IOWA AND MISSOURI RADON LUNG CANCER STUDIES

爱荷华州和密苏里州氡气肺癌研究

基本信息

批准号：
7501832
负责人：
Robert William Field
金额：
$ 1万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-01-17 至 2007-12-31
项目状态：
已结题

项目摘要

Risk estimates, extrapolated from studies of underground miners, predict that residential radon progeny exposure accounts for approximately 19,000 lung cancer deaths each year in the United States. Previous case-control epidemiologic studies, which examined the relationship between residential radon exposure and lung cancer, lacked the ability to verify these risk estimates. Inaccurate dose assessment of radon exposure, a high percentage of proxy respondents, inadequate pathologic review, and low residential radon concentrations led to exposure misclassification and limited the interpretation of these studies. The Iowa Radon Lung Cancer Phase I study was designed to overcome many of these limitations. The Phase I study utilized advanced radon dose assessments, independent histologic review, and a study population that was characterized by geographic stability, high percentage of live cases, and potential for high radon exposure. The Phase I study demonstrated that exposure to residential radon gas increases the risk of developing lung cancer. To refine these estimates, we now propose Phase II studies that examine the association between residential radon product (progeny) exposure and the development of lung cancer. Because radon progeny deliver the actual radiation dose to the lung tissues, rather than radon gas itself, in order to reduce further the exposure misclassification, radon dose estimates need to take into account exposure to residential radon progeny. This requires measuring actual airborne radon progeny concentrations and integrating the exposure to radon progeny over time. The Phase II study will derive more accurate retrospective radon dose estimates by using a novel retrospective radon progeny integrating glass-based detector. Specific Aim I examines the hypothesis that exposure to residential radon progeny is associated with increased risk of developing lung cancer, after controlling for confounders. We will perform field calibration and laboratory validation of the retrospective radon "glass" detectors, and analyze the risk estimates by incorporating exposures to radon progeny, rather than exposures to radon gas. Specific Aim II will determine whether the shape of the dose response curve that best describes the relationship between residential radon progeny exposure and lung cancer risk is linear or nonlinear. Specific Aim III will examine whether exposure to radon progeny contributes to the development of adenocarcinoma, as well as other lung cancer histologic types. For Aims II and III we will use pooled analyses of exposure estimates that are derived from retrospective radon progeny "glass" detectors for subjects from the Iowa and Missouri Radon Lung Cancer Studies. The pooling of data between two large-scale epidemiologic studies from a similar geographic area, Iowa and Missouri, will allow us to increase sample size and statistical power.

从地下矿工研究推断出的风险估计值可以预测，在美国，住宅ra子的暴露每年约为19,000个肺癌死亡。先前研究了病例对照的流行病学研究，研究了住宅ra暴露与肺癌之间的关系，缺乏验证这些风险估计值的能力。不准确的剂量评估ra暴露，高比例受访者的比例不足，病理审查不足和居民ra浓度较低导致暴露误差，并限制了对这些研究的解释。爱荷华州伦敦肺癌I期研究旨在克服许多此类局限性。第一阶段研究利用了高级ra剂量评估，独立的组织学评论以及以地理稳定性，高比例的实时病例和高ra暴露的潜力为特征的研究人群。第一阶段的研究表明，暴露于住宅ra气会增加患肺癌的风险。为了完善这些估计，我们现在提出了II期研究，该研究研究了住宅ra（后代）暴露与肺癌发展之间的关联。由于ra子后代将实际的辐射剂量输送到肺组织而不是ra剂量本身，以便进一步减少暴露不分类，因此ra剂量的估计值需要考虑到住宅ra子后代的暴露。这需要测量实际的空气中ra子后代浓度，并随着时间的推移整合了暴露于ra ra的暴露。 II期研究将通过使用新型的回顾性ra子后代基于玻璃基于玻璃的检测器来得出更准确的回顾性ra剂量估计。具体目的我研究了一个假设，即在控制混杂因素后，暴露于住宅ra子后代与增加肺癌的风险增加有关。我们将对回顾性ra“玻璃”探测器进行现场校准和实验室验证，并通过纳入对ra ra的后代的暴露，而不是暴露于ra的气体来分析风险估计。具体的目标II将确定最能描述住宅ra ra剂量暴露与肺癌风险之间关系的剂量反应曲线的形状是线性还是非线性。特定的目标III将检查暴露于ra后代的暴露是否有助于腺癌的发展以及其他肺癌组织学类型。对于AIMS II和III，我们将使用汇总的暴露估计分析，这些估计值是从爱荷华州和密苏里州伦敦肺癌研究受试者的回顾性ra子后代“玻璃”探测器中得出的。来自爱荷华州和密苏里州类似地理区域的两项大规模流行病学研究之间的数据汇总将使我们能够增加样本量和统计能力。