Industrial Pollutants and Risk of Non-Hodgkins Lymphoma

工业污染物和非霍奇金淋巴瘤的风险

• 批准号: 7127666
• 负责人: ANNECLAIRE J DE ROOS
• 金额: $ 8.45万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127666
• 关键词: cancer risk; carbopolycyclic compound; clinical research; dioxins; environment related neoplasm /cancer; environmental exposure; furans; human subject; industrial waste; industry; interview; nonHodgkin' s lymphoma; solvents

DESCRIPTION (provided by applicant): Industrial pollution has been suspected as a cause of non-Hodgkin lymphoma (NHL) particularly because the rates of this cancer increased dramatically during the latter half of the 20th century, lagging slightly behind a period of expanded industrial production in the United States. Despite a compelling hypothesis, there have been few rigorous studies which examined the association between NHL and specific industrial pollutants. Such studies are becoming more readily implemented with the increasing availability and ease-of-use of desktop geographic information systems (GIS) and public databases of industry location and emissions. The investigators propose a case-control study of long-term environmental exposure to industrial pollutants and risk of NHL. Subjects for the proposed study are cases (n=855) and controls (n=781) from an existing NCI-sponsored multi-site study, recruited from Los Angeles County and the Seattle and Detroit metropolitan regions. Residential histories will be used to characterize the location of subjects during the 30-year time period of etiologic interest. A geodatabase will be created for exposure assessment purposes, to contain information on industries including location, operation type, and emissions, as recorded in various sources including the Environmental Protection Agency's Toxics Release Inventory (TRI) and historical business directories from California, Washington, and Michigan States. We will examine NHL risk in relation to specific types of industry, including petroleum refining and pulp and paper mills. The risk associated with specific industrial pollutants of interest, including solvents, polycyclic aromatic hydrocarbons, and dioxins, will be examined after developing exposure contours based on emissions quantities and meterologic data. The study's wealth of existing data on long-term residential history and potential confounders, in addition to the use of GIS for development of detailed exposure metrics, will enable the investigators to make a useful contribution to the current state of knowledge regarding environmental causes of NHL.

描述（由申请人提供）：工业污染被怀疑是非霍奇金淋巴瘤 (NHL) 的一个原因，特别是因为这种癌症的发病率在 20 世纪下半叶急剧增加，略落后于工业生产扩大的时期在美国。尽管有令人信服的假设，但很少有严格的研究来检验 NHL 与特定工业污染物之间的关联。随着桌面地理信息系统（GIS）以及工业位置和排放公共数据库的可用性和易用性不断提高，此类研究变得更加容易实施。研究人员提议对长期环境暴露于工业污染物和 NHL 风险进行病例对照研究。拟议研究的受试者是来自 NCI 资助的现有多中心研究的病例 (n=855) 和对照 (n=781)，从洛杉矶县、西雅图和底特律大都市区招募。居住史将用于描述受试者在 30 年病因学兴趣期间的位置。将创建一个用于暴露评估目的的地理数据库，其中包含有关行业的信息，包括位置、运营类型和排放量，这些信息记录在各种来源中，包括环境保护局的有毒物质排放清单 (TRI) 以及来自加利福尼亚州、华盛顿州和美国的历史企业名录。密歇根州。我们将研究与特定类型行业相关的 NHL 风险，包括石油精炼以及纸浆和造纸厂。在根据排放量和气象数据制定暴露轮廓后，将检查与特定感兴趣的工业污染物（包括溶剂、多环芳烃和二恶英）相关的风险。该研究除了使用 GIS 来制定详细的暴露指标外，还拥有大量有关长期居住史和潜在混杂因素的现有数据，将使研究人员能够对 NHL 环境原因的当前知识状况做出有益的贡献。