Admixture Mapping for Insulin Complex Outcomes

胰岛素复合结果的混合图

基本信息

批准号：
7221277
负责人：
JOSE R FERNANDEZ
金额：
$ 30.25万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-07-01 至 2009-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7221277
关键词：
Accounting Acute Admixture African American Age-Years American Area Biological Blood Body Composition Characteristics Child Chromosomes, Human, Pair 1 Classification Complex Condition DNA Sequence Data Development Diabetes Mellitus Disease Eating Energy Intake Energy Metabolism Environment Environmental Risk Factor Epidemiologic Studies Ethnic group European Evolution Exposure to Fasting Female Future Genes Genetic Genetic Markers Genome Genotype Glucose Hispanic Americans Hour Human Incidence Individual Insulin Intervention Investigation Maps Measures Metabolic syndrome Modeling Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Outcome Measure Phase Phenotype Physical activity Population Predisposition Prevalence Prevention strategy Principal Investigator Proxy Puberty Questionnaires Race Reporting Risk Risk Factors Role Sampling Socioeconomic Status Testing Variant boys diabetes risk diabetic girls insight insulin secretion insulin sensitivity preference prevent racial and ethnic racial difference racial/ethnic difference response tool development trait

项目摘要

DESCRIPTION (provided by applicant): Racial and ethnic differences in the incidence of diabetes have been identified in epidemiological studies. Although recent investigations have associated genetic markers and environmental factors contributing to the diabetes-related phenotypes within populations, the extent to which these factors in fact account for racial/ethnic differences is still unclear. The main objective of this study is to investigate the effect of genetic and environmental parameters on racial/ethnic differences in diabetes-related traits by modeling individual estimates of genetic admixture and environmental measures of energy intake, energy expenditure and socioeconomic status (SES) on measures of fasting insulin, sensitivity to insulin and initial phase of insulin secretion after exposure to glucose. A sample of 120 African-American (AA), 120 European-American (EA) and 120 Hispanic-American (HA) boys and girls of 7-13 years of age will be tested to obtain outcomes of insulin action and response, body composition, energy intake and energy expenditure to questionnaire and SES. The specific aims of this investigation are: (a) To test the role of European genetic admixture on diabetes-related measures of fasting insulin (FI), insulin sensitivity (Si) and insulin response to glucose (AIRg) after adjusted for body composition parameters (2) To investigate how the relationship between the environmental parameters energy intake, energy expenditure and socioeconomic status differ as a function of admixture and diabetes-related measures of fasting insulin (FI), insulin sensitivity (Si) and insulin response to glucose (AIRg), and (3) To test phenotype-genotype associations between ancestry-informative markers (AIMs) and measures of FG, Si and AIRg after adjusted for body composition and environmental parameters in a sample of AA, HA and EA prepubertal children. The proposed investigation will provide meaningful and important insight into the understanding of biological, non-biological and the interaction of both components in racial/ethnic differences in diabetes-related traits. Furthermore, the results of this investigation will serve as a tool for the development of effective preventive strategies to reduce the prevalence of diabetes and its related traits in racial/ethnic populations.

描述（由申请人提供）：流行病学研究已经确定了糖尿病发病率的种族和民族差异。尽管最近的研究将遗传标记和环境因素与人群中糖尿病相关表型相关，但这些因素实际上在多大程度上解释了种族/民族差异仍不清楚。本研究的主要目的是通过对基因混合的个体估计和能量摄入、能量消耗和社会经济地位（SES）的环境测量进行建模，研究遗传和环境参数对糖尿病相关性状的种族/民族差异的影响。空腹胰岛素、胰岛素敏感性和暴露于葡萄糖后胰岛素分泌的初始阶段。将对 120 名 7-13 岁的非洲裔美国人 (AA)、120 名欧洲裔美国人 (EA) 和 120 名西班牙裔美国人 (HA) 男孩和女孩进行测试，以获得胰岛素作用和反应、身体成分的结果、能量摄入和能量消耗到问卷和 SES。本研究的具体目的是： (a) 在调整身体成分参数后，测试欧洲基因混合物对空腹胰岛素 (FI)、胰岛素敏感性 (Si) 和胰岛素对葡萄糖的反应 (AIRg) 等糖尿病相关指标的作用(2) 研究环境参数能量摄入、能量消耗和社会经济状况之间的关系如何随着空腹胰岛素 (FI)、胰岛素敏感性 (Si) 和胰岛素对葡萄糖的反应 (AIRg) 的混合和糖尿病相关测量值的变化而变化。 ), (3) 测试在 AA、HA 和 EA 青春期前儿童样本中，根据身体成分和环境参数进行调整后，祖先信息标记 (AIM) 与 FG、Si 和 AIRg 测量值之间的表型-基因型关联。拟议的研究将为理解糖尿病相关特征的种族/民族差异中的生物、非生物以及这两种成分的相互作用提供有意义且重要的见解。此外，这项调查的结果将作为制定有效预防策略的工具，以减少种族/族裔人群中糖尿病及其相关特征的患病率。