Action Monitoring in depression: ERP and fMRI correlates

抑郁症的行动监测：ERP 和 fMRI 的相关性

• 批准号: 7392191
• 负责人: AVRAM J HOLMES
• 金额: $ 0.72万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-07-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7392191
• 关键词: Accounting; Address; Affective; Agitation; Amygdaloid structure; Anhedonia; Anterior; Awareness; Behavioral; Biological Neural Networks; Brain; Classification; Clinical; Clinical Treatment; Clinical assessments; Cognitive; Cognitive deficits; Conflict (Psychology); Coupled; Data; Depressed mood; Desire for food; Development; Diagnosis; Diagnostic; Dissociation; Event; Event-Related Potentials; Exhibits; Failure; Feedback; Feeling; Fellowship; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Guilt; Heterogeneity; Hospitalization; Impairment; Individual; Individual Differences; Intervention; Knowledge; Link; Literature; Localized; Magnetic Resonance Imaging; Major Depressive Disorder; Measures; Mental Depression; Methodology; Methods; Modification; Monitor; Motor; Nature; Neurons; Neurosciences; Participant; Patient Self-Report; Patients; Pattern; Performance; Pharmacological Treatment; Phenotype; Plan B; Population; Prefrontal Cortex; Process; Rate; Relative (related person); Research; Research Training; Sleep disturbances; Staging; Stimulus; Structure; System; Techniques; Testing; Thinking; Translational Research; Treatment Efficacy; Variant; Work; behavior measurement; cingulate cortex; cognitive function; depressive symptoms; disorder control; dysphoria; executive function; hemodynamics; improved; neuroimaging; psychologic; relating to nervous system; response; treatment planning

DESCRIPTION (provided by applicant): Patients meeting clinical criteria for major depressive disorder (MOD) can present with varied clinical symptomatology including, but not limited to dysphoria, anhedonia, feelings of guilt/worthlessness, sleep disturbance, abnormal appetite, motor slowing, loss of energy, restlessness, and agitation. This heterogeneity within the current psychiatric nosological classification system interferes with the research and clinical treatment of MOD. Translational research, utilizing behavioral, electrophysiological, hemodynamic, and self-report methodology, offers the possibility to examine the correlation between the cortical regions hypothesized to be critical for distinct cognitive processes and variations in depressive symptomatology. As this research progresses the knowledge gained can be applied towards the implementation of targeted pharmacological treatments incorporating information pertaining to the involved neural regions of individual patients, and/or the tailoring of psychological therapies to address a specific pattern of dysfunction. The eventual result of this translational research would be the drastic improvement of treatment efficacy. Recently, advances in neuroimaging techniques have uncovered reliable structural and functional cortical abnormalities in patients with MOD. Specifically, evidence suggests that depression is associated with executive dysfunction, particularly in situations requiring adaptive behavioral adjustments in response to negative feedback or perceived failure. These deficits can be particularly debilitating, and are often associated with decreased functioning and increased hospitalization rates. When this literature is combined with findings implicating certain neural networks as critical subcomponents of adaptive behavioral responses clear patterns emerge. The project described herein proposes two studies to examine the neural underpinnings of this specific aspect of depressive symptomatology. In each study participants will perform a Stroop task coupled with a feedback manipulation. During the study sessions event-related potentials (ERP; study 1) and functional magnetic resonance imaging (fMRI; study 2) data will be collected. This research will assess the temporal and spatial nature of the cortical processes associated with the commission of errors and the receipt of task-relevant feedback in patients with MOD and healthy control participants. Isolating specific components of MOD and the associated underlying neural networks will encourage the development of individually tailored therapies and pharmacological interventions with the eventual goal of improving diagnoses and treatment.

描述（由申请人提供）：符合重度抑郁症（MOD）临床标准的患者可能会出现各种临床症状学，包括但不限于吞咽困难，Anhedonia，内gui/毫无用处/无价值，睡眠障碍，异常的食欲，运动慢，运动速度慢，能量丧失，躁动，躁动和搅动。当前的精神病学分类系统中的这种异质性干扰了MOD的研究和临床治疗。转化研究，利用行为，电生理，血液动力学和自我报告方法学，提供了研究的可能性，可以检查假定的皮质区域之间的相关性，假设对抑郁症状的独特认知过程和变化至关重要。随着这项研究的进展，获得的知识可用于实施针对性的药理学治疗，该药理治疗纳入了与各个患者相关神经区域有关的信息，和/或对心理疗法的裁缝以解决特定的功能障碍模式。这项翻译研究的最终结果将是治疗功效的急剧提高。最近，神经影像技术的进步发现了MOD患者的可靠结构和功能性皮质异常。具体而言，证据表明抑郁症与执行功能障碍有关，特别是在需要适应性行为调整的情况下，响应负面反馈或感知失败。这些缺陷可能特别令人衰弱，并且通常与功能下降和住院率提高有关。当这些文献与发现某些神经网络作为适应性行为反应的关键亚组成部分的发现结合在一起时，会出现。本文描述的项目提出了两项​​研究，以检查抑郁症状学这一特定方面的神经基础。在每个研究中，参与者将执行一项Stroop任务，并进行反馈操作。在研究过程中，将收集与事件相关的电位（ERP；研究1）和功能磁共振成像（fMRI；研究2）数据。这项研究将评估与错误犯罪相关的皮质过程的时间和空间性质，并在MOD和健康对照参与者的患者中收到与任务相关的反馈。隔离MOD的特定组成部分和相关的基础神经网络将鼓励开发单独量身定制的疗法和药理干预措施，最终的目标是改善诊断和治疗。