Very-High-Frequency Ultrasound Imaging With Coded Signals and Annular Arrays

使用编码信号和环形阵列进行甚高频超声成像

• 批准号: 7267918
• 负责人: JONATHAN MAMOU
• 金额: $ 18.33万
• 依托单位: RIVERSIDE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7267918
• 关键词: Algorithms; Anatomy; Anterior eyeball segment structure; Arts; Choroid; Choroid Neoplasms; Ciliary Body; Clinical; Code; Coma; Cyst; Depth; Diagnostic Imaging; Disease Management; Disease Progression; Disease regression; Electronics; Elements; Evaluation; Eye; Frequencies; Glaucoma; Hemorrhage; Image; Invasive; Iris Neoplasms; Lead; Macular degeneration; Medical Imaging; Membrane; Methodology; Methods; Monitor; Mucous Membrane; Noise; Normal tissue morphology; Numbers; Ophthalmology; Optic Nerve; Pathology; Penetration; Physiologic pulse; Pulse taking; Range; Research; Resolution; Retina; Retinal Neoplasms; Scanning; Signal Transduction; Skin; Techniques; Technology; Testing; Theoretical model; Tissues; Transducers; Ultrasonic wave; Ultrasonography; attenuation; clinical application; computerized data processing; concept; corneal scar; design; gastrointestinal; gastrointestinal imaging; improved; interest; medical specialties; performance tests; programs; tool; Algorithms; Anatomy; Anterior eyeball segment structure; Arts; Choroid; Choroid Neoplasms; Ciliary Body; Clinical; Code; Coma; Cyst; Depth; Diagnostic Imaging; Disease Management; Disease Progression; Disease regression; Electronics; Elements; Evaluation; Eye; Frequencies; Glaucoma; Hemorrhage; Image; Invasive; Iris Neoplasms; Lead; Macular degeneration; Medical Imaging; Membrane; Methodology; Methods; Monitor; Mucous Membrane; Noise; Normal tissue morphology; Numbers; Ophthalmology; Optic Nerve; Pathology; Penetration; Physiologic pulse; Pulse taking; Range; Research; Resolution; Retina; Retinal Neoplasms; Scanning; Signal Transduction; Skin; Techniques; Technology; Testing; Theoretical model; Tissues; Transducers; Ultrasonic wave; Ultrasonography; attenuation; clinical application; computerized data processing; concept; corneal scar; design; gastrointestinal; gastrointestinal imaging; improved; interest; medical specialties; performance tests; programs; tool

DESCRIPTION (provided by applicant): Ultrasound at very-high-frequency provides non-invasive diagnostic imaging with resolution better than 100 urn. Very-high-frequency ultrasound (VHFU) is of great interest for imaging superficial tissues, such as skin, eye, gastrointestinal mucosa, and arterial plaque. The two main limiting factors for VHFU are the small depth of field and the frequency-dependent attenuation. The small depth of field allows fine-resolution images over only a small axial range about the focus, and the frequency-dependent attenuation limits application of VHFU to shallow imaging. We propose to develop signal-processing and VHFU imaging strategies that will mitigate these two limiting factors. Specifically, we will combine coded-excitation algorithms with annular-array technologies. The specific design of coded signals for VHFU will increase signal-to-noise ratio (SNR), which will permit an increased depth of penetration of VHFU waves. VHFU annular arrays allow dynamic focusing that can significantly increase the depth of field without requiring the large number of elements needed in linear arrays; this greatly simplifies electronics and facilitates implementation for clinical scanning. Coded excitation in ultrasound has never been investigated at very high- frequencies nor has it been combined with state-of-the-art annular arrays. We plan to extend the methodologies to obtain quantitative information about tissue microstructures. This quantitative ultrasound information will lead to a new means of distinguishing diseased from normal tissue and of monitoring disease progression or regression. While the technology and methodology to be developed in this project have general applicability for imaging superficial tissues, this research program will be developed in the context of ophthalmology. The proposed research can lead to significant improvement in evaluation of ophthalmic pathologies such as glaucoma, vitreous membranes, hemorrhage, choroidal tumors, and retinal and choroidal detachment that are challenging to image with conventional high-frequency ultrasound. If successful, the proposed research also will lead to significant improvement of diagnostic ultrasound in other clinical specialties. It will allow obtaining medical images with exquisite resolution, increased depth of field and a greater depth of penetration, and lead to new capabilities for improved diagnostic imaging and disease management.

描述（由申请人提供）：在非常高的频率上进行超声波提供了非侵入性诊断成像，分辨率大于100 urn。高频超声（VHFU）对成像浅表组织（例如皮肤，眼睛，胃肠道粘膜和动脉斑块）具有极大的兴趣。 VHFU的两个主要限制因素是景深很小和频率依赖性衰减。较小的景深允许仅在焦点上的小轴向范围内进行精细分辨率图像，而频率依赖性衰减限制了VHFU在浅成像中的应用。我们建议开发信号处理和VHFU成像策略，以减轻这两个限制因素。具体而言，我们将将编码示例算法与环形阵列技术相结合。 VHFU的编码信号的特定设计将增加信噪比（SNR），这将使VHFU波的穿透深度增加。 VHFU环形阵列允许动态焦点可以显着增加景深，而无需线性阵列中所需的大量元素；这极大地简化了电子产品并促进实施临床扫描。超声波中的编码激发从未以非常高的频率进行研究，也没有与最新的环形阵列相结合。我们计划扩展方法，以获取有关组织微观结构的定量信息。此定量超声信息将导致一种新的方法，将患病与正常组织和监测疾病进展或消退。尽管该项目要开发的技术和方法具有一般适用于成像表面组织，但该研究计划将在眼科的背景下制定。拟议的研究可以导致对眼科病理的评估显着改善，例如青光眼，玻璃膜膜，出血，脉络膜肿瘤以及视网膜和脉络膜脱离，这些脱离具有挑战性，具有传统的高频超声波。如果成功，拟议的研究还将导致其他临床专业的诊断超声波显着改善。它将允许以精美的分辨率获得医学图像，景深增加和更大的穿透深度，并为改善诊断成像和疾病管理的新功能提供了新的功能。