Genetic Epidemiology of Youth Conduct Problems

青少年行为问题的遗传流行病学

基本信息

批准号：
7161310
负责人：
Benjamin B Lahey
金额：
$ 34.88万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-01-01 至 2008-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7161310
关键词：
21 year old Academic achievement Accounting Address Adolescence Adolescent Adult Age Animals Behavior Behavioral Genetics Child Childhood Cognitive Communities Data Data Analyses Development Environmental Risk Factor Exposure to Family Family Characteristics Family member Female First Births Fostering Foundations Future Generations Genetic Human Income Interview Knowledge Link Longitudinal Studies Longitudinal Surveys Maternal Age Measures Mediating Menarche Methods Modeling Mothers Neighborhoods Nicotine Numbers Participant Pathway interactions Perinatal Exposure Policies Population Density Pregnancy Prevention Problem behavior Public Health Public Policy Research Personnel Risk Sampling Schools Sex Characteristics Siblings Social Disorganizations Socioeconomic Status Standards of Weights and Measures System Temperament Testing Time Woman Youth adolescent delinquent behavior base early childhood elementary school genetic analysis genetic epidemiology improved maternal cigarette smoking neurodevelopment prenatal programs sex social cognitive theory theories tool youth conduct problem

项目摘要

DESCRIPTION (provided by applicant): Youth conduct problems are a serious public health concern, but little progress has been made in understanding their causes. This proposal addresses the genetic epidemiology of youth conduct problems to advance knowledge of their causes. We propose to analyze data from the National Longitudinal Study of Youth, which is a nationally-representative sample of 14-21 year olds first interviewed in 1979 (NLSY79). The NLSY79 includes 4,926 females who are now 37-45 years old. Since 1986, assessments have been conducted of all offspring of these women (Children of NLSY79 Study). Longitudinal data are now available on child conduct problems from ages 4 through 11 years for 5,122 offspring and on delinquent behavior through adolescence for 2,590 offspring. Because the participants are both vertically related (mother and offspring) and horizontally related (full siblings, half-siblings, etc.), their kinship links allow us to use behavior genetic methods to study genetic and environmental influences on youth conduct problems. We will test hypotheses derived from a causal model of the origins of conduct problems that integrates hypotheses from social learning theory, developmental theory, and behavior genetics. Our model shares T. E. Moffitt's assertion that the causes of adolescent delinquency are different for youth who follow different developmental pathways. We will provide the first strong test of this fundamental hypothesis by determining if genetic and environmental influences on adolescent delinquency vary as a function of the youth's level of conduct problems during childhood. We will examine sex differences in the development of conduct problems and test for possible sex differences in causal influences. Behavior genetic analyses typical treat environmental influences as anonymous, but we will estimate the extent to which a number of maternal, family, and community variables, which are important to both scientific theory and public policy, are causally related to youth conduct problems through genetic and environmental correlations. These include maternal age at first birth, maternal smoking during pregnancy, family socioeconomic status, neighborhood socioeconomic status, neighborhood social disorganization, and urbanicity.

描述（由申请人提供）：青少年行为问题是一个严重的公共卫生问题，但在了解其原因方面进展甚微。该提案解决了青少年行为问题的遗传流行病学问题，以增进对其原因的了解。我们建议分析来自全国青少年纵向研究的数据，该研究是 1979 年首次采访的具有全国代表性的 14-21 岁青少年样本 (NLSY79)。 NLSY79 包括 4,926 名年龄在 37-45 岁之间的女性。自 1986 年以来，对这些妇女的所有后代进行了评估（NLSY79 研究的儿童）。现在可以获得 5,122 名后代 4 岁至 11 岁儿童行为问题的纵向数据，以及 2,590 名后代整个青春期犯罪行为的纵向数据。由于参与者既有纵向相关（母亲和后代）又有横向相关（同父异母的兄弟姐妹、同父异母的兄弟姐妹等），他们的亲属关系使我们能够利用行为遗传学方法来研究遗传和环境对青少年行为问题的影响。我们将检验源自行为问题起源的因果模型的假设，该模型整合了社会学习理论、发展理论和行为遗传学的假设。我们的模型认同 T. E. Moffitt 的观点，即对于遵循不同发展道路的青少年来说，青少年犯罪的原因是不同的。我们将通过确定遗传和环境对青少年犯罪的影响是否随青少年犯罪水平的变化而变化，从而对这一基本假设进行首次强有力的检验。童年时期的品行问题。我们将检查行为问题发展中的性别差异，并测试因果影响中可能存在的性别差异。行为遗传分析通常将环境影响视为匿名，但我们将通过遗传和遗传来估计对科学理论和公共政策都很重要的许多母亲、家庭和社区变量与青少年行为问题之间的因果关系。环境相关性。这些包括母亲第一胎年龄、母亲怀孕期间吸烟、家庭社会经济地位、社区社会经济地位、社区社会解构和城市化。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Population density and youth antisocial behavior.

人口密度和青少年反社会行为。

DOI：
发表时间：
2009-08
期刊：
影响因子：
0
作者：
Harden, K Paige;D'Onofrio, Brian M;Van Hulle, Carol;Turkheimer, Eric;Rodgers, Joseph L;Waldman, Irwin D;Lahey, Benjamin B
通讯作者：
Lahey, Benjamin B

A quasi-experimental analysis of the influence of neighborhood disadvantage on child and adolescent conduct problems.

邻里劣势对儿童青少年行为问题影响的准实验分析。

DOI：
10.1037/a0025078
发表时间：
2012-02
期刊：
Journal of abnormal psychology
影响因子：
4.6
作者：
Goodnight JA;Lahey BB;Van Hulle CA;Rodgers JL;Rathouz PJ;Waldman ID;D'Onofrio BM
通讯作者：
D'Onofrio BM

Smoking during pregnancy and offspring externalizing problems: an exploration of genetic and environmental confounds.

怀孕期间吸烟和后代外化问题：对遗传和环境混杂因素的探索。

DOI：
发表时间：
2008
期刊：
影响因子：
3.3
作者：
D'Onofrio, Brian M;Van Hulle, Carol A;Waldman, Irwin D;Rodgers, Joseph Lee;Harden, K Paige;Rathouz, Paul J;Lahey, Benjamin B
通讯作者：
Lahey, Benjamin B

Temperament and parenting during the first year of life predict future child conduct problems.

生命第一年的气质和养育方式可以预测未来孩子的行为问题。

DOI：
发表时间：
2008-11
期刊：
影响因子：
3.6
作者：
Lahey, Benjamin B;Van Hulle, Carol A;Keenan, Kate;Rathouz, Paul J;D'Onofrio, Brian M;Rodgers, Joseph Lee;Waldman, Irwin D
通讯作者：
Waldman, Irwin D

Specification, testing, and interpretation of gene-by-measured-environment interaction models in the presence of gene-environment correlation.

在存在基因-环境相关性的情况下，对基因与测量环境相互作用模型进行规范、测试和解释。