Lipid Transport-Connecting Fundamental Membrane Assembly To Human Disease

脂质运输将基本膜组装与人类疾病联系起来

• 批准号: 7540356
• 负责人: DENNIS R. VOELKER
• 金额: $ 1万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7540356
• 关键词: ATP phosphohydrolase; ATP-Binding Cassette Transporters; Address; Anabolism; Area; Biochemistry; Brain; Canada; Cells; Defect; Development; Discipline; Disease; Endotoxins; Eukaryota; Eukaryotic Cell; Eye; Genetic; Genomics; Growth and Development function; Hereditary Disease; Human; International; Intestines; Intrahepatic Cholestasis; Laboratories; Lipids; Liver diseases; Lung; Minority; Molecular; Mus; None or Not Applicable; Oral; Participant; Postdoctoral Fellow; Process; Production; Prokaryotic Cells; Protein Family; Proteins; Research; Role; Scientist; Senior Scientist; Students; Transport Process; Woman; Work; abstracting; cell growth; cellular pathology; human disease; lipid transport; membrane assembly; posters; programs; steroid hormone; symposium; ATP phosphohydrolase; ATP-Binding Cassette Transporters; Address; Anabolism; Area; Biochemistry; Brain; Canada; Cells; Defect; Development; Discipline; Disease; Endotoxins; Eukaryota; Eukaryotic Cell; Eye; Genetic; Genomics; Growth and Development function; Hereditary Disease; Human; International; Intestines; Intrahepatic Cholestasis; Laboratories; Lipids; Liver diseases; Lung; Minority; Molecular; Mus; None or Not Applicable; Oral; Participant; Postdoctoral Fellow; Process; Production; Prokaryotic Cells; Protein Family; Proteins; Research; Role; Scientist; Senior Scientist; Students; Transport Process; Woman; Work; abstracting; cell growth; cellular pathology; human disease; lipid transport; membrane assembly; posters; programs; steroid hormone; symposium

DESCRIPTION (provided by applicant): Abstract Summary: This application is for support of the first international meeting focused solely upon the topic of cellular lipid transport and its relationship to human genetic diseases. The meeting will provide a forum for the latest research in this discipline, which is now rapidly expanding as a consequence of advances in the biochemistry, genetics and genomics of lipid transport in multiple eukaryotes. The meeting will convene from Oct 29-Nov 2, 2008; in Canmore, AB, Canada. The participants in the meeting will be leading scientists whose focus is upon lipid transport processes within cells, and the relationship of these processes to cellular pathology and human diseases. In addition to invited speakers, attendees will include senior scientists with active research programs in the topic areas of the conference, and graduate students and postdoctoral fellows from these laboratories. Women and minority scientists are encouraged to participate in this meeting and 25% of the invited speakers are women. There will be ample opportunities for presentation of work by attendees who are not invited speakers, during poster sessions, and short oral presentations, which are mixed with invited speaker presentations. The objectives of the meeting are to publicize the latest advances in the topics of cellular lipid transport and critically discuss how disease processes result from molecular defects. The topics to be addressed include: 1) ABC transporters and their roles in eye, lung and liver disease in humans and mice, and the biosynthesis of endotoxins in prokaryotes; 2) P-type ATPases and their role in fundamental membrane assembly processes of eukaryotes, and the development of intrahepatic cholestasis in humans; 3) the importance of lipid recognition proteins in cell growth and development and production of steroid hormones; and 4) the role of Niemann Pick C family proteins in controlling lipid transport processes in the intestine and brain and their relationship to specific disease processes. 7. Project Narrative N/A

描述（由申请人提供）：摘要：此申请是为了支持第一次国际会议，专注于细胞脂质运输的主题及其与人类遗传疾病的关系。该会议将为该学科的最新研究提供一个论坛，由于多个真核生物中脂质运输的生物化学，遗传学和基因组学的进步，现在正在迅速扩展。会议将从2008年10月29日至29日召集；在加拿大的坎莫尔。会议的参与者将是主要的科学家，他们的重点是细胞内的脂质运输过程，以及这些过程与细胞病理和人类疾病的关系。除了被邀请的演讲者外，与会者还将在会议的主题领域中包括具有活跃研究计划的高级科学家，以及这些实验室的研究生和博士后研究员。鼓励妇女和少数族裔科学家参加这次会议，有25％的受邀演讲者是妇女。在海报会议和简短的口头演示期间，与会人员不被邀请演讲的与会者会有足够的机会，并与邀请的演讲者演讲混合在一起。会议的目标是宣传细胞脂质转运主题的最新进展，并批判性地讨论疾病过程是如何由分子缺损引起的。要解决的主题包括：1）ABC转运蛋白及其在人类和小鼠中的肺和肝病中的作用，以及原核生物中内毒素的生物合成； 2）P型ATPases及其在真核生物的基本膜组装过程中的作用，以及人类肝内胆汁淤积的发展； 3）脂质识别蛋白在细胞生长，开发和产生类固醇激素的重要性； 4）Niemann Pick C家族蛋白在控制肠道和大脑中的脂质转运过程及其与特定疾病过程的关系中的作用。 7。项目叙述不/a