FLUORESCENT POLYMER CHEMOSENSORS

荧光聚合物化学传感器

• 批准号: 7373142
• 负责人: JONES E WAYNE
• 金额: $ 0.14万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7373142
• 关键词: FLUORESCENT; POLYMER; CHEMOSENSORS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have been investigating a new series of fluorescent, conjugated polymer materials that contain polyreceptor assemblies. The multiple receptor sites are electronically connected by the conjugated polymer (molecular wire) and exhibit larg sensitivity gains over more conventional molecule-based fluorescent chemosensors. These polymers have been found to respond quantitatively to transition metal ions at concentrations as low as 4*10-9 M. We have also developed a new method to create inorganic/organic hybrid polymers that respond through a "turn-on" fluorescence mechanism. This hybrid system is showing promising results for the selective detection of biological iron. In order to more completely characterize the dynamics of the fluorescent quenching process, time-resolved emission and transient absorption measurements are necessary. This is particularly important in light of the non-linear Stern-Volmer behavior of these polymers that can be attributed to a combination of energy transfer dynamics on the polymer backbone and more traditional static quenching. A specific photophysical goal will be to identify whether charge transfer products are formed during the quenching process.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。我们一直在研究一系列含有多心理组件的荧光，共轭聚合物材料。多个受体位点通过共轭聚合物（分子线）以电子方式连接，并表现出与更传统的基于分子的荧光化学传感器相比的敏感性。已经发现这些聚合物以低至4*10-9的浓度对过渡金属离子进行定量响应。我们还开发了一种新方法来创建无机/有机杂交聚合物，这些聚合物通过“转盘”荧光机制做出响应。该杂种系统在选择性检测生物铁的选择结果中显示出令人鼓舞的结果。为了更彻底地表征荧光猝灭过程的动力学，需要时间分辨的发射和瞬态吸收测量值。鉴于这些聚合物的非线性船尾伏仪行为尤其重要，这些行为可以归因于聚合物主链上的能量传递动力学和更传统的静态淬火的组合。特定的光物理目标是确定在淬火过程中是否形成了电荷传输产物。