Thin Film Magnetic Sensors for Ultrathin Bronchoscope Navigation

用于超薄支气管镜导航的薄膜磁传感器

• 批准号: 7052227
• 负责人: Erik Lange
• 金额: $ 12.71万
• 依托单位: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-25 至 2007-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7052227
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; biopsy; biosensor device; bronchoscopy; diagnosis design /evaluation; diagnostic tests; lung imaging /visualization /scanning; lung neoplasms; magnetic field; mathematics; monitoring device

DESCRIPTION (provided by applicant): Koronis Biomedical Technology Corporation (KBT) proposes to develop a giant magneto-resistive (GMR) sensor for use in ultrathin bronchoscope navigation systems. Bronchoscopy is used to locate anomalies in a patient's bronchus and if necessary, take a biopsy. Unfortunately, the majority of target lung lesions are located in the peripheral areas of the lungs where large bronchoscopes cannot reach. Approximately 2/3rds of diagnostic bronchoscopy procedures in the lung's periphery fail and must be repeated or replaced with more invasive approaches such as fluoroscopic guided percutaneous needle biopsy or surgical biopsy. New ultrathin bronchoscopes provide physicians a tool capable of moving further into the reaches of the lung periphery. Ultrathin bronchoscopes are smaller than 3 mm in diameter, about half the size of a standard instrument. Commercial systems for bronchoscope navigation have been introduced that rely upon miniature magnetic field pick-up coils rigidly located within the bronchoscope to sense external reference magnetic fields. The wire-wound pick-up coils have substantial drawbacks including size, cost, and performance. They are generally too large for use in ultrathin bronchoscopes and are unsuitable for further miniaturization. The proposed program uses solid-state thin-film giant magneto-resistive (GMR) magnetic field sensors to reduce the size, increase the performance, and decrease the cost of bronchoscope navigation systems. The aims of the phase I program seek to demonstrate that a GMR sensor can be designed suitable for application in an ultrathin bronchoscope. The phase I program will design and prototype a GMR sensor which is small enough in size to be used in an ultrathin bronchoscope. The phase II program will manufacture the GMR sensor, and insert and evaluate it in a prototype bronchoscope navigation system.

描述（由申请人提供）：Koronis Biomedical Technology Corporation（KBT）提议开发一种用于超薄支气管镜导航系统的巨磁阻（GMR）传感器。支气管镜检查用于定位患者支气管的异常情况，并在必要时进行活检。不幸的是，大多数目标肺部病变位于大型支气管镜无法到达的肺部周边区域。大约 2/3 的肺周围诊断性支气管镜检查程序失败，必须重复或用更具侵入性的方法代替，例如荧光镜引导的经皮穿刺活检或手术活检。新型超薄支气管镜为医生提供了一种能够进一步移动到肺周边的工具。超薄支气管镜的直径小于 3 毫米，约为标准仪器尺寸的一半。已经引入了用于支气管镜导航的商业系统，该系统依靠刚性地位于支气管镜内的微型磁场拾取线圈来感测外部参考磁场。绕线拾波线圈具有很大的缺点，包括尺寸、成本和性能。它们通常对于超薄支气管镜来说太大，并且不适合进一步小型化。该计划使用固态薄膜巨磁阻（GMR）磁场传感器来减小支气管镜导航系统的尺寸、提高性能并降低成本。第一阶段计划的目标是证明 GMR 传感器可以设计成适合超薄支气管镜中的应用。第一阶段项目将设计并制作 GMR 传感器原型，该传感器尺寸足够小，可用于超薄支气管镜。第二阶段计划将制造 GMR 传感器，并将其插入原型支气管镜导航系统中并进行评估。