Risk Factors for Psychopathology in the WHO WMH Surveys

世界卫生组织 WMH 调查中的精神病理学危险因素

基本信息

批准号：
7261959
负责人：
RONALD C KESSLER
金额：
$ 97.27万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-07-20 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7261959
关键词：
Abuse Reporting Address Adult Age Age at Menarche Agoraphobia Alcohols Anthropology Anxiety Anxiety Disorders Area Attention deficit hyperactivity disorder Behavior Bipolar Disorder Borderline Personality Disorder Calibration Canada Caregivers Castes Causations Child Childhood China Clinical Collaborations Colombia Communities Complication Country County Couples Cuba DSM-IV Data Data Analyses Data Collection Data Set Databases Dependence Diagnosis Diagnostic Disease Divorce Drug abuse Dysthymic Disorder Education Employment Epidemiologist Epidemiology Exposure to Factor Analysis Family Female Funding Generalized Anxiety Disorder German population Government Health Surveys Impulse Control Disorders Income India Individual Informed Consent Intermittent Explosive Disorders International International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10)Interview Interviewer Investigation Investments Japanese Population Language Laws Long-Term Effects Marriage Measures Medical Mental Health Mental disorders Monitor Mood Disorders Needs Assessment Nepal New Zealand Nicotine Dependence Northern Ireland Numbers Obsessive-Compulsive Disorder Occupations Oppositional Defiant Disorder Oral Contraceptives Outcome Ownership Panic Panic Disorder Pathological Gambling Pattern Personal Satisfaction Personality Disorders Population Positioning Attribute Postdoctoral Fellow Pregnancy Prevalence Principal Investigator Probability Production Prohibit Property Rights Prospective Studies Psychopathology Psychotic Disorders Published Comment Quality Control Range Rate Recording of previous events Registries Reporting Reproductive Health Research Research Personnel Residual state Resources Respondent Retrospective Studies Risk Factors Role Sample Size Sampling Scanning Sex Characteristics Site Social Class Social Phobia Societies South Africa Specific Phobia Structure Substance Use Disorder Surveys System Thinking Time Training Traumatic Stress Disorders Ukraine Variant Woman World Bank World Health Organization Writing Youth abuse victim anti social authority birth control comparative cost design instrument interest intergenerational medical schools men neglect parity programs prospective response single episode major depressive disorder size social

项目摘要

DESCRIPTION (provided by applicant): This proposal is a second resubmission of an earlier proposal that was submitted in response to PA-03-044 (Risk Factors for Psychopathology Using Existing Data Sets) to carry out comprehensive centralized secondary analyses of risk factors in the World Health Organization World Mental Health (WMH) surveys. The WMH surveys are a coordinated set of community psychiatric epidemiological surveys in 28 countries with a combined sample size of over 214,000 respondents. The diagnostic instrument is an expanded version of the WHO Composite International Diagnostic Interview (CIDI). The interviews also include a rich risk factor battery. The surveys are all being carried out by carefully trained and closely monitored lay interviewers, with centralized training and quality control monitoring used to maximize comparability of data across sites. Clinical reappraisal interviews using the Structured Clinical Interview for DSM-IV (SCID) are being administered to sub-samples in a number of sites to confirm the CIDI diagnoses. Most of the 28 surveys are funded only to assess the within-county societal burden of mental disorders, unmet needs for treatment, and barriers to obtaining treatment. Within-country analyses are largely limited to preparing government reports on these basic issues. None of the survey teams is funded to carry out cross-national comparative analyses. We propose to capitalize on this under-use of the WMH survey data by carrying out centralized secondary analyses in collaboration with the international WMH investigators. These secondary analyses will focus on three lines of research, all of which have been of long-standing interest to psychiatric epidemiologists: (1) sex differences in mental illness; (2) the association between social class and mental illness; and (3) the long-term effects of childhood adversities on adult mental illness. The unprecedented size and substantive richness of the WMH database will allow important contributions to be made in each of these three areas of investigation. Three major changes have been made in response to reviewer comments. First, the number of originally proposed lines of investigation was reduced from six to three. Second, we added a second FTE medical anthropology postdoctoral fellow and a senior medical anthropologist Co-Investigator to the team. Third, the level of detail in the description of data analysis plans has been substantially expanded in this revised submission in response to reviewer comments.

描述（由申请人提供）：本提案是针对 PA-03-044（使用现有数据集的精神病理学风险因素）提交的早期提案的第二次重新提交，旨在对患者中的风险因素进行全面的集中二次分析。世界卫生组织世界心理健康 (WMH) 调查。 WMH 调查是在 28 个国家进行的一系列社区精神病学流行病学调查，总样本量超过 214,000 名受访者。该诊断工具是世界卫生组织综合国际诊断访谈（CIDI）的扩展版本。访谈还包括丰富的风险因素。所有调查均由经过精心培训和严密监控的非专业访谈员进行，并采用集中培训和质量控制监控来最大限度地提高跨站点数据的可比性。正在使用 DSM-IV 结构化临床访谈 (SCID) 对多个地点的子样本进行临床重新评估访谈，以确认 CIDI 诊断。 28 项调查中的大多数仅用于评估县内精神障碍的社会负担、未满足的治疗需求以及获得治疗的障碍。国内分析主要限于准备有关这些基本问题的政府报告。没有一个调查小组获得资助来进行跨国比较分析。我们建议与国际 WMH 研究人员合作进行集中二次分析，以利用 WMH 调查数据利用不足的情况。这些二次分析将集中于三个研究领域，所有这些研究领域长期以来一直引起精神病学流行病学家的兴趣：（1）精神疾病的性别差异； (2)社会阶层与精神疾病之间的关联； (3) 童年逆境对成年精神疾病的长期影响。 WMH 数据库前所未有的规模和实质性丰富性将使我们能够在这三个研究领域中的每一个领域做出重要贡献。根据审稿人的意见，进行了三项重大更改。首先，原定的调查路线从6条减少到3条。其次，我们在团队中增加了第二位 FTE 医学人类学博士后研究员和一位高级医学人类学家联合研究员。第三，根据审稿人的意见，在修改后的提交中，数据分析计划描述的详细程度得到了大幅扩展。