FUNCTIONAL BRAIN IMAGING IN NORMAL AGING

正常衰老过程中的功能性脑成像

• 批准号: 7378277
• 负责人: RODOLFO R LLINAS
• 金额: $ 2.06万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378277
• 关键词: FUNCTIONAL; BRAIN; IMAGING; NORMAL; AGING

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study hypothesizes the following: 1) Changes in dynamic neuronal network properties occur in the aging brain that affect sensory and cognitive processing and 2) these changes can be quantified by Magnetoencephalography (MEG). In general, although sensory processing occurs in dedicated units of the brain, the cognitive binding process, altered in a time-dependent manner by the aging process, will result in modifications of sensory-motor integration. The aims are the following: 1) To image and analyze the temporal reset of the auditory-evoked thalamo-cortical brain activity. 2) To investigate whether correlations exist between psychophysical somatosensory thresholds and specific patterns of neural activity in the primary sensory cortex in normal and aging individuals. 3) To image and analyze the temporal reset of visual-evoked thalamo-cortical brain activity. 4) To analyze language perception processing and its changes during aging. 165 individuals (in groups of 15 per 5-year age categories from 25-80) will be recruited and subjected to neuropsychological testing and spontaneous and sensory-evoked MEG measurements to detect reset and binding parameters from stimuli relating to the 4 aims. MEG findings will be overlaid on MRI/MRS images to reveal underlying neurobiologic correlates of sensory and cognitive decline in normal aging. In addition, metric and spectral parameters will be used to define similarity scores between subjects, as well as individual scores. The individual scores can be correlated with neuropsychologic assessments. The clinical and cognitive assessments will be repeated at 2-year intervals. Patient recruitment will include an existing population of patients followed by the NIA-supported Alzheimer's Disease Center at NYU. The Dept. of Psychiatry will also provide well-characterized, healthy, cognitively normal subjects. This is a bold attempt to characterize the effects of aging on neuronal network physiology, particularly as it relates to processing input stimuli in short bursts of time. The use of MEG and MRI/MRS allows for information about spatial processing and neuronal function. A Planckian quantal approach to sensory processing was developed by the investigators. This protocol has been initiated and recruitment continues.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。本研究假设如下：1) 衰老大脑中动态神经元网络特性发生变化，影响感觉和认知处理；2) 这些变化可以通过脑磁图 (MEG) 进行量化。一般来说，虽然感觉处理发生在大脑的专用单元中，但认知结合过程因衰老过程而以时间依赖性方式改变，将导致感觉运动整合的改变。目标如下：1）对听觉诱发的丘脑皮质大脑活动的时间重置进行成像和分析。 2）研究正常人和老年人的心理物理体感阈值与初级感觉皮层神经活动的特定模式之间是否存在相关性。 3）对视觉诱发的丘脑皮质大脑活动的时间重置进行成像和分析。 4）分析语言感知加工及其随衰老的变化。将招募 165 名个体（25-80 岁，每 5 岁年龄组 15 人为一组），并接受神经心理学测试以及自发和感觉诱发的 MEG 测量，以检测与 4 个目标相关的刺激的重置和结合参数。 MEG 结果将叠加在 MRI/MRS 图像上，以揭示正常衰老过程中感觉和认知衰退的潜在神经生物学相关性。此外，度量和光谱参数将用于定义受试者之间的相似性分数以及个体分数。个人得分可以与神经心理学评估相关。临床和认知评估将每两年重复一次。患者招募将包括现有的患者群体，其次是 NIA 支持的纽约大学阿尔茨海默病中心。精神病学系还将提供特征良好、健康、认知正常的受试者。这是一个大胆的尝试，旨在描述衰老对神经网络生理学的影响，特别是因为它与在短时间内处理输入刺激有关。 MEG 和 MRI/MRS 的使用可以提供有关空间处理和神经元功能的信息。研究人员开发了一种用于感觉处理的普朗克量子方法。该协议已启动，招募仍在继续。