Repiratory Health and Community Asbestos Exposure

呼吸系统健康和社区石棉接触

• 批准号: 7278253
• 负责人: Bruce H. Alexander
• 金额: $ 35万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2009-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7278253
• 关键词: Repiratory; Health; Community; Asbestos; Exposure; Repiratory; Health; Community; Asbestos; Exposure

Asbestos is a known causal factor for lung cancer, asbestosis, and mesothelioma. These associations are well established in occupationally exposed populations, however the risks at lower environmental exposures are not clear. The mission of the ATSDR includes developing the knowledge base related to understanding the effects of hazardous substances, like asbestos, on human health. The proposed research builds on previous worked funded by the ATSDR evaluating an asbestos contaminated environment. From 1938-1989 a densely populated urban residential neighborhood in Minneapolis MN experienced significant environmental asbestos exposure from processing asbestos contaminated vermiculite ore from Libby Montana at the Western Minerals/WR Grace facility. Waste rock from the processing plant was distributed widely around the neighborhood and children in the neighborhood frequently played on the piles of waste rock. The Minnesota Department of Health in cooperation with the ATSDR has established a roster of current and former residents of the neighborhood and have made initial estimates of exposure to this population. The long-term goal of this research effort is to determine the extent to which asbestos exposure from contaminated ore at the WM/WRG facility in Minneapolis resulted in adverse health consequences to workers and members of the surrounding community. The proposed research will focus on non-occupational exposure in the community. The following hypotheses will be addressed in this research. 1. Non-occupational exposure to asbestos contaminated vermiculite products and waste products is associated with increased prevalence of non-malignant asbestos related respiratory disease, specifically pleural abnormalities, in the members of the Northeast Minneapolis Community Vermiculite Investigation Cohort. 2. Exposure during childhood is more strongly related to onset of non-malignant respiratory disease. A sample of 600 of the identified residents will be selected based on probability of exposure. A respiratory screening protocol for detection of non-malignant respiratory abnormalities (radiographic and spirometry) consistent with asbestos exposure will establish prevalent asbestos related respiratory disease. The prevalence of these conditions will be compared on the basis of estimated asbestos exposure while controlling for potentially confounding covariates. Analyses will consider cumulative exposure and short, intense periods of exposure, with specific reference to exposure in childhood.

石棉是肺癌，石棉和间皮瘤的已知因果因子。这些关联是 在职业裸露的人群中建立了良好 不清楚。 ATSDR的使命包括建立与理解有关的知识基础 危险物质（如石棉）对人类健康的影响。拟议的研究以 以前的工作由ATSDR资助，评估了石棉污染的环境。 从1938 - 1989 从加工石棉污染的果石中，从 西方矿物/WR Grace设施的Libby Montana。加工厂的废石是 在附近地区广泛分发，附近的孩子经常在一堆 废岩。明尼苏达州卫生部与ATSDR合作已建立了一个名册 该社区的现任和前任居民，对此进行了初步估计 人口。 这项研究工作的长期目标是确定石棉暴露于多大程度上 明尼阿波利斯的WM/WRG设施受到污染的矿石，给工人带来了不利的健康后果 和周围社区的成员。拟议的研究将重点放在非职业曝光上 在社区。这项研究将解决以下假设。 1。非占有地暴露于石棉污染的ver虫产品和废物的产品是 与非恶性石棉相关呼吸道疾病的患病率增加有关，特别是 胸膜异常，在明尼阿波利斯东北部社区的成员中 队列。 2。儿童期的暴露与非恶性呼吸道疾病的发作更密切相关。 将根据暴露概率选择600个已确定的居民的样本。呼吸道 检测非恶性呼吸异常（射线照相和肺活量法）的筛查方案 与石棉暴露一致将建立普遍的石棉相关呼吸系统疾病。这 这些疾病的患病率将根据估计的石棉暴露进行比较 控制潜在的混淆协变量。分析将考虑累积​​暴露且短暂， 强烈的暴露期，特别是童年时期的暴露。