Ambient Air Pollution, Preeclampsia, and Preterm Delivery

环境空气污染、先兆子痫和早产

基本信息

批准号：
7252450
负责人：
MICHELLE A. WILLIAMS
金额：
$ 26.25万
依托单位：
SWEDISH MEDICAL CENTER, FIRST HILL
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-01 至 2009-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7252450
关键词：
Affect Air Air Pollutants Air Pollution Biological Biological Assay Biological Markers Blood specimen C-reactive protein Caliber Carbon Monoxide Carboxyhemoglobin Cardiovascular Diseases Cessation of life Characteristics Cities Cohort Studies Congenital Abnormality Daily Data Data Collection Databases Developed Countries Developing Countries Development Diagnostic Disease Disease Association Disease regression Enrollment Environmental Tobacco Smoke Exposure to Fetal Growth Fetal Growth Retardation Health Human Incidence Individual Indoor Air Pollution Infant Inflammation Intervention Knowledge Lead Link Lipid Peroxidation Literature Logistic Regressions Low Birth Weight Infant Maternal Mortality Measures Mediating Medical Medical Technology Modeling Morbidity - disease rate Outcome Oxidative Stress Participant Particulate Particulate Matter Perinatal Physiological Policies Population Population Characteristics Pre-Eclampsia Pregnancy Pregnancy Outcome Premature Birth Premature Infant Procedures Registries Reporting Research Design Research Personnel Risk Risk Factors Science Serum Source Standards of Weights and Measures Testing Thiobarbituric Acid Reactive Substances United States Weather Woman base cysteine rich protein improved member model design mortality neonatal morbidity programs prospective residence trafficking

项目摘要

DESCRIPTION (provided by applicant): Preeclampsia and preterm delivery are important causes of maternal and infant morbidity and mortality. Recent studies suggest that elevated air pollutant exposures may lead to preterm delivery, even at air pollutant levels typical of those in many US cities. No prior studies have directly examined air pollutant exposure in relation to preeclampsia; although much evidence suggests that the relation is biologically plausible. This study is based on a source population of women participating in a large cohort study. Participants enroll during early pregnancy and are followed until delivery. We will design models that use local traffic, weather, and population characteristics to predict monthly ambient concentrations of fine particulate matter (PM2.5) and carbon monoxide (CO). These models will be used to estimate study participants' PM2.5 and CO exposures before and during pregnancy. We will test whether these air pollutant exposures are associated with subsequent risk of preeclampsia and preterm delivery using multivariable logistic regression procedures. Additionally, we will test biological markers of maternal lipid peroxidation (thiobarbituric acid reactive substances) and inflammation (high sensitivity C-reactive protein) in maternal blood samples drawn during early pregnancy. We will use multivariable regression to examine lipid peroxidation and inflammation as biological mechanisms in air pollutant/disease relationships. We will also examine carboxyhemoglobin measured in early-pregnancy maternal blood samples as a marker of CO exposure. We will test the associations between carboxyhemoglobin and the pregnancy outcomes. Study results could contribute to knowledge regarding the causes and mechanisms involved in preeclampsia and preterm delivery. Such knowledge may have significance in developing preventative interventions for these two common adverse outcomes. The results could also contribute to the body of heath-related science that influences air quality standards and policies.

描述（由申请人提供）：先兆子痫和早产是孕产妇和婴儿发病率和死亡率的重要原因。最近的研究表明，即使在许多美国城市的空气污染物水平上，空气污染物的暴露率升高也可能导致早产。没有先前的研究直接检查了与先兆子痫有关的空气污染物的暴露。尽管大量证据表明这种关系在生物学上是可行的。这项研究基于参加大型队列研究的妇女的来源人群。参与者在怀孕初期就读，直到分娩为止。我们将设计使用当地交通，天气和人口特征的模型来预测每月的精细颗粒物（PM2.5）和一氧化碳（CO）的环境浓度。这些模型将用于估计参与者的PM2.5和CO在怀孕之前和期间的CO暴露。我们将测试这些空气污染物暴露于随后使用多变量逻辑回归程序的先兆子痫和早产的风险有关。此外，我们将测试在妊娠早期提取的母体血液样本中，在妊娠早期提取的孕产妇脂质过氧化（硫巴比妥酸反应性物质）和炎症（高灵敏度C反应蛋白）的生物学标志物。我们将使用多变量回归来检查脂质的过氧化和炎症作为空气污染物/疾病关系中的生物学机制。我们还将研究在早期孕妇孕妇血液样本中测量的羧基血红蛋白，作为CO暴露的标志。我们将测试羧基血红蛋白与妊娠结局之间的关联。研究结果可能有助于了解先兆子痫和早产涉及的原因和机制。这种知识可能在为这两种常见的不良结果开发预防干预措施方面具有重要意义。结果还可能有助于影响荒地相关的科学体系，从而影响空气质量标准和政策。