Cold Sintering of Advanced Ceramics and Glass along with Natural Sustainable Materials for Bone Tissue Engineering

先进陶瓷和玻璃以及天然可持续材料的冷烧结用于骨组织工程

• 批准号: 2891030
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2891030
• 关键词: Cold; Sintering; Advanced; Ceramics; Glass

Traditionally, sintering to create dense products requires heat treatment up to 80% of the melting temperature (Tm) to promote the transport of material to eliminate pores. Such high temperatures are costly in terms of energy and restrictive in the manufacture of ceramics devices which often require integration of polymers that suffer from volatility, melting, oxidation, interaction, and mismatch in thermal expansion with the ceramic. Professor Reaney has carried out in depth research on cold sintering of ceramics and devices, a patent (P100343WO01) has been filed which includes the consolidation of Bioglass and Bioglass/polymer composites at ~100oC. This will allow the development of composites with high filler content and also inclusion of polymer matrices such as Poly(3-hydroxybutyrate), a highly biocompatible and sustainable polymer of bacterial origin which melt at 170oC, without any degradation. These composites will lead to the development of relatively higher load bearing implants for bone tissue engineering. Currently no such biocompatible and bioresorbable polymer-based implant is available for a tissue engineering approach to load bearing applications such as shoulder and hip replacement/regeneration.

传统上，烧结以创造致密产品需要高达80％的熔化温度（TM）的热处理，以促进材料的运输以消除毛孔。在能量和限制性方面，这种高温在制造陶瓷设备方面通常需要整合遭受挥发性，融化，氧化，相互作用和与陶瓷热膨胀中不匹配的聚合物的整合。 Reaney教授已经对陶瓷和设备的冷烧结进行了深入研究，已提交了专利（P100343WO01），其中包括bioglass和Bioglass和Bioglass/Bioglass/Polymer Composites的合并。这将允许开发具有较高填充物的复合材料，并包括聚合物基质（例如聚合物基质），例如聚（3-羟基丁酸），这是一种高度生物相容性且可持续的细菌起源聚合物，在170oC中融化，而没有任何降解。这些复合材料将导致用于骨组织工程的相对较高的负载轴承植入物的发展。目前，尚无这样的生物相容性和可生物吸附的基于聚合物的植入物，可用于组织工程方法，用于负载轴承应用，例如肩部和髋关节置换/再生。