这些拟议的分析与以前进行的分析不同，因为它们将包括在整个 10 年观察期内从 WIHS-OS 中的所有女性收集的数据，并且因为它们将包括对以前未检查过的因素的分析在这个组中。考虑到数据库的规模、龋齿随访的长期性和前瞻性以及数据的高质量，这些分析为解决有关艾滋病病毒感染者龋齿性质的目前悬而未决的问题提供了最佳机会。这些分析的结果将为牙科和医疗提供者以及那些有义务照顾艾滋病毒感染者的医疗、牙科和社会福利的个人和机构提供急需的临床、实用和公共卫生信息。最近的研究发现，由于药物的副作用以及艾滋病毒阳性者的健康损害和健康促进行为，艾滋病毒感染可能使人容易患上蛀牙（龋齿）。这项拟议的研究具有相关性，因为它将解决目前尚未解答的有关艾滋病病毒感染者龋齿性质的问题。这些分析的结果将为牙科和医疗提供者以及那些有义务照顾艾滋病毒感染者的医疗、牙科和社会福利的个人和机构提供急需的临床、实用和公共卫生信息。