Hazardous Air Pollutants and Lymphohematopoietic Cancer Incidence in Houston 1995

1995 年休斯顿有害空气污染物和淋巴造血系统癌症发病率

基本信息

批准号：
7500249
负责人：
ELAINE SYMANSKI
金额：
$ 7.43万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-24 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7500249
关键词：
1,3-Butadiene Accounting Address Advisory Committees Air Air Pollutants Air Pollution Ally Animal Model Area Benzene Carcinogens Censuses Chemicals Chronic Cities Coal Communities County Data Data Set Data Sources Disease Disease regression Equation Ethnic Origin Exposure to Future Geographic Information Systems Grant Health Housing Incidence Investigation Link Literature Location Malignant Neoplasms Maps Methods Metric Modeling Monitor Multiple Myeloma Numbers Occupational Occupations Outcome Petroleum Plants Play Public Health Public Health Schools Purpose Race Rate Reporting Research Research Design Risk Risk Assessment Role Score Site Smoking Source Spatial Distribution Testing Texas Time Title Workplace abstracting air monitoring base cancer epidemiology cancer risk cost density innovation interest manufacturing facility metropolitan neoplasm registry pollutant programs

项目摘要

DESCRIPTION (provided by applicant): Resubmission PAR-06-294 Small Grants Program for Cancer Epidemiology PI: Symanski, Elaine 1 R03 CA128106-01 Title: Hazardous Air Pollutants and Lymphohematopoietic Cancer Incidence in Houston 1995-2005 Research and Related attachment #6: Project Summary/Abstract Page Hazardous Air Pollutants and Lymphohematopoietic Cancer Incidence in Houston, 1995-2005 Harris County, Texas (Houston) has a large presence of industrial facilities, documented poor air quality and significantly higher cancer rates than the remainder of Texas. Given citizen concerns in this 4th largest city, Mayor Bill White recently partnered with UT School of Public Health to conduct a risk assessment associated with ambient levels of hazardous air pollutants (HAPs). This report identified definite risks associated with ambient concentrations of specific pollutants and strongly encouraged future analytic studies linking these pollutants with health outcomes. This project addresses a gap in the literature by evaluating an association between lymphohematapoietic cancer (hereafter LH cancer) incidence and air pollution in the Houston metropolitan area, with particular emphasis on three compounds - benzene, 1,3-butadiene and styrene. These compounds were selected as all are known carcinogens in animal models and have been linked with LH cancer in occupational studies. Analyses are planned of existing data sets obtained from the Texas Cancer Registry (TCR) from 1995-2005 and the Texas Commission on Environmental Quality (TCEQ) from 1992-2003. Data will be analyzed at the census tract level. Specific Aims are: (1) To investigate the spatial and temporal distribution (clustering) of LH cancer incidence in Harris and surrounding counties, (2) To evaluate the association between distance from industrial sources and LH cancer incidence, (3) To identify optimal methods for assessing ambient levels of benzene, 1,3-butadiene and styrene using existing TCEQ monitoring data; and (4) To evaluate the association between ambient levels of benzene, styrene and 1,3-butadiene and LH cancer incidence using Poisson regression in single and multi-pollutant models, controlling for occupation, smoking, housing stability, race/ethnicity and other potential confounders. This study will incorporate methods for spatial interpolation (kriging) because the TCEQ monitoring sites are not distributed equally across the entire study area. This will be the first study to examine this association in Harris and seven surrounding counties (Texas) and is among the first to utilize monitored levels of HAPs to assess increased risks of LH cancer associated with air pollution, evaluating several analytic methods to determine the most appropriate approach to test this association. Resubmission PAR-06-294 Small Grants Program for Cancer Epidemiology PI: Symanski, Elaine 1 R03 CA128106-01 Title: Hazardous Air Pollutants and Lymphohematopoietic Cancer Incidence in Houston 1995-2005 Research and Related Information attachment #7: Project Narrative Page Project Narrative: The proposed research has direct relevance to public health by identifying census tracts in Harris and surrounding counties, Texas with greater than expected rates of lymphohematopoietic cancer. Additionally, this study will correlate these cancer rates with proximity to industrial facilities as well as ambient levels of three hazardous air pollutants of interest-benzene, styrene and 1,3-butadiene. This study will address a gap in the literature by examining the association between hazardous air pollutants (HAP) and cancer incidence in Harris County, Texas and will further explore innovative methods to evaluate this association utilizing existing data sources.

说明（由申请人提供）：重新提交 PAR-06-294 癌症流行病学小额赠款计划 PI：Symanski, Elaine 1 R03 CA128106-01 标题：1995-2005 年休斯顿有害空气污染物和淋巴造血癌症发病率研究及相关附件 #6：项目摘要/摘要页有害空气污染物和休斯顿淋巴造血癌症发病率，1995-2005 年德克萨斯州哈里斯县（休斯顿）拥有大量工业设施，空气质量较差，癌症发病率明显高于德克萨斯州其他地区。鉴于这座第四大城市的公民担忧，比尔·怀特市长最近与德州大学公共卫生学院合作，进行了与环境有害空气污染物 (HAP) 水平相关的风险评估。该报告确定了与特定污染物的环境浓度相关的明确风险，并强烈鼓励未来将这些污染物与健康结果联系起来的分析研究。该项目通过评估休斯顿都市区淋巴造血癌（以下简称 LH 癌）发病率与空气污染之间的关联，特别强调三种化合物——苯、1,3-丁二烯和苯乙烯，填补了文献中的空白。选择这些化合物是因为在动物模型中都是已知的致癌物，并且在职业研究中与 LH 癌症有关。计划对从 1995-2005 年得克萨斯州癌症登记处 (TCR) 和 1992-2003 年得克萨斯州环境质量委员会 (TCEQ) 获得的现有数据集进行分析。数据将在人口普查区层面进行分析。具体目标是：(1) 调查哈里斯及周边县 LH 癌症发病率的时空分布（聚类），(2) 评估距工业来源的距离与 LH 癌症发病率之间的关联，(3) 确定最佳使用现有 TCEQ 监测数据评估苯、1,3-丁二烯和苯乙烯环境水平的方法； (4) 在单一和多污染物模型中使用泊松回归评估苯、苯乙烯和 1,3-丁二烯的环境水平与 LH 癌症发病率之间的关联，并控制职业、吸烟、住房稳定性、种族/民族和其他因素潜在的混杂因素。本研究将采用空间插值法（克里金法），因为 TCEQ 监测点在整个研究区域的分布并不均匀。这将是第一个在哈里斯和七个周边县（德克萨斯州）检验这种关联的研究，也是第一个利用监测的 HAP 水平来评估与空气污染相关的 LH 癌症风险增加的研究之一，评估了几种分析方法以确定最重要的测试这种关联的适当方法。重新提交 PAR-06-294 癌症流行病学小额赠款计划 PI：Symanski, Elaine 1 R03 CA128106-01 标题：1995-2005 年休斯顿危险空气污染物和淋巴造血癌症发病率研究和相关信息附件 #7：项目叙述页面项目叙述：拟议的研究通过确定人口普查区域与公共卫生直接相关德克萨斯州哈里斯及周边县的淋巴造血系统癌症发病率高于预期。此外，这项研究还将这些癌症发病率与工业设施的接近程度以及三种有害空气污染物（苯、苯乙烯和 1,3-丁二烯）的环境水平联系起来。本研究将通过研究德克萨斯州哈里斯县有害空气污染物 (HAP) 与癌症发病率之间的关联来填补文献中的空白，并将进一步探索利用现有数据源评估这种关联的创新方法。