2007 Protein Transport Across Membranes Gordon Conference

2007 年蛋白质跨膜转运戈登会议

• 批准号: 7273965
• 负责人: Carla M Koehler
• 金额: $ 0.8万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7273965
• 关键词: Academia; Address; Area; Bacteria; Biochemical Genetics; Biology; Cell membrane; Cells; Complex; Disease; Employee Strikes; Eukaryotic Cell; Future; Goals; Government; Human; Industry; Infection; Inherited; Italy; Lateral; Lipid Bilayers; Lipids; Localized; Location; Maintenance; Membrane; Membrane Proteins; Mitochondria; Organelles; Participant; Permeability; Postdoctoral Fellow; Protein translocation; Proteins; Range; Regulation; Request for Proposals; Research; Role; Scientist; Site; Structure; Students; System; Therapeutic; Virus; Work; novel; peroxisome; posters; protein transport; structural genomics; symposium; Academia; Address; Area; Bacteria; Biochemical Genetics; Biology; Cell membrane; Cells; Complex; Disease; Employee Strikes; Eukaryotic Cell; Future; Goals; Government; Human; Industry; Infection; Inherited; Italy; Lateral; Lipid Bilayers; Lipids; Localized; Location; Maintenance; Membrane; Membrane Proteins; Mitochondria; Organelles; Participant; Permeability; Postdoctoral Fellow; Protein translocation; Proteins; Range; Regulation; Request for Proposals; Research; Role; Scientist; Site; Structure; Students; System; Therapeutic; Virus; Work; novel; peroxisome; posters; protein transport; structural genomics; symposium

DESCRIPTION (provided by applicant): This proposal requests support for the 2nd Protein Transport Across Cell Membranes Gordon Research Conference (GRC), to be held June 10-15, 2007 at GRC site Il Ciocco in Italy. This new meeting will focus on the latest discoveries that enhance our understanding of the mechanisms by which proteins are transported across or integrated into membranes in eukaryotic cells, bacteria and organelles (e.g., mitochondria and peroxisomes). Since >25% of all proteins in all cells must cross at least one membrane to be correctly localized, protein translocation is one of the most fundamental problems in biology. The conference will address a wide range of topics including 1) the selection of proteins for translocation and their targeting to translocation sites, 2) the structure, function and assembly of translocation complexes and insertases, 3) reverse or retro-translocation, 4) constraints on the folded state of translocation substrates, 5) the maintenance of permeability barriers, 6) lateral transfer of membrane proteins into lipid bilayers, 7) the role of lipids in protein translocation and membrane protein integration, 8) the role of energy in protein transport, 9) the regulation of protein translocation and 10) novel protein translocation mechanisms. One of the main goals of this conference is to promote interactions among scientists who use diverse biochemical, genetic, genomic and structural approaches to understand fundamental mechanisms of protein transport across membranes. In addition, this conference will expose junior scientists to a broad range of experimental systems and problems in which understanding protein translocation and assembly is critical. This conference was established primarily to compensate for a striking dearth of formal opportunities for scientists who work on different but conceptually or mechanistically related aspects of protein translocation to meet and exchange ideas. The participants at the Protein Transport Across Cell Membranes Gordon Conference will include the leaders in the field, drawn from academia, government and industry, as well as more junior scientists, including many graduate students and postdoctoral fellows who represent the future in this area. A major use of the support sought in this application is to assist such junior scientists to participate in the meeting. The Gordon Conferences are organized to maximize opportunities for discussion and for the presentation of the latest findings in the field, with poster sessions occurring every afternoon and discussion periods after each formal session. This conference brings together scientists to discuss basic mechanisms of how a cell assembles and how proteins reach their correct location. This conference will discuss topics related to inherited diseases as well as ways in with bacteria and viruses may cause infection in humans. As a result, this conference leads to an increased understanding in the cause of disease and potential therapeutic approaches.

描述（由申请人提供）：该提案要求2007年6月10日至15日在意大利的GRC网站IL Ciocco举行，对跨细胞膜戈登研究会议（GRC）的第二蛋白运输的支持。这次新会议将集中于最新发现，以增强我们对蛋白质跨或整合到真核细胞，细菌和细胞器（例如线粒体和过氧化物酶体）中的膜中的机制的理解。由于所有细胞中所有蛋白质中的25％> 25％必须越过至少一个膜才能正确局部，因此蛋白质易位是生物学中最基本的问题之一。 The conference will address a wide range of topics including 1) the selection of proteins for translocation and their targeting to translocation sites, 2) the structure, function and assembly of translocation complexes and insertases, 3) reverse or retro-translocation, 4) constraints on the folded state of translocation substrates, 5) the maintenance of permeability barriers, 6) lateral transfer of membrane proteins into lipid bilayers, 7) the脂质在蛋白质易位和膜蛋白整合中的作用，8）能量在蛋白质转运中的作用，9）蛋白质转运的调节和10）新型蛋白质易位机制。这次会议的主要目标之一是促进使用多种生化，遗传，基因组和结构方法的科学家之间的相互作用，以了解跨膜蛋白质转运的基本机制。此外，这次会议将使初级科学家接触到广泛的实验系统，并了解理解蛋白质易位和组装至关重要的问题。这次会议主要是为了弥补与蛋白质易位在不同但概念或机械上相关的方面工作以满足和交流思想的科学家的严重缺乏的正式机会。跨细胞膜戈登会议的蛋白质运输的参与者将包括学术界，政府和工业的领导者，以及更多的初级科学家，包括许多代表该领域未来的研究生和博士后研究员。在本申请中寻求的支持的主要用途是协助这样的初级科学家参加会议。戈登会议的组织是为了最大程度地讨论和介绍该领域的最新发现，每天下午举行海报会议，每次正式会议之后进行讨论期。 这次会议汇集了科学家，讨论细胞组装以及蛋白质如何达到其正确位置的基本机制。该会议将讨论与遗传疾病有关的主题，以及与细菌和病毒有关的方式可能引起人类感染。结果，这次会议导致人们对疾病和潜在治疗方法的理解有所增加。