Network for Translational Research: Optical Imaging

转化研究网络：光学成像

基本信息

批准号：
7289862
负责人：
WAFIK S. EL-DEIRY
金额：
$ 122.42万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-26 至 2009-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7289862
关键词：
Address Algorithms Animal Model Apoptosis Automobile Driving Biological Biological Models Blood flow Cancer Biology Cancer Patient Clinic Colonic Neoplasms Development Early Diagnosis Event Funding Future Goals Hypoglycemia Hypoxia Image Imaging Techniques Industry Invasive Knowledge Lymphatic Spread Malignant Neoplasms Metabolic Methods Mind Modeling Molecular Monitor Neoplasm Metastasis Outcome Pathway interactions Phase Philadelphia Polyps Reagent Research Research Personnel Screening procedure Therapeutic Therapeutic Agents Toxic effect Toxicity due to chemotherapy Translating Translational Research Tumor Angiogenesis Validation angiogenesis cancer therapy improved lymph nodes molecular imaging multidisciplinary new technology novel novel therapeutics optical imaging response small molecule small molecule libraries technology development tumor

项目摘要

DESCRIPTION (provided by applicant): The "Philadelphia Team" of NTROI investigators is asking fundamental questions with respect to cancer development, lymph node metastases, tumor angiogenesis, and understanding therapeutic response and toxicity of chemotherapy. The Team is developing molecular optical imaging techniques and probes to address these fundamental questions in animal models and is employing technology development, optimization of imaging and independent validation using a variety of imaging techniques including optical imaging. The assembled group of investigators is multidisciplinary and multi-institutional, and includes partners from Industry. The focus and motivating force of this Team are the biological questions driving the required molecular imaging techniques, and this represents a major strength of the consortium. The experimental plan is highly translational with specific goals in mind including early detection of colonic neoplasms, early detection of lymphatic spread, non-invasive imaging of angiogenesis and its correlates hypoxia, hypoglycemia and blood flow, and early detection of specific markers of therapeutic response and toxicity. Efforts are in place to develop imaging of metabolic correlates, to make comparisons with other non-invasive methods, and to develop non-invasive optical imaging methods and probes. There is an effort to develop novel therapeutics to treat polyps, to inhibit angiogenesis and to specifically increase tumor apoptosis using available reagents and compounds as well as through high-throughput chemical library screening using specific molecular imaging algorithms to facilitate the identification of novel and effective agents for cancer therapy. Efforts are in place to develop interactions with industry to bring new technologies or models to the consortium, and efforts are in place to identify and fund projects that are in a Developmental phase. The proposed research directions are likely to have significant impact on the national effort in translational research to develop better methods for early detection, to better predict therapeutic outcome, and to identify novel therapeutic agents and combinations for the treatment of cancer patients.

描述（由申请人提供）： NTROI研究人员的“费城团队”正在询问有关癌症发展，淋巴结转移，肿瘤血管生成以及了解化学疗法的治疗反应和毒性的基本问题。该团队正在开发分子光学成像技术和探针，以解决动物模型中的这些基本问题，并使用包括光学成像在内的各种成像技术进行技术开发，优化成像和独立验证。组装的研究人员是多学科和多机构的，其中包括来自行业的合作伙伴。该团队的重点和激励力是推动所需分子成像技术的生物学问题，这代表了财团的主要优势。实验计划是高度转化的，考虑到特定目标，包括早期检测结肠肿瘤，淋巴扩散的早期检测，非侵入性的血管生成成像及其相关性及其相关性缺氧，低血糖和血液流动以及早期对治疗反应和毒性特异性标记的检测。为发展代谢相关性的成像，与其他非侵入性方法进行比较以及开发非侵入性光学成像方法和探针的比较是适当的。有一种努力开发新的治疗疗法来治疗息肉，抑制血管生成并使用可用的试剂和化合物以及通过高通量化学库筛选使用特定的分子成像算法来促进癌症治疗的新颖和有效剂的鉴定。为发展与行业的互动以将新技术或模型带入财团而做出了努力，并为识别和资助正在发展阶段的项目做出了努力。拟议的研究方向可能会对国家转化研究的全国努力产生重大影响，以开发出更好的早期检测方法，更好地预测治疗结果，并确定新颖的治疗剂和为癌症患者治疗的组合。