Studies of Autoimmunity and Coronary Artery Disease

自身免疫和冠状动脉疾病的研究

• 批准号: 7015035
• 负责人: DARCY S MAJKA
• 金额: $ 14.5万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-15 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7015035
• 关键词: acute phase protein; autoantibody; autoimmune disorder; biomarker; cardiovascular disorder epidemiology; clinical research; coronary disorder; human data; human subject; human tissue; inflammation; interview

DESCRIPTION (provided by applicant): Connective tissue diseases (CTD) have been identified as risk factors for coronary artery disease (CAD). Patients with CTD such as rheumatoid arthritis and systemic lupus erythematosus have a high prevalence of CAD and are younger than expected at the onset of CAD. It has been proposed that the association between these CTD and CAD is related to inflammation. Furthermore, circulating autoantibodies have been identified in CAD and it has been hypothesized that CAD may have autoimmune features. Circulating autoantibodies exist prior to CTD development and the presence of such autoantibodies in asymptomatic individuals is a predictor of future clinical CTD. Although the association between CTD and CAD has been established, an association between pre-clinical circulating autoantibodies and early CAD has not yet been explored. The proposed study will test the primary hypothesis that individuals with pre-clinical CTD related autoimmunity are more likely to demonstrate subsequent development of sub-clinical CAD. To test this hypothesis, the following Specific Aims are proposed using an existing database: 1) Determine the association between autoimmunity measured in stored sera collected in 1992 and the subsequent development of sub-clinical CAD measured in 2000 and 2005. 2) Assess whether autoimmunity measured in 1992 predicts future increased levels of C-reactive protein (CRP) and whether the relationship between autoimmunity and CAD is mediated by CRP level. These aims will be accomplished by a team of investigators within the Division of Rheumatology and Department of Preventive Medicine at Northwestern University. The investigators will utilize a previously established study, the Coronary Artery Risk Development in Young Adults (CARDIA) study, a prospective cohort of 5108 subjects followed since 1985 for development of novel cardiac risk factors. With its extensive epidemiologic database and stored serum collected serially and available from 3500 individuals over the past 20 years, the CARDIA study is an ideal resource for this proposed study.

描述（由申请人提供）：结缔组织疾病（CTD）已被确定为冠状动脉疾病（CAD）的危险因素。 类风湿性关节炎、系统性红斑狼疮等 CTD 患者的 CAD 患病率较高，且 CAD 发病年龄比预期年轻。有人提出，这些 CTD 和 CAD 之间的关联与炎症有关。此外，已在 CAD 中鉴定出循环自身抗体，并推测 CAD 可能具有自身免疫特征。循环自身抗体在 CTD 发生之前就已存在，无症状个体中此类自身抗体的存在是未来临床 CTD 的预测因子。尽管 CTD 与 CAD 之间的关联已被确定，但临床前循环自身抗体与早期 CAD 之间的关联尚未被探索。拟议的研究将检验主要假设，即患有临床前 CTD 相关自身免疫的个体更有可能出现亚临床 CAD 的后续发展。为了检验这一假设，使用现有数据库提出了以下具体目标： 1) 确定 1992 年收集的储存血清中测量的自身免疫与 2000 年和 2005 年测量的亚临床 CAD 的后续发展之间的关联。 2) 评估是否存在自身免疫1992 年测量的结果可预测未来 C 反应蛋白 (CRP) 水平的增加以及自身免疫与 CAD 之间的关系是否由以下因素介导CRP 水平。这些目标将由西北大学风湿病科和预防医学系的一组研究人员来实现。研究人员将利用之前开展的一项研究，即年轻人冠状动脉风险发展 (CARDIA) 研究，该研究是自 1985 年以来对 5108 名受试者进行的前瞻性队列研究，旨在发现新的心脏危险因素。 CARDIA 研究拥有广泛的流行病学数据库和过去 20 年从 3500 名个体连续收集的储存血清，是这项拟议研究的理想资源。