Multispectral II-Plate Diffuse Optical Breast Tomography

多光谱 II 板漫反射光学乳腺断层扫描

• 批准号: 7270653
• 负责人: ARJUN G. YODH
• 金额: $ 42.26万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7270653
• 关键词: Air; Algorithms; Basic Science; Biopsy; Bite; Blood; Blood Vessels; Breast; Calibration; Cancer Patient; Cell Nucleus; Characteristics; Chest wall structure; Clinical; Clinical Data; Clinical Research; Computer software; Condition; Contrast Media; Coupling; Data; Data Set; Depth; Detection; Devices; Diagnostic; Diffuse; Disease; Engineering; Fat emulsion; Fiber Optics; Goals; Grant; Hemoglobin; Image; In Situ; Invasive; Lasers; Light; Lipids; Magnetic Resonance Imaging; Mammary Gland Parenchyma; Mammary Neoplasms; Mammography; Measurable; Measurement; Methods; Monitor; Morphologic artifacts; Nature; Neoadjuvant Therapy; Nonionizing Radiation; Numbers; Operative Surgical Procedures; Optical Image Reconstruction; Optical Methods; Optics; Other Imaging Modalities; Oxygen; Pathologist; Patients; Pennsylvania; Pharmaceutical Preparations; Physiological; Physiology; Pilot Projects; Platelet Factor 4; Pliability; Population; Positioning Attribute; Prior Chemotherapy; Process; Property; Purpose; Range; Rate; Relative (related person); Research; Resolution; Risk; Sampling; Sensitivity and Specificity; Shapes; Side; Source; Specific qualifier value; Speed; Staging; Surgeon; Techniques; Testing; Time; Tissues; Tomogram; Translations; Ultrasonography; University Hospitals; Variant; Water; Work; absorption; base; charge coupled device camera; chemotherapy; chromophore; density; design; detector; diffuse optical tomography; image reconstruction; improved; instrument; intravenous injection; malignant breast neoplasm; optical imaging; parallel computing; radiologist; reconstruction; response; simulation; size; success; tomography; transmission process; tumor

DESCRIPTION (provided by applicant): The long-range goal of this competing continuation grant is to assess and improve the breast tumor diagnostic capabilities of diffuse optical tomography with near infrared light. Near-infrared diffuse optical tomography is based on the study of functional processes, and provides several unique measurable parameters with potential to enhance breast tumor sensitivity and specificity. The techniques utilize non-ionizing radiation, are non-invasive, and are technologically simple and fast. Tissue optical absorption coefficients provide access to blood dynamics, total hemoglobin concentration, blood oxygen saturation, water concentration and lipid content. These tissue properties are often substantially different in rapidly growing tumors. During this proposal cycle we assembled a parallel-plate soft-compression apparatus for diffuse optical tomography of breast, and we have began pilot clinical studies with the instrument at the Hospital of the University of Pennsylvania. Our pilot studies have clearly shown tumors are detectable and characterizable with the diffuse optical method; they can even be tracked during neoadjuvant chemotherapy. Our proposed work emphasizes hardware and software improvements, and then pushes for more and deeper clinical studies. In particular we will upgrade the source switching apparatus and detection CCD in order to improve speed by approximately a factor of 4. This will increase our spectral coverage by approximately 4, given the same measurement time. We will upgrade the breast table to improve our idefinition of tissue boundaries and increase our sensitivity to breast tissue near the chest wall. We will upgrade our software for reconstruction in many ways, but most importantly in ways that reduce artifacts near boundaries. We will continue pilot studies on normal subjects and tumor bearing patients, this time with more specific supporting information from radiologists and pathologists, and finally, we will have a unique opportunity to follow a group of patients undergoing neoadjuvant chemotherapy. If successful, these powerful new improvements will enhance the fidelity of the breast images, and the anatomical and functional information generated by the device will improve our ability to detect and specify the nature of breast tumors.

描述（由申请人提供）： 这种竞争性延续赠款的远距离目标是评估和改善弥漫性光学层析成像的乳腺肿瘤诊断能力，并近红外光。近红外弥漫性光学断层扫描基于功能过程的研究，并提供了一些独特的可测量参数，具有增强乳腺肿瘤敏感性和特异性的潜力。利用非电离辐射的技术是非侵入性的，并且在技术上很简单，快速。组织光吸收系数可提供血液动力学，总血红蛋白浓度，血氧饱和度，水浓度和脂质含量。这些组织特性在迅速生长的肿瘤中通常大不相同。在此提案周期中，我们组装了一个平行板软压设备，用于乳房的弥漫性光学断层扫描，我们已经开始使用宾夕法尼亚大学医院的仪器进行试验临床研究。我们的试点研究清楚地表明，肿瘤是可检测到的，可通过弥漫性光学方法进行特征。在新辅助化疗期间，甚至可以跟踪它们。我们提出的工作强调了硬件和软件改进，然后推动更多，更深入的临床研究。特别是我们将升级源开关设备和检测CCD，以提高速度约4倍。给定时间相同的测量时间，这将使我们的光谱覆盖率大约增加4个。我们将升级乳房桌，以改善组织边界的界限，并提高我们对胸壁附近乳腺组织的敏感性。我们将在许多方面升级用于重建的软件，但最重要的是，以减少近乎边界的伪像的方式。我们将继续对正常受试者和肿瘤患者进行试验研究，这次是来自放射科医生和病理学家的更具体的支持信息，最后，我们将有一个独特的机会跟随接受新辅助化学疗法的一组患者。如果成功的话，这些强大的新改进将增强乳房图像的保真度，并且该设备产生的解剖和功能信息将提高我们检测和指定乳腺肿瘤的性质的能力。