NEUROBIOLOGY OF SLEEP AND SLEEP INTERVENTIONS IN THE ELDERLY

老年人睡眠的神经生物学和睡眠干预

• 批准号: 7432563
• 负责人: ERIC A. NOFZINGER
• 金额: $ 16.9万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7432563
• 关键词: Address; Adult; Age; Aging; Amygdaloid structure; Analysis of Variance; Anterior; Arousal; Attention; Behavioral; Bereavement; Brain; Cells; Cerebrum; Condition; Control Groups; Data; Deterioration; Disruption; Education; Educational Intervention; Effectiveness of Interventions; Elderly; Funding; Health; Hypothalamic structure; Intervention; Limbic System; Link; Maintenance; Measures; Medial; Medical; Metabolism; Morbidity - disease rate; Neuro-Oncological Ventral Antigen 2; Neurobiology; Personal Satisfaction; Play; Pontine structure; Positron-Emission Tomography; Posterior Hypothalamus; Prefrontal Cortex; Production; REM Sleep; Recruitment Activity; Reticular Formation; Risk; Role; Sleep; Slow-Wave Sleep; Stress; Structure; System; Thalamic structure; Time; Upper arm; age effect; age related; basal forebrain; caregiving; cingulate cortex; glucose metabolism; improved; mortality; sex; stressor; therapy design; young adult

Deteriorations in sleep are common in the elderly. These disturbances are associated with increased morbidity and mortality. Preliminary data suggest that some of these changes can be reversed with interventions designed to improve sleep. These reversals may be associated with improvements in health and well-being. The neurobiology of sleep and sleep interventions in the elderly however are unknown. This proposal will study regional cerebral glucose metabolism using [18F]-FDG PET during sleep before, and after interventions designed to improve sleep in 28 healthy elderly subjects. We propose that age-related declines in slow wave sleep will be associated with 1) age-related declines in prefrontal cortex metabolism, and 2) with age-related increases in metabolism in brain structures linked with behavioral arousal. These include the ascending reticular activating system and limbic and paralimbic structures known to modulate this system. We also propose that changes in REM sleep during aging result from: 1) increased metabolism in brain structures related to behavioral arousal (pontine reticular formation, basal forebrain, posterior hypothalamus, amygdala, thalamus and ventromedial prefrontal cortex), and 2) decreased metabolism in anterior paralimbic structures (anterior cingulate cortex and medial prefrontal cortex) and in prefrontal cortex. Eighteen months of mild sleep restriction and sleep education will result in less severe deterioration in age-related sleep neurobiology than will an attention-only control condition. In order to address these hypotheses we will perform neurobiological studies of sleep in 33 elderly subjects (greater than or equal to 75 yrs) at baseline and following either an 18-month sleep restriction + sleep education intervention (n=14) or an 18-month attention-only (n=14) control period. Comparisons between elderly pre-intervention measures with those of a sex-matched young adult control group (ages 25-45 yrs) will assess the effects of age. Group (intervention vs control) by time (pre- vs. post-intervention) interactions in a repeated measures ANOVA will assess the effects of the sleep intervention. Analysis of the main effect of time in this analysis will assess within-subject effects of aging.

睡眠恶化在老年人中很常见。这些干扰与发病率和死亡率的增加有关。初步数据表明，其中一些更改可以通过旨在改善睡眠的干预措施来逆转。这些逆转可能与健康和福祉的改善有关。然而，老年人的睡眠和睡眠干预的神经生物学尚不清楚。该建议将在睡眠期间和旨在改善28名健康老年受试者睡眠的干预措施后使用[18F] -FDG PET研究区域脑葡萄糖代谢。我们建议与年龄相关的慢波睡眠下降将是 与1）与年龄相关的前额叶皮质代谢中的下降以及2）与行为唤醒有关的脑结构中与年龄相关的代谢增加。这些包括升序的网状激活系统以及已知可调节该系统的边缘和旁白结构。我们还提出，衰老期间REM睡眠的变化来自以下原因：1）与行为唤醒有关的大脑结构中的代谢增加（庞然网状形成，基础前脑，下丘脑后下丘脑，杏仁核，thalamus和腹膜前乳状细胞中的杏仁核），以及2）降低了降低的代谢。前旁边结构（前扣带回皮层和 内侧前额叶皮层）和前额叶皮层。长达18个月的轻度睡眠限制和睡眠教育将导致年龄相关的睡眠神经生物学恶化较严重，而不是关注的控制状况。 为了解决这些假设，我们将在基线时对33名老年受试者（大于或等于75年）进行睡眠的神经生物学研究，并在18个月的睡眠限制 +睡眠教育干预（n = 14）或18--之后每月关注（n = 14）控制期。老年人干预措施与性别匹配的年轻成人对照组（25 - 45岁）的比较将评估年龄的影响。按时间（干预与对照）按时间（干预后与干预后）相互作用，反复措施ANOVA将评估 睡眠干预。在此分析中对时间的主要影响分析将评估受试者内衰老的影响。