Age dependence of the BOLD signal in children and adults

儿童和成人 BOLD 信号的年龄依赖性

• 批准号: 7140457
• 负责人: WOLFGANG RICHTER
• 金额: $ 14.68万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7140457
• 关键词: adolescence (12-20); adult human (21+); age difference; bioimaging /biomedical imaging; brain circulation; clinical research; functional magnetic resonance imaging; hemodynamics; human subject; middle childhood (6-11)

DESCRIPTION (provided by applicant): FMRI measures brain activity through a secondary effect of neuronal activation, the BOLD effect, which comprises contributions from metabolism, blood flow, and blood volume, and which is not quantitatively understood in terms of these parameters. The time course of the BOLD signal is also somewhat variable from subject to subject, which tends to decrease statistical power of the experiment if the variability is random, and can lead to systematic errors if the variability is systematic. We have performed a pilot study of 28 children and adults, where we measured the shape of the hemodynamic response in a visual task. Unexpectedly, we found a systematic variation of the width of this function with age. We would now like to investigate this effect further. Specifically, we would like to determine the physiological origin of the systematic variability. To this end, we are planning to measure BOLD, blood flow, and blood volume in three groups of subjects (children, young adults, older adults) in response to a visual stimulation task, and to compare the results to known physiological differences between different age groups. Also, we would like to determine if an age-specific BOLD model function should generally be used to increase statistical power and to avoid bias in experiments where different age groups are compared.

描述（由申请人提供）：FMRI 通过神经元激活的次级效应（BOLD 效应）测量大脑活动，该效应包括新陈代谢、血流量和血容量的贡献，并且无法根据这些参数进行定量理解。 BOLD 信号的时间进程在不同受试者之间也有一定的变化，如果变化是随机的，这往往会降低实验的统计功效，如果变化是系统的，则可能导致系统误差。我们对 28 名儿童和成人进行了一项试点研究，测量了视觉任务中血流动力学反应的形状。出乎意料的是，我们发现该函数的宽度随着年龄的增长而出现系统性变化。我们现在想进一步研究这种影响。具体来说，我们想确定系统变异性的生理起源。为此，我们计划测量三组受试者（儿童、年轻人、老年人）对视觉刺激任务的 BOLD、血流量和血容量，并将结果与​​不同人群之间已知的生理差异进行比较。年龄组。此外，我们还想确定是否通常应使用特定于年龄的 BOLD 模型函数来提高统计功效并避免比较不同年龄组的实验中出现偏差。