A Unified Surgical Instrument System for Periodontal Minimally Invasive Surgery

牙周微创手术统一手术器械系统

• 批准号: 7269227
• 负责人: Stephen K. Harrel
• 金额: $ 10万
• 依托单位: DENTAL DESIGNS OF DALLAS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7269227
• 关键词: Adoption; Adult; Allografting; American; Autologous Transplantation; Biomedical Engineering; Bone Growth; Bone Transplantation; Cardiovascular Diseases; Cataract; Chronic; Clinical; Debridement; Dental; Dentistry; Development; Devices; Endoscopes; Esthetics; Evaluation; Goals; Growth; Human; Imagery; Inflammatory; Invasive; Journals; Laboratories; Legal patent; Medical; Medicine; Methods; Modification; Morbidity - disease rate; Natural regeneration; Operative Surgical Procedures; Optics; Organ Transplantation; Paper; Patients; Performance; Periodontal Diseases; Periodontic specialty; Personal Communication; Personal Satisfaction; Phase; Phase I Clinical Trials; Placement; Postoperative Pain; Procedures; Publishing; Purpose; Recombinants; Reporting; Research; Score; Site; Speed; Surgeon; Surgical Instruments; Surgical incisions; System; Techniques; Technology; Time; Tissues; Tooth Loss; Tooth structure; Trauma; Ultrasonics; Water; Work; base; bone; bone loss; bone morphogenic protein; concept; design; desire; enamel matrix proteins; evaluation/testing; improved; instrument; instrumentation; pressure; productivity loss; prototype; research clinical testing; soft tissue; success; treatment site; wound; Adoption; Adult; Allografting; American; Autologous Transplantation; Biomedical Engineering; Bone Growth; Bone Transplantation; Cardiovascular Diseases; Cataract; Chronic; Clinical; Debridement; Dental; Dentistry; Development; Devices; Endoscopes; Esthetics; Evaluation; Goals; Growth; Human; Imagery; Inflammatory; Invasive; Journals; Laboratories; Legal patent; Medical; Medicine; Methods; Modification; Morbidity - disease rate; Natural regeneration; Operative Surgical Procedures; Optics; Organ Transplantation; Paper; Patients; Performance; Periodontal Diseases; Periodontic specialty; Personal Communication; Personal Satisfaction; Phase; Phase I Clinical Trials; Placement; Postoperative Pain; Procedures; Publishing; Purpose; Recombinants; Reporting; Research; Score; Site; Speed; Surgeon; Surgical Instruments; Surgical incisions; System; Techniques; Technology; Time; Tissues; Tooth Loss; Tooth structure; Trauma; Ultrasonics; Water; Work; base; bone; bone loss; bone morphogenic protein; concept; design; desire; enamel matrix proteins; evaluation/testing; improved; instrument; instrumentation; pressure; productivity loss; prototype; research clinical testing; soft tissue; success; treatment site; wound

DESCRIPTION (provided by applicant): This effort is aimed at developing an effective, easily utilized, and unified system for performing periodontal minimally invasive surgery. Periodontal minimally invasive surgery (MIS) is a method for regenerating lost bone and tooth support resulting from periodontal disease.2-6 MIS utilizes much smaller incisions than traditional periodontal surgery, has a record of clinical regeneration of lost tissue, results in less patient trauma, less postoperative pain, better post surgical esthetics, and a more rapid return to normal function. Periodontal minimally invasive surgery is currently in use but no surgical instrument system exists that allows a surgeon to easily incorporate MIS into their surgical routine. The development of a unified MIS instrument system will consist of: (1) The fabrication of an endoscope visualization system that overcomes the clinical difficulties encountered with current visualization systems and (2) the fabrication of instruments for improved soft tissue debridement through the small surgical opening used with MIS. The long term goal is to produce a commercially available unified surgical instrument system for performing MIS. This system will allow the surgeon to easily perform MIS and will bring to the patient the advantages of MIS. The commercial potential for such a system is very high because of patient desire for the smallest and least invasive surgery possible. The commercial potential will expand as new bioengineered materials, currently under development, become available. The Phase 1 effort will build on existing bench top prototypes developed by Dental Designs of Dallas. Flexible medical endoscopes will be modified for use in MIS. Methods for soft tissue debridement will be developed by completely redesigning the currently available instrumentation (D'granulator, patent held by Dental Designs of Dallas) and the adaptation of medical ultrasonic "chopper" technology (Phacoemulsifier for cataracts). The developed prototypes will be evaluated in the laboratory by a group of periodontal surgical consultants who currently use MIS or who are leading, published, periodontal surgeons. The resulting system, based on the surgical consultants evaluations and scores, will be used in a Phase 2 multicenter controlled clinical evaluation of MIS.

描述（由申请人提供）：这项工作旨在开发一种有效，易于使用且统一的系统，用于进行牙周侵袭性手术。牙周侵入性手术（MIS）是一种通过牙周疾病再生骨骼和牙齿支撑的方法。2-6MIS比传统的牙周手术使用的切口要小得多，记录了失去组织临床再生的记录，导致患者创伤较少，导致较少的患者创伤，较少的术后术后手术后的手术后can术恢复更快，并更快地恢复了正常功能和正常功能。目前正在使用牙周最小的侵入性手术，但没有外科手术仪器系统可以使外科医生轻松地将MIS纳入其手术常规。统一MIS仪器系统的开发将包括：（1）内窥镜可视化系统的制造，该系统克服了当前可视化系统所遇到的临床困难，以及（2）通过与MIS一起使用的小型潮汐开放量改善软组织杂物的工具的制造。长期目标是生产商用统一的手术仪器系统来执行MIS。该系统将允许外科医生轻松执行MIS，并将MIS的优势带给患者。由于患者对可能的最小和最少侵入性手术的渴望，这种系统的商业潜力非常高。随着目前正在开发的新生物工程材料的可用性，商业潜力将扩大。第一阶段的工作将基于达拉斯牙科设计开发的现有基准顶部原型。灵活的医疗内窥镜将被修改以用于MIS。软组织清创术的方法将通过完全重新设计当前可用的仪器（D'Ranulator，由达拉斯牙科设计持有的专利）和医学超声“斩波器”技术（用于白内障的Phacoulsifier）的适应来开发。开发的原型将在实验室中评估一组牙周手术顾问，这些牙周手术顾问目前使用MIS或领导，出版，牙周外科医生。基于手术顾问评估和得分的最终系统将用于MIS的2阶段多中心控制的临床评估。