Oxide Glass Fiber Optimized for Short Pulse IR Lasers

针对短脉冲红外激光器优化的氧化物玻璃光纤

• 批准号: 7125969
• 负责人: DANH C TRAN
• 金额: $ 34.78万
• 依托单位: INFRARED FIBER SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125969
• 关键词: biomaterial development /preparation; biomedical equipment development; biotechnology; clinical biomedical equipment; fiber optics; germanium; infrared radiation; laser therapy; lasers; oxides

DESCRIPTION (provided by applicant): There is a clinical need for optimized fiber transmission of short pulse mid-IR laser radiation for surgical applications. Large potential markets such as skin resurfacing, dentistry, and ophthalmology utilize the Er:YSGG (2.79 mu/m) and Er:YAG (2.94 mu/m) lasers for therapeutic procedures. These lasers are capable of efficiently and precisely ablating both hard and soft tissues while avoiding the peripheral thermal damage and necrosis observed at other wavelengths. During Phase I, we developed an improved germanium fiber for short pulse and high power delivery by removal of bubbles, striation, and particles from the glass and began the development of a biocompatible fiber. Fiber transmission and fiber damage thresholds were determined at both short (500-ns) and long (8-300 us) pulse lengths, and laser parameters were optimized for efficient soft tissue ablation. Hybrid fibers consisting of silica and sapphire tips attached to a trunk fiber were developed to prevent damage of the fiber during contact tissue ablation, and tested for high power laser transmission. Phase II work will consist of six specific aims: (1) Improvement of the power handling and yield of germanium fibers by reducing remaining glass defects and improved fiber tip polishing. (2) Development of high performance and reliable germanium fibers from compositions that are biocompatible and pass the MEM cytotoxicity and intracutaneous injection tests, and study methods of fiber sterilizaton, such as autoclave and EtO. (3) Development of specialized fiber probe tip designs consisting of hybrid germanium/silica fibers, end caps, micro-lenses, side-firing fibers, and sculpted fiber tips, for flexible delivery of radiation during custom surgical procedures involving contact and non-contact laser tissue ablation. (4) Improvement of the Erbium laser spatial and temporal beam profile to provide higher fiber damage thresholds at the input/output ends of the fiber. (5) Q-switched ErYSGG transmission through fibers and specialty tips with measurement of the tissue ablation rates and quantification of the peripheral thermal and mechanical side effects. (6) Ablation of hard cataracts and precise incision of other, soft ophthalmic tissues for potential clinical applications using fiber delivery of short-pulse Er:YAG energy.

描述（由申请人提供）： 临床需要优化用于外科手术应用的短脉冲中红外激光辐射的光纤传输。皮肤重修、牙科和眼科等巨大的潜在市场利用 Er:YSGG (2.79 mu/m) 和 Er:YAG (2.94 mu/m) 激光器进行治疗。这些激光器能够高效、精确地消融硬组织和软组织，同时避免在其他波长下观察到的外围热损伤和坏死。在第一阶段，我们通过去除玻璃中的气泡、条纹和颗粒，开发了一种改进的锗光纤，用于短脉冲和高功率传输，并开始开发生物相容性光纤。在短（500 ns）和长（8-300 us）脉冲长度下确定光纤传输和光纤损伤阈值，并优化激光参数以实现有效的软组织消融。开发了由连接到主干光纤的二氧化硅和蓝宝石尖端组成的混合光纤，以防止接触组织消融过程中光纤损坏，并进行了高功率激光传输测试。 第二阶段的工作将包括六个具体目标：（1）通过减少剩余的玻璃缺陷和改进光纤尖端抛光来提高锗光纤的功率处理能力和产量。 （2）利用具有生物相容性并通过MEM细胞毒性和皮内注射测试的组合物开发高性能、可靠的锗纤维，并研究纤维灭菌方法，如高压灭菌器和EtO。 (3) 开发由混合锗/二氧化硅纤维、端盖、微透镜、侧面发射纤维和雕刻光纤尖端组成的专用光纤探针尖端设计，用于在涉及接触和非接触的定制手术过程中灵活地传递辐射激光组织消融。 (4) 铒激光器空间和时间光束轮廓的改进，以在光纤的输入/输出端提供更高的光纤损伤阈值。 (5) 通过纤维和特殊尖端进行 Q 开关 ErYSGG 传输，测量组织消融率并量化外周热和机械副作用。 (6) 使用短脉冲 Er:YAG 能量的光纤传输来消融硬白内障并精确切割其他软眼组织，以实现潜在的临床应用。

项目成果

Side-firing germanium oxide optical fibers for use with erbium:YAG laser.

用于铒：YAG 激光器的侧射氧化锗光纤。

• 发表时间: 2006-07
• 影响因子: 2.7
• 作者: Ngo, Anthony K;Fried, Nathaniel M
• 通讯作者: Fried, Nathaniel M

Comparison of germanium oxide fibers with silica and sapphire fiber tips for transmission of erbium: YAG laser radiation.

用于传输铒：YAG 激光辐射的氧化锗光纤与二氧化硅和蓝宝石光纤尖端的比较。

• 发表时间: 2006-09
• 影响因子: 2.4
• 作者: Polletto, Travis J;Ngo, Anthony K;Tchapyjnikov, Alexei;Levin, Ken;Tran, Danh;Fried, Nathaniel M
• 通讯作者: Fried, Nathaniel M