MODELING OF VIRAL PACKAGING MOTORS

病毒包装电机的建模

• 批准号: 7358872
• 负责人: CHARLES L BROOKS
• 金额: $ 2.21万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358872
• 关键词: MODELING; VIRAL; PACKAGING; MOTORS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Many viruses use molecular motors to package the nucleic acid into capsids. The viral packaging motor is a highly robust and efficient molecular machinery driven by the adenosine triphosphate (ATP) hydrolysis. The high-resolution structure of the packaging motor was solved for the bacteriophage ?29 and ?22 by means of X-ray crystallography and cryo-electron microscopy. Due to the complexity of its structure, however, the dynamic behavior of the packaging motor still remains elusive. Understanding the dynamic mechanism of the packaging motor is essential to provide new insights into the principles of molecular machinery. In this study, we will investigate the DNA dynamics in the packaging motor using coarse-grained and detailed atomistic simulations.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。许多病毒使用分子马达将核酸包装到衣壳中。病毒包装马达是一种由三磷酸腺苷（ATP）水解驱动的高度稳健且高效的分子机器。通过 X 射线晶体学和冷冻电子显微镜解析了噬菌体 ?29 和 ?22 的包装电机的高分辨率结构。然而，由于其结构的复杂性，包装电机的动态行为仍然难以捉摸。了解包装电机的动态机制对于提供对分子机械原理的新见解至关重要。在这项研究中，我们将使用粗粒度和详细的原子模拟来研究包装电机中的 DNA 动力学。