PROJECT/ EXPLORATORY STUDIES CORE

项目/探索性研究核心

• 批准号: 7424120
• 负责人: Terri R. Fried
• 金额: $ 29.65万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7424120
• 关键词: Affect; American; Applications Grants; Basic Science; Biostatistics Core; Clinical; Collaborations; Condition; Data; Development; Diagnosis; Elderly; Enrollment; Ensure; Etiology; Funding; Goals; Health; Informatics; Intervention; Intervention Studies; Monitor; Other Resources; Precipitating Factors; Prevention; Research; Research Design; Research Personnel; Research Proposals; Resources; Safety; Underrepresented Minority; career; cost; data management; human subject; innovation; research study

The primary goal of the Pilot/Exploratory Studies Core (PESC) is to facilitate the development of innovative and methodologically rigorous research studies designed to enhance our understanding of the etiology, diagnosis, treatment, and prevention of multifactorial geriatric health conditions (the stated focus of the Yale OAIC.1), leading ultimately to the development of efficacious and cost-effective interventions to increase or maintain independence for older Americans. The specific aims are: (1) to solicit and select the most meritorious research proposals for PESC funding; (2) to provide investigators of PESC studies with access to resources from the other OAIC Cores; (3) to identify potential opportunities for co-sponsorship of PESC studies; (4) to identify potential opportunities for collaboration among PESC investigators; (5) to monitor the progress of the PESC studies; (6) to provide assistance so that the PESC studies can be successfully developed into independently funded grant applications; (7) to ensure the safety and protection of human subjects enrolled in PESC studies; and (8) to ensure that PESC studies enroll a substantial proportion of underrepresented minorities. The PESC will provide an invaluable mechanism for investigators to obtain preliminary data for promising basic science, translational, clinical, epidemiologic and intervention studies taking a multifactorial approach to the study of geriatric health conditions. Such studies investigate the interactions among or intervene on the multiple predisposing and precipitating factors that are responsible for many of the health conditions affecting older persons, which, in turn, have effects on multiple domains of health..Studies funded through the PESC will take full advantage of the resources and expertise available from the Field, Data Management & Informatics, and Biostatistics Cores. Priority for PESC funding will be given to junior investigators as well as to accomplished mid career and senior investigators who wish to redirect or expand their research to the study of multifactorial geriatric health conditions.

试点/探索性研究核心（PESC）的主要目标是促进创新技术的发展 以及旨在增强我们对病因学的理解的方法论严谨的研究， 多因素老年健康状况的诊断、治疗和预防（耶鲁大学的既定重点 OAIC.1)，最终导致制定有效且具有成本效益的干预措施，以增加或 保持美国老年人的独立性。具体目标是： (1) 征集并选择最有价值的研究计划以获得PESC资助； (2) 为 PESC 研究的研究者提供获取其他 OAIC 核心资源的途径； (3) 确定共同赞助 PESC 研究的潜在机会； (4) 确定 PESC 研究人员之间合作的潜在机会； (5) 监测PESC研究进展； (6) 提供协助，使PESC研究能够成功发展为独立资助的 补助金申请； (7) 确保参与 PESC 研究的人类受试者的安全和保护；和 (8) 确保 PESC 研究纳入相当比例的代表性不足的少数群体。 PESC 将为研究人员提供一个宝贵的机制，以获得有希望的初步数据 采用多因素方法的基础科学、转化、临床、流行病学和干预研究 对老年人健康状况的研究。此类研究调查之间的相互作用或干预 导致许多健康状况的多种诱发因素和诱发因素 影响老年人，进而对健康的多个领域产生影响。通过资助的研究 PESC 将充分利用现场、数据管理方面的资源和专业知识 ＆信息学和生物统计学核心。 PESC 资助也将优先考虑给初级研究人员 对于那些希望将研究重定向或扩展至以下领域的有成就的职业中期和高级研究人员 多因素老年健康状况的研究。