Whole-body 7 Tesla Magnetic Resonance Imaging System

全身7特斯拉磁共振成像系统

• 批准号: 7125818
• 负责人: Ravinder Reddy
• 金额: $ 200万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125818
• 关键词: anatomy; arthritis; bioimaging /biomedical imaging; bone; brain imaging /visualization /scanning; diffusion; gait; human; joints; lead; magnetic field; magnetic resonance imaging; magnetism; method development; molecular /cellular imaging; motivation; neoplasm /cancer; neuroimaging; noise; osteoporosis; performance; perfusion; physiology; radiology; tissues; university

DESCRIPTION (provided by applicant): Since the inception of MRI for clinical imaging and research over two decades ago, the magnetic field strength of clinical imagers has increased 20-fold from 0.15 Tesla (T) initially to 3T currently. The early recognition that image quality per unit scan time is largely determined by the intrinsic signal-to-noise ratio has driven the diffusion of commercial 3 Tesla systems which have set a new performance standard for clinical imaging. It is likely that the current trend will continue in that the next generation systems will operate at fields considerably above 3T. Initial results from a few laboratories suggest MRI and MRS at field strengths of 7-9T to have great promise by providing insight into structure, function and physiology in humans not obtainable at lower fields. Several leading institutions in the US and overseas either already have 7T whole-body systems or are on their way to acquiring ultrahigh-field scanners in the near future. However, currently there is no 7T whole-body system at the University of Pennsylvania nor are we aware of plans by neighboring institutions of commissioning such a system. In this proposal we request funds for the acquisition of a 7T whole-body MRI scanner in the Department of Radiology at the University of Pennsylvania Medical Center. We show that the proposed system will substantially enhance ongoing research in 34 R01s, one P41 and three program project grants at four centers: the Metabolic Magnetic Resonance Research and Computing Center (MMRRCC), the Center for Functional Neuroimaging (CfN), the Center for Molecular imaging (CEMI), and the Laboratory for Structural NMR Imaging (LSNI). Biomedical imaging research in these four laboratories covers a wide range of applications and new methods development involving functional brain imaging for basic and clinical neuroscience, the study of neurodegenerative and metabolic disorders, molecular imaging for cancer detection and treatment monitoring, novel approaches to cardiovascular disease and tissue perfusion, and joint and bone disease (arthritis and osteoporosis). The 7T system will be integrated into the Center for Advanced Magnetic Resonance Imaging and Spectroscopy (CAMRIS) at the University of Pennsylvania. The resource will be run by an Executive Committee (EC) under the auspices of the current CAMRIS Committee.

描述（由申请人提供）：自二十年前的临床成像和研究MRI成立以来，临床成像仪的磁场强度已从最初从0.15特斯拉（T）提高到目前的3T。早期认识到每单位扫描时间的图像质量在很大程度上取决于固有的信噪比，从而驱动了商业3特斯拉系统的扩散，该系统为临床成像设定了新的性能标准。当前的趋势可能会持续下去，下一代系统将在3T以上的田野上运行。一些实验室的最初结果表明，在7-9T的田间强度处的MRI和MRS通过提供对人类在较低田地无法获得的结构，功能和生理学的见解，具有巨大的希望。美国和海外的几个领先机构要么已经拥有7T全身系统，要么正在不久的将来购买超高场扫描仪。但是，目前宾夕法尼亚大学没有7T全身系统，我们也不知道邻近的调试这种系统的计划。在此提案中，我们要求资金在宾夕法尼亚大学医学中心放射学系的7T全身MRI扫描仪中收购。我们表明，提出的系统将在34个R01，一个P41和三个程序项目中实质上增强正在进行的研究：在四个中心授予：代谢磁共振研究与计算中心（MMRRCC），功能性神经影像中心，分子成像中心（CEMI）和实验室NMRRSNMRRMRRRRMRRRRMRRRMRRRMRRRRRMRRRRRMRRMRRMRRMRRMRMRRMRMRRMRRRMRRMRRRMRMRRMRRRSN。这四个实验室中的生物医学成像研究涵盖了涉及基本和临床神经科学功能性大脑成像的广泛应用和新方法，研究神经退行性和代谢性疾病的研究，用于癌症检测和治疗监测的分子成像，新颖的方法，用于心血管疾病疾病和组织灌注和关节疾病和骨病和骨病（Aropor）和骨骼疾病和骨骼和骨骼疾病（Aropor）和骨骼症。 7T系统将集成到宾夕法尼亚大学的晚期磁共振成像和光谱（CAMRIS）中心。该资源将由当前CAMRIS委员会的主持人执行委员会（EC）经营。