Net Lifetime Health Effects of Alcohol Use & Abuse

饮酒对终生健康的净影响

• 批准号: 7058860
• 负责人: R. Curtis Ellison
• 金额: $ 70.83万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-16 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7058860
• 关键词: accidents; adult human (21+); age difference; alcoholic beverage consumption; alcoholism /alcohol abuse; alcoholism /alcohol abuse information system; bone fracture; cardiovascular disorder epidemiology; caucasian American; clinical research; cognition; disease /disorder proneness /risk; epidemiology; epilepsy; functional ability; human data; human mortality; liver disorder; longitudinal human study; mental health epidemiology; neoplasm /cancer; stroke; syncope; technology /technique development

DESCRIPTION (provided by applicant): While the association of alcohol consumption and the risk of many specific disease entities has been investigated in great detail, there are serious deficiencies in knowing the overall relation of alcohol consumption to health and disease throughout the adult lifespan. Given that alcohol has both detrimental and possibly beneficial effects, it is important to know its net effects on the risk of death and of a number of diseases and health conditions that may relate, either positively or inversely, to its use or abuse. We propose to use data collected over 27-55 years among the 10,000+ subjects in the population-based Framingham Study to relate the amount and pattern of alcohol consumption over a large part of their adult lifetime to two of the most important aspects of life: (a) survival (total mortality) and (b) indices of cognitive function. We will also relate alcohol consumption to indices of disability and to a number of other diseases and conditions affected by alcohol intake, including liver disease, accidents, specific cancers, hypertension, coronary disease, stroke, other cardiovascular diseases, seizures, syncope, falls and fractures. The Framingham Study is unique in being able to provide repeated measurements of the amount and pattern of alcohol use and measures of health and disease over what is essentially the entire adult lifespan (until old age for most and until death for more than one half of subjects). The proposed study would carry out an extensive review of health information collected at every encounter with each subject throughout follow up, classify each subject at each encounter according to alcohol consumption (amount and pattern of drinking), identify those with alcohol use disorders, prepare a complete dataset of diseases and causes of death (currently complete only for cardiovascular disease and cancer), and then examine the relation of alcohol use and alcohol use disorders to total mortality (overall and by age strata) and to indices of cognitive function assessed repeatedly over time. The net effects of varying amounts and patterns of drinking would be related to outcomes at different ages. The study will produce a unique dataset and will provide information that should improve our knowledge of the net effects of alcohol throughout adult life.

描述（由申请人提供）：虽然已经对饮酒与许多特定疾病风险之间的关联进行了详细调查，但在了解成人一生中饮酒与健康和疾病的总体关系方面存在严重缺陷。鉴于酒精既具有有害作用，也可能具有有益作用，因此了解其对死亡风险以及许多疾病和健康状况的净影响非常重要，这些风险可能与其使用或滥用呈正向或反向关系。我们建议使用弗雷明汉研究中超过 10,000 名受试者在 27-55 年间收集的数据，将他们成年后大部分时间的饮酒量和模式与生活中两个最重要的方面联系起来： (a) 生存率（总死亡率）和 (b) 认知功能指数。我们还将饮酒与残疾指数以及受酒精摄入影响的许多其他疾病和病症联系起来，包括肝病、事故、特定癌症、高血压、冠心病、中风、其他心血管疾病、癫痫、晕厥、跌倒和骨折。弗雷明汉研究的独特之处在于能够重复测量酒精使用量和模式，以及在基本上整个成年人生命周期（大多数受试者直到老年，超过一半受试者直到死亡）的健康和疾病测量）。拟议的研究将对在整个随访过程中与每个受试者每次接触时收集的健康信息进行广泛审查，根据饮酒量（饮酒量和模式）对每次接触时的每个受试者进行分类，识别那些患有酒精使用障碍的人，准备一份完整的疾病和死亡原因数据集（目前仅针对心血管疾病和癌症），然后检查饮酒和酒精使用障碍与总死亡率（总体死亡率和按年龄层）以及与反复评估的认知功能指数的关系时间。不同饮酒量和饮酒方式的净效应与不同年龄的结果有关。该研究将产生一个独特的数据集，并将提供有助于提高我们对酒精在整个成年生活中的净影响的了解的信息。