MRI measures of neural connectivity in Asperger's Disorder

亚斯伯格症神经连接的 MRI 测量

基本信息

批准号：
7530053
负责人：
Scott James Peltier
金额：
$ 18.63万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-01 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7530053
关键词：
Adolescence Amygdaloid structure Anterior Area Asperger Syndrome Autistic Disorder Automobile Driving Biological Brain Community Integration Complement Condition Control Groups Development Diffusion Magnetic Resonance Imaging Disease Emotional Family Functional Imaging Functional Magnetic Resonance Imaging Goals Hippocampus (Brain)Imaging Techniques Individual Knowledge Longitudinal Studies Magnetic Resonance Imaging Measures Medial Mental Health Neurobiology Nonverbal Communication Outcome Public Health Recording of previous events Research Research Personnel Resources Rest Role Social Development Symptoms Syndrome Techniques Theoretical model Therapeutic Ursidae Family Work age group age related autism spectrum disorder base cingulate cortex cognitive system cohort early childhood gray matter innovation neuroimaging novel diagnostics peer relating to nervous system social social cognition white matter

项目摘要

DESCRIPTION (provided by applicant): Subjects with Asperger's Disorder have deficits in social cognition, which may be due to abnormal brain connectivity (Belmonte, et al. 2004; Welchew, et al. 2005). Using a battery of advanced MRI techniques, we propose a study to examine anatomical and structural connectivity in a group of 40 subjects with Asperger's Disorder and 40 matched controls, focusing on limbic/paralimbic areas associated with social cognition (including the anterior and posterior cingulate, amygdala, and hippocampus). This line of research is motivated by our preliminary work showing alterations in resting-state functional connectivity networks between subjects with Asperger's Disorder and healthy controls. Our specific aims are: 1) to use functional connectivity to examine resting-state network differences; 2) to use diffusion tensor imaging (DTI) to examine white matter integrity; and 3) to examine developmental effects between age groups and cohorts. This study will give us a clearer picture of the neurobiology of Asperger's Disorder, and can form the basis for extensions to Autism Spectrum Disorders (ASD). The unique capabilities and resources available to the primary investigators allow for an excellent opportunity to carry out this innovative work. PUBLIC HEALTH RELEVANCE: This project will investigate the social deficits in Asperger's Disorder using magnetic resonance imaging (MRI) to examine measures of brain connectivity. The results will further knowledge about the biological consequences of this condition, and possibly help to develop new diagnostic or therapeutic techniques.

描述（由申请人提供）：阿斯伯格症患者存在社会认知缺陷，这可能是由于大脑连接异常所致（Belmonte 等人，2004 年；Welchew 等人，2005 年）。我们利用一系列先进的 MRI 技术，提出了一项研究，检查 40 名患有阿斯伯格症的受试者和 40 名匹配对照者的解剖学和结构连接性，重点关注与社会认知相关的边缘/副边缘区域（包括前扣带回和后扣带回、杏仁核和海马体）。我们的初步工作显示了阿斯伯格症患者和健康对照者之间静息态功能连接网络的变化，这一系列研究的动机是这样的。我们的具体目标是：1）使用功能连接来检查静息状态网络差异； 2）利用弥散张量成像（DTI）检查白质完整性； 3) 检查年龄组和群体之间的发育影响。这项研究将使我们对阿斯伯格症的神经生物学有更清晰的认识，并可以为自闭症谱系障碍（ASD）的扩展奠定基础。主要研究人员拥有独特的能力和资源，为开展这项创新工作提供了绝佳的机会。公共健康相关性：该项目将使用磁共振成像 (MRI) 来检查大脑连接性的测量，以调查阿斯伯格症的社会缺陷。结果将进一步了解这种情况的生物学后果，并可能有助于开发新的诊断或治疗技术。