Training Grant in Neurobehavioral Genetics

神经行为遗传学培训补助金

• 批准号: 7236183
• 负责人: DANIEL H GESCHWIND
• 金额: $ 17.51万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7236183
• 关键词: Genetic; Grant; Training; neurobehavioral

DESCRIPTION (provided by applicant): This proposal aims to provide funding for a pre-doctoral training program in Neurobehavioral Genetics (NBG). The completion of human genome sequencing provides an extraordinary opportunity to identify the genetic basis of disorders of brain function. Progress in this endeavor will be speeded by bridging several longstanding dichotomies; between nervous system mechanisms and behavior, between neurology and psychiatry/psychology, between diseases and non-disease traits, and between humans and model organisms. The goal of this proposal is to achieve such bridging by providing a unified and multidisciplinary training to PhD candidates from a wide range of backgrounds, including neuroscience, psychology, human genetics, neuroimaging, and pharmacology. If funded, this program would be the only training program focusing on mammalian or complex genetics at UCLA, thus serving a critical training niche for a large number of students from a variety of primary disciplines. Integrated training in genomics, neuroscience and phenomics is a critical step in the development of efficient, higher throughput genetic investigation of brainrelated phenotypes. The program will emphasize the importance of systematic delineation and assessment of nervous system phenotypes, including the integration of traditional clinical and cognitive evaluations with recently available phenotyping tools such as neuroimaging and gene expression profiling. This predoctoral training program will be closely integrated with a post-doctoral NBG training program which we anticipate will be funded through a T32 grant from NINDS beginning in 2004. The interactions of predoctoral students with postdoctoral fellows and faculty from disciplines that they would ordinarily not interact with in their primary department or program through the shared coursework and seminar series will provide a unique and special training environment for these predoctoral candidates. The ambitious goals of the program are achievable because the program faculty is very strong in virtually all of the areas that are relevant to neurobehavioral genetics, and because the faculty members have long embraced, in their research, the integrative and crossdisciplinary approach that is at the heart of the program.

描述（由申请人提供）：该提案旨在为神经行为遗传学（NBG）的博物前培训计划提供资金。人类基因组测序的完成提供了一个非凡的机会，以识别脑功能障碍的遗传基础。通过桥接几个长期存在的二分法，将加快这项努力的进展。神经系统机制和行为，神经病学与精神病学/心理学，疾病和非疾病特征之间以及人类与模型生物之间的之间。该提案的目的是通过向来自各种背景的博士候选人提供统一的多学科培训来实现此类桥梁，包括神经科学，心理学，人类遗传学，神经影像学和药理学。如果获得资助，该计划将是唯一关注UCLA哺乳动物或复杂遗传学的培训计划，从而为来自各种主要学科的大量学生提供关键的培训生态位。基因组学，神经科学和现象学方面的综合培训是开发有效，更高吞吐量遗传研究的关键步骤。该计划将强调系统性描述和对神经系统表型的评估的重要性，包括将传统的临床和认知评估与最近可用的表型工具（例如神经成像和基因表达谱分析）的整合。这项专业培训计划将与博士后NBG培训计划紧密融合，我们预计，我们将通过2004年开始的NINDS的T32赠款来资助，该计划从2004年开始。与博士后研究员的互动和学科的教职员工的互动，他们将通过其主要部门或共享系列中的各个部门与他们提供的唯一系列及其独特的系列互动，并提供这些独特的系列及其唯一的系列。候选人。该计划的雄心勃勃的目标是可以实现的，因为该计划的教师在几乎所有与神经行为遗传学相关的领域都非常强大，并且由于教职员工在研究中长期以来一直在研究，这是该计划核心的综合和跨学科方法。