PAIN MECHANISMS IN CHRONIC MULTI-SYMPTOM ILLNESSES

慢性多症状疾病的疼痛机制

• 批准号: 7376547
• 负责人: Richard H Gracely
• 金额: $ 2.96万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376547
• 关键词: aging; brain; chronic pain; ethnic group; experience; fibromyalgia; functional magnetic resonance imaging; irritable bowel syndrome; pain; questionnaires; sex; temperature; aging; brain; chronic pain; ethnic group; experience; fibromyalgia; functional magnetic resonance imaging; irritable bowel syndrome; pain; questionnaires; sex; temperature

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are many individuals who experience one or more forms of chronic pain in their everyday life. In particular, there are many illnesses that fall under an umbrella called Chronic Multi-symptom Illness (CMI). Such illnesses include, but are not limited to, fibromyalgia (FMS), irritable bowel syndrome (IBS), and temporomandibular disorder (TMD). In this study we will compare and contrast various physiologic findings in individuals who have FMS, IBS, or TMD and will compare and contrast these findings to individuals who have no chronic pain symptoms (controls). Study volunteers will take part in one or more testing session(s) where they will complete a detailed battery of tests and questionnaires involving self-report of pain levels and psychological and cognitive factors. In addition, different types of stimulation (pressure, temperature, electrical, auditory) will be performed to assess individual effects. People who take part in this study will also have a functional MRI scan to look at how pain is processed in the brain. A total of 144 age-, gender-, and race-matched subjects will be studied, 36 FM patients, 36 IBS patients, 36 TMD patients, and 36 controls. Study volunteers will be drawn from a pool of people who completed the Screening Protocol designed by our group. No ethnic groups will be excluded from this protocol.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。有许多人在日常生活中经历一种或多种形式的慢性疼痛。特别是，有许多疾病属于称为慢性多症状疾病（CMI）的雨伞。这种疾病包括但不限于纤维肌痛（FMS），肠易激综合征（IBS）和颞下颌疾病（TMD）。在这项研究中，我们将在具有FMS，IBS或TMD的个体中比较和对比各种生理发现，并将这些发现与没有慢性疼痛症状（对照）的个体进行比较和对比。研究志愿者将参加一个或多个测试会议，他们将完成一系列详细的测试和问卷调查，涉及疼痛水平以及心理和认知因素的自我报告。另外，将执行不同类型的刺激（压力，温度，电气，听觉）来评估个体效应。参加这项研究的人还将进行功能性MRI扫描，以研究大脑中疼痛的处理方式。总共将研究144名年龄，性别和种族匹配的受试者，36名FM患者，36名IBS患者，36名TMD患者和36例对照。研究志愿者将从完成我们小组设计的筛查协议的人群中获奖。该议定书中不会排除任何种族。