Graded Structures for Damage Resistant All-Ceramic Restorations

用于抗损伤全瓷修复体的分级结构

• 批准号: 7472585
• 负责人: Yu Zhang
• 金额: $ 38.08万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7472585
• 关键词: Accounting; Aluminum Oxide; Behavior; Biomedical Engineering; Cementation; Ceramics; Cereals; Class; Classification; Clinical; Condition; Dental; Dental Porcelain; Dental Prosthesis; Dental crowns; Diet; Eating; Engineering; Environment; Equilibrium; Esthetics; Exhibits; Failure; Fatigue; Figs - dietary; Finite Element Analysis; Fracture; Generations; Glass; Goals; Growth; Health; Heating; Industry; Infiltration; Invasive; Investigation; Knowledge; Life; Life Style; Literature; Macor; Maps; Morbidity - disease rate; Optics; Orthopedics; Patients; Permeability; Play; Porosity; Property; Prosthesis; Public Health; Radial; Rate; Relative (related person); Reporting; Research; Research Personnel; Residual state; Resistance; Role; Science; Silicon Dioxide; Slide; Social Functioning; Staging; Steel; Stress; Structure; Surface; System; Technology; Temperature; Thick; Tooth structure; Water; Work; Zirconium; aluminosilicate; base; biomaterial compatibility; ceramic restoration; cost; design; improved; interest; layered ceramics; loss of function; next generation; programs; response; restorative dentistry; silicon nitride; theories; tungsten carbide (WC); yttria; zirconium oxide

DESCRIPTION (provided by applicant): Ceramics are widely used in dental and orthopedic prostheses because of their aesthetics, inertness, and biocompatibility. However, ceramics are vulnerable to fracture which accounts for millions of dollars annually in replacement costs and can cause significant patient discomfort and loss of productive lifestyle. Our preliminary investigations have established relations between failure modes and crown thickness, surface conditions, properties of the ceramic, and loading conditions. These findings indicate that monolithic glass- ceramic crowns and veneered alumina crowns are vulnerable to both near-contact occlusal damages and cementation internal surfaces radial fractures, while the veneered Y-TZP crowns are prone to veneer fracture owing to the superior strength of zirconia frameworks. These findings are consistent with clinical reports. It is the fracture problem of ceramic prostheses that motivated us to develop a new generation of damage resistant ceramic prostheses utilizing functionally graded materials. Recent theoretical and experimental advances demonstrate unprecedented resistance to contact damage in functionally graded materials that otherwise cannot be realized in conventional homogeneous materials. Our long-term goal is to develop an aesthetic, strong, thin zirconia based functionally graded material for less invasive all-ceramic posterior crowns and bridges, foreshadowing possibilities for orthopedic and other engineering applications. The objective of this proposal is to fabricate and validate the contact and flexural damage resistances of ceramic layer structures with continuous gradation from both top and bottom surfaces. We propose to achieve this objective through two specific aims: 1. Develop and characterize a new glass/zirconia/glass composite with continuous elastic modulus gradation from outer surfaces (low modulus glass-ceramic) to interior (strong, dense, fine-grain zirconia); and 2. Optimize the function-property (aesthetics, damage resistance-microstructure) relation of glass/zirconia/glass subjected to cyclic loading in water. Our preliminary studies have demonstrated that a functionally graded glass/zirconia/glass sandwich structure with improved damage resistance and aesthetics compared to their bulk zirconia counterparts can be produced by infiltrating a low elastic modulus glass-ceramic into the surfaces of a presintered zirconia. Relevance to public health: Knowledge generated from this investigation will guide design of a new generation of functionally graded ceramic dental and orthopedic prostheses with improved lifetime by resistance to contact damage and flexural fatigue, reducing morbidity and costs of replacement to the public.

描述（由申请人提供）：陶瓷因其美观、惰性和生物相容性而广泛用于牙科和骨科假体。然而，陶瓷很容易断裂，每年的更换成本高达数百万美元，并可能导致患者严重不适和生产力生活方式的丧失。我们的初步研究已经建立了失效模式与冠厚度、表面条件、陶瓷性能和负载条件之间的关系。这些发现表明，整体玻璃陶瓷冠和贴面氧化铝冠容易受到近接触咬合损伤和粘接内表面径向断裂的影响，而贴面Y-TZP冠由于氧化锆框架的优越强度而容易发生贴面断裂。这些发现与临床报告一致。正是陶瓷假体的断裂问题促使我们利用功能梯度材料开发新一代抗损伤陶瓷假体。最近的理论和实验进展表明，功​​能梯度材料具有前所未有的抗接触损伤能力，而这在传统均质材料中是无法实现的。我们的长期目标是开发一种美观、坚固、薄的氧化锆基功能梯度材料，用于微创全瓷后牙冠和牙桥，为骨科和其他工程应用奠定了基础。该提案的目的是制造并验证从顶面和底面连续渐变的陶瓷层结构的接触和弯曲损伤抵抗能力。我们建议通过两个具体目标来实现这一目标： 1. 开发并表征一种新型玻璃/氧化锆/玻璃复合材料，其从外表面（低模量玻璃陶瓷）到内部（坚固、致密、细晶氧化锆）具有连续的弹性模量梯度）； 2.优化玻璃/氧化锆/玻璃在水中循环载荷作用下的功能-性能（美观、抗损伤-微观结构）关系。我们的初步研究表明，通过将低弹性模量玻璃陶瓷渗透到预烧结氧化锆的表面，可以生产出功能梯度玻璃/氧化锆/玻璃夹层结构，与块状氧化锆同类产品相比，该结构具有更高的耐损伤性和美观性。与公共卫生的相关性：本次调查产生的知识将指导新一代功能分级陶瓷牙科和骨科假体的设计，这些假体通过抵抗接触损伤和弯曲疲劳来提高使用寿命，从而降低公众的发病率和更换成本。