Cold Sintering of Advanced Ceramics and Glass along with Natural Sustainable Materials for Bone Tissue Engineering

先进陶瓷和玻璃以及天然可持续材料的冷烧结用于骨组织工程

• 批准号: 2891030
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2891030
• 关键词: Cold; Sintering; Advanced; Ceramics; Glass

Traditionally, sintering to create dense products requires heat treatment up to 80% of the melting temperature (Tm) to promote the transport of material to eliminate pores. Such high temperatures are costly in terms of energy and restrictive in the manufacture of ceramics devices which often require integration of polymers that suffer from volatility, melting, oxidation, interaction, and mismatch in thermal expansion with the ceramic. Professor Reaney has carried out in depth research on cold sintering of ceramics and devices, a patent (P100343WO01) has been filed which includes the consolidation of Bioglass and Bioglass/polymer composites at ~100oC. This will allow the development of composites with high filler content and also inclusion of polymer matrices such as Poly(3-hydroxybutyrate), a highly biocompatible and sustainable polymer of bacterial origin which melt at 170oC, without any degradation. These composites will lead to the development of relatively higher load bearing implants for bone tissue engineering. Currently no such biocompatible and bioresorbable polymer-based implant is available for a tissue engineering approach to load bearing applications such as shoulder and hip replacement/regeneration.

传统上，烧结以制造致密产品需要进行高达熔化温度 (Tm) 80% 的热处理，以促进材料的传输以消除孔隙。如此高的温度在能源方面是昂贵的，并且在陶瓷器件的制造中受到限制，陶瓷器件通常需要集成遭受挥发、熔化、氧化、相互作用以及与陶瓷热膨胀不匹配的聚合物。 Reaney教授对陶瓷和器件的冷烧结进行了深入研究，已申请专利（P100343WO01），其中包括生物玻璃和生物玻璃/聚合物复合材料在~100oC下的固结。这将允许开发具有高填料含量的复合材料，并包含聚合物基质，例如聚（3-羟基丁酸酯），这是一种高度生物相容性和可持续的细菌来源聚合物，在 170oC 时熔化，不会发生任何降解。这些复合材料将导致用于骨组织工程的相对较高负载的植入物的开发。目前，还没有这种基于生物相容性和生物可吸收性聚合物的植入物可用于组织工程方法来承载应用，例如肩部和髋部置换/再生。