Fluid Structure Interactions Within the Human Larynx

人喉内的流体结构相互作用

• 批准号: 7082760
• 负责人: LUC MONGEAU
• 金额: $ 58.25万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7082760
• 关键词: biomechanics; computer program /software; computer simulation; digital imaging; fluid flow; larynx; mathematical model; model design /development; physical model; shear stress; sound; tissue support frame; vibration; viscosity; vocal cords; voice

DESCRIPTION (provided by applicant): This proposal describes a study of fluid-structure interaction phenomena within the human larynx during phonation. The motion of the vocal folds is driven in part by the aerodynamic pressure on their surfaces. During phonation, there is a periodic exchange of energy between the elastic deformation of the vocal folds and the surface pressures associated with the airflow through the larynx. A good understanding of the associated fluid-structure interaction mechanisms is of utmost importance in order to develop accurate predictive models of phonatory processes, and accurate estimates of the stresses within the tissue. The purpose of the proposed research is to gain a thorough understanding of the mechanics of fluid-induced oscillations of the laryngeal tissue, including aspects related to the possible role of the false vocal folds in phonation. The aims are to: 1) perform detailed flow, kinematic, and sound measurements using a self oscillating physical model of the larynx and the false vocal folds; 2) develop detailed and accurate computational models as well as approximate reduced order models for the prediction of fluid flow, radiated sound, and tissue deformation of the larynx and false folds; and 3) determine the effects on laryngeal dynamics of normal and pathological conditions of the larynx, and clarify the role of the false vocal folds. Fundamental phonation processes will be isolated and studied. The different theoretical and physical models will be used to cross-validate new information that bridges from idealized models and real larynx phonation. Comparisons will be made between data obtained using the physical models and the numerical predictions. This will allow the validation of the numerical models, and reinforce our understanding of the physical phenomena involved. The overarching goal is to develop accurate computer prediction models of voice production that may eventually be useful for making precise diagnostic decisions in the voice clinic, targeting optimal intervention strategies for voice problems, and achieving high quality articulatory speech synthesis. Accurate stress calculations are also needed and useful for tissue damage predictions. This research program is a collaboration among laboratories at Bowling Green State University and Purdue University.

描述（由申请人提供）：该提案描述了对发声期间人类喉部内的流体-结构相互作用现象的研究。声带的运动部分是由其表面的空气动力压力驱动的。在发声过程中，声带的弹性变形和与通过喉部的气流相关的表面压力之间存在周期性的能量交换。为了开发发声过程的准确预测模型以及组织内应力的准确估计，对相关流体-结构相互作用机制的良好理解至关重要。拟议研究的目的是彻底了解喉部组织流体引起的振荡的机制，包括与假声带在发声中可能发挥的作用相关的方面。目的是：1）使用喉和假声带的自振荡物理模型进行详细的流量、运动学和声音测量； 2）开发详细而准确的计算模型以及近似降阶模型，用于预测喉部和假襞的流体流动、辐射声以及组织变形； 3）确定正常和病理状态的喉部对喉动力的影响，并阐明假声带的作用。基本的发声过程将被分离和研究。不同的理论和物理模型将用于交叉验证理想模型和真实喉部发声之间的新信息。将使用物理模型获得的数据与数值预测进行比较。这将有助于验证数值模型，并加强我们对所涉及物理现象的理解。总体目标是开发准确的语音产生计算机预测模型，最终可能有助于在语音诊所中做出精确的诊断决策，针对语音问题制定最佳干预策略，并实现高质量的发音合成。准确的应力计算也是必要的，并且对于组织损伤预测很有用。该研究项目是鲍灵格林州立大学和普渡大学实验室之间的合作。