ADMINISTRATIVE CORE

行政核心

• 批准号: 7233109
• 负责人: BRIAN A. HERMAN
• 金额: $ 12.94万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7233109
• 关键词: Biogenesis; Biological Assay; Cell model; Cells; Complex; Consultations; Growth; Measures; Mitochondria; Mitochondrial DNA; Mitochondrial Proteins; Mitochondrial RNA; Participant; Ploidies; Principal Investigator; Production; Protein Biosynthesis; Research; Respiration; mitochondrial DNA mutation; novel strategies; programs; respiratory; respiratory enzyme; tool

Core C will serve as the Mitochondrial Function Core of the Program Project. Dr. Bai will serve as the Leader of Core C. Core C will be responsible for the following functions in the Program Project: 1. To provide tools and analytic approachesto study mitochondrial biogenesis including mitochondria! DMA content, mitochondrial RNA level, mitochondrial protein synthesis and respiratory complex assembly, and help to quantitatively detect the mitochondrial DMAmutations for all of the principal investigators of the program project who require such analysesfor the proposed studies. 2. To provide tools and approachesto analyze mitochondrialfunction including measuring total respiration, complex-dependent respiration, growth capacitywhile cells predominantly rely on mitochondria for ATP production and ATP level, and to perform respiratory enzymesassays and create mitochondrial DNA-less cell models for the principal investigators of the program projectwho require such analysesfor the proposed studies. 3. To provide consultation regarding the availability of existing and new approachesto study mitochondrial biogenesis and function to the participants of this program project and to insure the quality of relevant research conducted by the Projects and Cores.

核心C将作为程序项目的线粒体功能核心。 Bai博士将担任领导者 核心C的Core C将负责程序项目中的以下功能： 1。提供工具和分析方法研究线粒体生物发生，包括线粒体！ DMA 含量，线粒体RNA水平，线粒体蛋白合成和呼吸复合物组件，以及 有助于定量检测所有主要研究人员的线粒体DMAMUTATITS 需要对拟议研究进行此类分析的计划项目。 2。提供工具和方法分析线粒体函数，包括测量总呼吸， 复杂依赖性的呼吸，生长能力在主要依赖于ATP的线粒体 生产和ATP水平，并执行呼吸酶测定并创建线粒体DNA 该计划项目的主要研究人员的细胞模型，要求该提议的分析 研究。 3。提供有关现有和新方法的可用性的咨询 该计划项目的参与者的生物发生和功能，并确保相关的质量 项目和核心进行的研究。