COBRE: UNM: FREE RADICALS IN ISCHEMIA: STROKE, BRAIN, GENE, MS PROTEASE

COBRE：UNM：缺血中的自由基：中风、大脑、基因、MS 蛋白酶

• 批准号: 7381210
• 负责人: Ke Jian Liu
• 金额: $ 24.13万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381210
• 关键词: brain; endopeptidases; free radicals; genes; ischemia; lead; stroke; tissues

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Stroke is the third leading cause of death and the leading cause of disability in the developed countries with ischemia accounting for approximately 80% of all strokes. Acute ischemic stroke results in heterogeneous changes in cerebral blood flow and brain metabolism in the affected region. Reduced tissue oxygenation and increased production of free radicals and proteases form a final pathway for cell death. The long term goal of our research is to understand the mechanism of free radical and proteases-mediated tissue injury, and design better pharmacological intervention strategies for stroke treatment.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。中风是发达国家的第三大死亡原因，是缺血的发达国家的主要原因，约占所有中风的80％。急性缺血性中风会导致受影响区域的脑血流和脑代谢的异质变化。减少组织氧合和增加的自由基和蛋白酶的产生形成了细胞死亡的最终途径。我们研究的长期目标是了解自由基和蛋白酶介导的组织损伤的机制，并为中风治疗设计更好的药理干预策略。