Transmit/Receive Single Echo Acquisition MRI

发射/接收单回波采集 MRI

• 批准号: 7143613
• 负责人: Steven M Wright
• 金额: $ 25.44万
• 依托单位: TEXAS ENGINEERING EXPERIMENT STATION
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7143613
• 关键词: brain; fasting; fluid; measurement; microfluidics; orientation

DESCRIPTION (provided by applicant): The objective of this EBRG proposal is to develop Transmit/Receive Single Echo Acquisition (SEA) magnetic resonance imaging to enable imaging and flow measurements at extremely high temporal resolutions and over arbitrarily curved planes (linear only in the frequency encoding direction). The use of a T/R array will remove the need for a phase compensation pulse, a limitation in our earlier results using receive-only arrays. Therefore this new technique will be far more robust, enabling conformable arrays and 3D imaging. To achieve this objective, we will build a 64 channel, 30 watt per channel transmitter. In parallel, we will evaluate five candidate array element designs for optimal combination of penetration depth and decoupling, and then construct 64 channel planar and cylindrical arrays. Finally, we will develop, test, and evaluate T/R SEA MRI of flow using phase contrast and spin-tagging methods on conventional and microfluidic phantoms with periodic and non-periodic flow. If successful, this study will have developed a new methodology capable of MR imaging at unprecedented frame rates (500 frames/second) over arbitrarily curved slices. The method will provide a true "snapshot" flow imaging method, capable of imaging one-time events such as transient waves being investigated for MR elastography or non-periodic flow such as in stenotic vessel models. The conformable arrays will be applicable in catheter based interventional MRI and detecting rapid responses in fMRI of the brain surface. Of particular interest in this study is the use of T/R SEA flow measurement for characterization of microfluidic lab-on-a-chip devices. Methods are being investigated to create chaotic flow patterns in these devices, which can decrease mixing times by several orders of magnitude, critical for molecular diagnostics and drug development. The methods proposed here could provide a new tool for characterization of chaotic flow in these devices relying purely on endogenous contrast, eliminating the need for optical windows or seeding for optical reflection.

描述（由申请人提供）：该 EBRG 提案的目标是开发发射/接收单回波采集 (SEA) 磁共振成像，以实现在极高时间分辨率和任意曲面（仅在频率上呈线性）下的成像和流量测量编码方向）。 T/R 阵列的使用将消除对相位补偿脉冲的需要，这是我们早期使用仅接收阵列的结果中的一个限制。因此，这项新技术将更加稳健，能够实现一致的阵列和 3D 成像。为了实现这一目标，我们将构建一个 64 通道、每通道 30 瓦的发射器。同时，我们将评估五种候选阵列元件设计，以实现穿透深度和去耦的最佳组合，然后构建 64 通道平面和圆柱形阵列。最后，我们将使用相差和自旋标记方法在具有周期性和非周期性流动的传统和微流体体模上开发、测试和评估流动的 T/R SEA MRI。如果成功，这项研究将开发出一种新的方法，能够以前所未有的帧速率（500 帧/秒）在任意弯曲的切片上进行 MR 成像。该方法将提供一种真正的“快照”流成像方法，能够对一次性事件进行成像，例如用于磁共振弹性成像研究的瞬态波或非周期性流（例如狭窄血管模型）。适形阵列将适用于基于导管的介入 MRI 并检测大脑表面 fMRI 的快速响应。本研究特别感兴趣的是使用 T/R SEA 流量测量来表征微流体芯片实验室设备。正在研究在这些设备中创建混沌流模式的方法，这可以将混合时间减少几个数量级，这对于分子诊断和药物开发至关重要。这里提出的方法可以提供一种新的工具来表征这些设备中的混沌流，完全依赖于内生对比度，消除了对光学窗口或光学反射种子的需要。