UNCOVERING HIDDEN IN VIVO RESONANCES USING EDITING BASED

使用基于编辑的方法揭示隐藏的体内共振

• 批准号: 7181948
• 负责人: MALGORZATA MARJANSKA
• 金额: $ 2.49万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7181948
• 关键词: bioimaging /biomedical imaging; biomedical equipment resource; biomedical resource; clinical research; human subject; magnetic resonance imaging; method development; nuclear magnetic resonance spectroscopy

DESCRIPTION (provided by applicant): Center for Magnetic Resonance Research at the University of Minnesota is an interdepartmental and interdisciplinary research laboratory that has been funded as a Biotechnology Research Resource (BTRR) during the last nine years. The central research focus of this BTRR is development and improvement of methodologies and technologies for high magnetic resonance (MR) imaging and spectroscopy, and providing state-of-the-art instrumentation, expertise and infrastructure to enable the faculty, trainees and staff of several institutions in the USA and abroad to carry out basic and applied biomedical research that utilizes these unique high magnetic field (4 to 9.4 Tesla) capabilities. The general aim of this application is to seek continued support for this Biomedical Technology Research Resource so as to pursue new methodological and technical developments and maintain a National Research Resource with unique instrumentation and expertise that is not readily available elsewhere. A central and primary aim of the Core projects is to develop techniques for obtaining simultaneous information on aspects of organ function, perfusion, oxygen extraction, metabolism, and anatomy in humans non-invasively, using the unique advantages provided by high magnetic fields, such as the high signal-to-noise ratio, increased susceptibility effects associated with blood for imaging brain function, longer Tls for measurement of tissue perfusion, increased chemical-shift resolution for improved detection of neurochemicals, and the use of magnetic isotopes of biologically active atoms, such as O-17, which are not accessible easily at low magnetic fields due to their low gyromagnetic ratio. These techniques have been and will continue to be utilized to support a large community of NIH funded researchers working in neurosciences, functional brain mapping, brain metabolism, metabolic disorders, and cardiac pathology and bioenergetics.

描述（由申请人提供）： 明尼苏达大学磁共振研究中心是一个跨部门、跨学科的研究实验室，在过去九年中一直受到生物技术研究资源 (BTRR) 的资助。该 BTRR 的中心研究重点是开发和改进高磁共振 (MR) 成像和光谱学的方法和技术，并提供最先进的仪器、专业知识和基础设施，使多个机构的教职人员、学员和工作人员能够美国和国外的机构利用这些独特的高磁场（4 至 9.4 特斯拉）能力开展基础和应用生物医学研究。本申请的总体目标是寻求对该生物医学技术研究资源的持续支持，以追求新的方法和技术发展，并维持具有其他地方不易获得的独特仪器和专业知识的国家研究资源。核心项目的核心和主要目标是开发技术，利用高磁场提供的独特优势，以非侵入方式同时获取人体器官功能、灌注、氧气提取、新陈代谢和解剖学方面的信息，例如高信噪比、与血液相关的敏感性效应增加（用于脑功能成像）、用于测量组织灌注的较长 Tls、用于改进神经化学物质检测的化学位移分辨率的提高以及生物活性原子磁性同位素的使用，这样的例如 O-17，由于其旋磁比低，在低磁场下不易接近。这些技术已经并将继续用于支持 NIH 资助的大型研究人员社区，这些研究人员从事神经科学、功能性脑图谱、脑代谢、代谢紊乱以及心脏病理学和生物能量学方面的工作。