Children at High and at Low Risk for Depression

抑郁症高风险和低风险儿童

• 批准号: 7157627
• 负责人: MYRNA M WEISSMAN
• 金额: $ 106.67万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7157627
• 关键词: Accounting; Adult; Amygdaloid structure; Anterior; Anxiety; Anxiety Disorders; Base of the Brain; Brain; Child; Childhood; Classification; Clinical; Clinical assessments; Cognitive; Data; Data Analyses; Data Set; Depressed mood; Disease; Dorsal; Family; Functional Magnetic Resonance Imaging; Funding; Generations; Hippocampus (Brain); Image; Individual; Lead; Left; Magnetic Resonance Imaging; Major Depressive Disorder; Measures; Mental Depression; Methods; Moods; Neurobiology; Onset of illness; Parents; Parietal; Parietal Lobe; Pattern; Population; Prefrontal Cortex; Problem behavior; Psychiatric Diagnosis; Psychophysiology; Puberty; Recording of previous events; Research Design; Risk; Sampling; Structure; System; Time; base; cingulate cortex; cohort; depressive symptoms; design; grandparent; neuroimaging; relating to nervous system; response; trait

DESCRIPTION (provided by applicant): The overall aim of this study has been to understand the long term temporal sequence and familial patterns of mood and other disorders from childhood to adulthood in offspring at high and low risk for depression. This study has had 4 waves of assessments. The last wave began in 12/98, 17 years after the initial assessment. This application is for Wave 5. The sample now includes 3 generations (grandparents, parents, and grandchildren). The basic design is one of families at high and low risk for depression based on the depression status of the original sample (1st generation -- the grandparents). Our previous findings in the offspring (2nd generation -- now the parents) showed both cross-sectionally and longitudinally that the offspring of depressed grandparents were at high risk (3-fold increase) for major depression. Their depression began early, often at puberty, and was preceded by prepubertal onset anxiety. The results for the 3rd generation (the grandchildren) again shows that the grandchildren in the high risk group (i.e., at least one depressed grandparent) are at increased risk of mood and anxiety disorders. These consistent findings across the generations lead directly to this new application which focuses on understanding the brain based correlates of familial depression. These results support the use of the original high and low risk classification which guide this renewal and its hypotheses. A new aim of the current application is to define the neural correlates of familial risk for depression in subjects in the 2nd and 3rd generations of this cohort using anatomical and functional MRI. This sample is uniquely valuable for identifying the neural correlates of familial risk because the study of high-risk populations prior to the onset of illness is likely to be the best way to distinguish cause from compensatory effect in neurobiological studies, and because psychiatric diagnoses established prospectively and across generations will provide the greatest possible confidence in the assessment of multi-generational familial risk. In addition, the availability of MRI data will provide us with the opportunity to understand better the underlying basis, in terms of brain structure and function, of the electrophysiological abnormalities identified in the last cyclic of funding. Our specific aims for this renewal are (1) to complete data analyses of the 4th wave assessment; (2) to acquire and analyze both anatomical and functional MRI in 214 subjects (118 second and 96 third generation) of this cohort; and (3) to conduct data analysis integrating findings of the clinical, psychophysiologic and neuroimaging studies.

描述（由申请人提供）：这项研究的总体目的是了解从童年到成年期的长期时间序列和家族性的情绪和其他疾病的抑郁风险。这项研究有4波评估。最后一波始于初步评估17年后的12/98。此应用程序是针对第5浪的。样本现在包括3代（祖父母，父母和孙子）。基本设计是基于原始样本的抑郁状态（第一代 - 祖父母）的抑郁状态，处于高和低风险的家庭。我们以前在后代（第二代 - 现在的父母）的发现在横截面和纵向上都表明，沮丧的祖父母的后代对重度抑郁症的风险高（3倍）。他们的抑郁症开始早起，通常是在青春期开始，然后是青春期前的焦虑。第三代（孙子）的结果再次表明，高风险群体中的孙子（即至少一个沮丧的祖父母）患有情绪和焦虑症的风险增加。这些世代相传的这些一致的发现直接导致了这一新应用，该应用集中在理解基于大脑的家族抑郁症的相关性。这些结果支持使用原始的高和低风险分类，该分类指导这种续约及其假设。当前应用的一个新目标是使用解剖学和功能性MRI定义该群体第二和第3代受试者抑郁症的神经相关性。该样本对于确定家族风险的神经相关性具有独特的价值，因为在疾病发作之前对高风险人群的研究可能是区分神经生物学研究中的原因的最佳方法，并且由于前瞻性和世代相传的精神病学诊断将在评估多种基因家庭风险的评估中最大程度地提供信心。此外，MRI数据的可用性将为我们提供更好地了解大脑结构和功能的基础，在最后一个融资中确定的电生理异常的基础。我们对这种续签的具体目的是（1）完成第四波评估的数据分析； （2）在214名受试者（118秒和96个第三代）中获取和分析该队列的解剖学和功能性MRI； （3）进行数据分析，整合了临床，心理生理和神经影像学研究的发现。