Obesity development and CVD risk factor--Filipino women

肥胖发展和心血管疾病危险因素——菲律宾女性

• 批准号: 7127907
• 负责人: Linda S Adair
• 金额: $ 67.63万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127907
• 关键词: Filipino; aging; behavioral /social science research tag; beverages; biomarker; blood pressure; body composition; body physical activity; cardiovascular disorder epidemiology; cardiovascular disorder risk; clinical research; dietary lipid; generation difference; human data; human tissue; lifestyle; longitudinal human study; metabolic syndrome; nutrition related tag; obesity; questionnaires

DESCRIPTION (provided by applicant): The proposed research aims to identify determinants of weight gain and development of cardiovascular disease risk factors in an Asian population undergoing the nutrition transition. The research is based on the Cebu Longitudinal Health and Nutrition Survey (CLHNS), conducted in the second largest metro area of the Philippines. This community-based survey recruited pregnant women in 1983-84, and we have studied the women and their index child for the past two decades. Taking a life course perspective, we use the two- generation sample to examine childhood antecedents of risk factors in young adults and early adult antecedents of later adult levels of CVD risk factors. We focus on heterogeneity in how risk factors cluster within and between generations as a means to identify etiology. The CLHNS collected detailed longitudinal community, household, and individual level data in all survey years, allowing us to develop causal models. Blood pressure was measured in the 1998-2005 surveys. Fasting blood samples collected in a subset of youth in 1998, and in all youth and their mothers in 2005 provide a wide range of biomarkers related to chronic disease. We will model the determinants of weight, adiposity, and waist circumference from childhood young adulthood in the birth cohort, and in their adult mothers over a 20 year time period. We focus on the effects of large changes in diet (e.g. increased fat and soft drink consumption) and physical activity (e.g. increased sedentary occupational and leisure activity) that have accompanied rapid socioeconomic changes and modernization in Cebu. We will then determine the prevalence and patterns of co-occurrence of risk factors that comprise the metabolic syndrome (atherogenic lipid profiles, elevated fasting blood glucose, insulin resistance, raised blood pressure) and other CVD risk factors (homocysteine, CRP, and adiponectin) in adult women and their young adult offspring, identifying similarities and differences in how risk factors cluster in the 2 generations. Finally, we will model determinants of CVD risk factor clustering in mothers and offspring, focusing on prior weight and adiposity trajectories, and prior and current diet composition and physical activity, and for adult women, the relationship of occurrence of risk factors to physical functioning.

描述（由申请人提供）：拟议的研究旨在确定正在经历营养转型的亚洲人群体重增加和心血管疾病危险因素发展的决定因素。该研究基于在菲律宾第二大都市区进行的宿雾纵向健康和营养调查（CLHNS）。这项以社区为基础的调查在 1983-84 年招募了孕妇，我们在过去二十年里对这些妇女及其指标孩子进行了研究。从生命历程的角度来看，我们使用两代样本来检查年轻人中危险因素的童年前因和成年后CVD危险因素水平的早期前因。我们关注风险因素在代内和代际之间如何聚集的异质性，作为识别病因的一种手段。 CLHNS 在所有调查年份收集了详细的纵向社区、家庭和个人层面的数据，使我们能够开发因果模型。 1998-2005 年的调查测量了血压。 1998 年收集的一部分青少年以及 2005 年收集的所有青少年及其母亲的空腹血液样本提供了与慢性病相关的广泛生物标志物。我们将对出生队列及其成年母亲从童年到成年的体重、肥胖和腰围的决定因素进行建模，时间跨度超过 20 年。我们重点关注饮食（例如脂肪和软饮料消耗量的增加）和体力活动（例如久坐的职业和休闲活动的增加）的巨大变化所产生的影响，这些变化伴随着宿雾社会经济的快速变化和现代化。然后，我们将确定包括代谢综合征（致动脉粥样化血脂、空腹血糖升高、胰岛素抵抗、血压升高）和其他 CVD 风险因素（同型半胱氨酸、CRP 和脂联素）在内的风险因素的患病率和共现模式。在成年女性及其年轻成年后代中，确定两代人中危险因素聚集方式的相似点和差异。最后，我们将对母亲和后代中 CVD 危险因素聚集的决定因素进行建模，重点关注先前的体重和肥胖轨迹、先前和当前的饮食构成和体力活动，以及对于成年女性，危险因素的发生与身体机能的关系。