FIELD APPLICABLE SEROLOGIC DIAGNOSIS TESTS: CYSTICEROSIS & TAENIASIS

现场适用的血清学诊断测试：囊虫病

• 批准号: 6201203
• 负责人: ROBERT H GILMAN
• 金额: $ 8.81万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6201203
• 关键词: Cestoda; Peru; communicable disease control; cooperative study; diagnosis design /evaluation; disease carrier state; disease reservoirs; enzyme linked immunosorbent assay; epidemiology; feces analysis; field study; helminthiasis; human subject; parasitic disease diagnosis; serology /serodiagnosis; swine; western blottings

Human neurocysticercosis affects millions of people in Latin America, Africa, and Asia, and is also present in developing countries with high immigration rates. This zoonotic disease is the major cause of acquired epilepsy in most of the world, and raises two- to four-fold the rates of epilepsy in endemic zones. Improvement of serological and imagenological diagnostic techniques, including the introduction by our group of the EITB-C (enzyme-linked immunoelectrotransfer blot assay) led to important advances in epidemiology and clinical management of Cysticerosis in the last ten years. The central theme of this project to complete development and improve the performance of he EITB-C and EITB-T, tests for Cysticerosis and taeniasis, respectively. These tests and their field versions will provide a set of critical and practical tools for patient identification, location, and management. When coupled with GPS data, these data should help us to better understand the transmission dynamics of Cysticerosis. Finally, when use in sentinal pigs, the EITB-C and its field version will allow us to accurately measure the efficacy of control projects.

人类神经囊性会影响拉丁美洲，非洲和亚洲的数百万人，并且在移民率高的发展中国家也存在。这种人畜共患病是世界上大部分地区获得癫痫病的主要原因，并且在地方性区域中提高了癫痫发作率的二到四倍。血清学和成像学诊断技术的改进，包括我们小组的EITB-C（酶联免疫转移传递印迹分析）的引入，导致了过去十年来流行病学和囊性疾病的临床管理的重要进展。该项目的核心主题是完成开发并改善HE EITB-C和EITB-T的性能，分别测试囊肿和taeniasis。这些测试及其现场版本将为患者识别，位置和管理提供一组关键和实用的工具。当与GPS数据结合使用时，这些数据应帮助我们更好地了解囊肿的传播动力学。最后，当在Sentinal Pigs中使用时，EITB-C及其现场版本将使我们能够准确测量控制项目的功效。