Chronic Kidney Disease in the Pakistani Population

巴基斯坦人口的慢性肾病

• 批准号: 7494504
• 负责人: Tazeen Jafar
• 金额: $ 5.08万
• 依托单位: AGA KHAN UNIVERSITY (PAKISTAN)
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7494504
• 关键词: Accounting; Age; American; Asians; Bangladesh; Cardiovascular Diseases; Cessation of life; Chronic Disease; Chronic Kidney Failure; Clinical Trials; Collaborations; Country; Creatinine; Cross-Sectional Studies; Cystatins; Data; Databases; Demographic Factors; Detection; Development; Diabetes Mellitus; Diagnosis; Early Diagnosis; Epidemic; Epidemiology; Equation; Europe; European; Gender; Glomerular Filtration Rate; Health; Health Policy; Hypertension; India; Individual; Investigation; Journals; Kidney Failure; Laboratories; Measures; Medical; Medical center; Meta-Analysis; Methods; National Health and Nutrition Examination Survey; New England; North America; Outcome; Pakistan; Patients; Performance; Population; Prevalence; Prevention; Prevention program; Principal Investigator; Proteinuria; Public Health; Publications; Race; Renal function; Research Personnel; Risk Factors; Screening procedure; Serum; Surrogate Markers; Surveys; Universities; Validation; Variant; abstracting; aged; base; disorder risk; improved; mortality; nutrition; parent grant; prevent; programs; tool

Pakistan is a developing Indo Asian country facing an epidemic of chronic diseases including hypertension, diabetes, and chronic kidney disease (CKD). Adverse outcomes of CKD include kidney failure, cardiovascular disease (CVD) and death, which can be prevented or delayed, in part, by early diagnosis and treatment. Unfortunately, CKD is underdiagnosed and undertreated, in part, due to difficulty in detecting reduced kidney function. GFR is accepted as the best measure of kidney function, which can be estimated from serum creatinine, age, gender, and race using estimating equations. However, there are limitations of the existing equations and none have been validated in the Indo Asian population (India, Pakistan, Bangladesh, SriLanka), which accounts for about a fifth of the world's population. We propose a population-based cross sectional study on 500 Pakistani subjects aged 40 years or over. We will perform rigorous statistical analysis of standardized laboratory measures and socio-demographic data to develop and validate GFR estimation equations in this population. The specific aims of the proposal are: 1. To measure GFR in a Pakistani population and collect data on socio-demographic factors that might relate to variation in GFR across populations. 2. To evaluate existing GFR estimation equations in a Pakistani population 3. To develop and validate a new GFR equation specific to a Pakistani population, and compare its performance to existing equations with respect to bias, precision, accuracy. The parent grant to Tufts- New England Medical Center is for development and validation new and GFR estimation equations from large databases from North America and Europe. The proposed FIRCA to Aga Khan University would extend the results of these investigations to the Indo Asian population. The investigators have a track record of a very successful FIRCA collaboration leading to dissemination of results in leading medical journals and incorporation in health care policy in Pakistan. The best equation identified in the proposed study would serve as a valuable tool in CKD screening, and would aid the development of a national program for detection and prevention of CKD in Pakistan. The proposed project aims to develop a valid glomerular filtration rate estimation equation in the Pakistani population that would serve as a valuable tool in chronic kidney disease screening and prevention programs in Indo Asian populations.

巴基斯坦是印亚发展中国家，面临着 慢性病流行，包括高血压、糖尿病和慢性肾病（CKD）。 CKD 的不良后果包括肾衰竭、心血管疾病 (CVD) 和死亡， 通过早期诊断和治疗可以部分预防或延迟。不幸的是，CKD 是 诊断和治疗不足，部分原因是难以检测肾功能下降。肾小球滤过率是 被认为是肾功能的最佳衡量标准，可以根据血清肌酐、年龄、 使用估计方程来确定性别和种族。然而，现有方程存在局限性 并且尚未在印亚人群（印度、巴基斯坦、孟加拉国、斯里兰卡）中得到验证， 约占世界人口的五分之一。我们提出基于人群的交叉 对 500 名 40 岁或以上巴基斯坦受试者进行的分段研究。我们将进行严格的统计 分析标准化实验室测量和社会人口统计数据以开发和验证 该人群的 GFR 估计方程。该提案的具体目标是： 1. 测量 GFR 并收集可能与巴基斯坦人口变化相关的社会人口因素数据 不同人群的 GFR。 2. 评估巴基斯坦人口中现有的 GFR 估计方程 3. 开发并验证针对巴基斯坦人群的新 GFR 方程，并比较其 现有方程在偏差、精度、准确度方面的性能。家长向塔夫茨大学拨款- 新英格兰医学中心负责开发和验证新的 GFR 估计方程 来自北美和欧洲的大型数据库。拟议的阿卡汗大学 FIRCA 将把这些调查的结果扩展到印亚人口。调查人员有一个 FIRCA 合作非常成功，导致成果在领先领域传播 医学期刊并纳入巴基斯坦的医疗保健政策。中确定的最佳方程 拟议的研究将作为 CKD 筛查的一个有价值的工具，并有助于开发 巴基斯坦检测和预防 CKD 的国家计划。拟议项目旨在开发一个有效的 巴基斯坦人口的肾小球滤过率估计方程将作为有价值的 印裔人群慢性肾脏病筛查和预防计划的工具。