Sensitivity Enhancement in Nuclear Magnetic Resonance (NMR) by Para-hydrogen Induced Hyperpolarization (SenseNMR)

通过仲氢诱导超极化 (SenseNMR) 增强核磁共振 (NMR) 灵敏度

• 批准号: 2885315
• 金额: --
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2885315
• 关键词: Sensitivity; Enhancement; Nuclear; Magnetic; Resonance

Nuclear magnetic resonance (NMR) is one of the most powerful techniquesfor investigating the structure, composition, and dynamics of living andnon-living matter. Despite its widespread applications underlying lowsensitivity remains the achilles heel of the technique. Traditionally,highly expensive superconducting magnets in conjunction with exceedinglylong scan times are required to alleviate the sensitivity challenge.However, with ever increasing uncertainty of liquid Helium availability,it has become clear that NMR must move towards sustainable options builtaround permanent magnets. Over the last decade, NMR based on suchsystems (known as benchtop NMR) has made significant progress andclearly reflects the future of NMR. Tthe magnetic field strengths of thebenchtop magnets (~1 Tesla) are still though an order of magnitude lowerthan those of conventional superconducting magnets. Unfortunately thismeans they are categorized by even poorer sensitivity and meant for evenlonger scan times which can run into days for a single sample.In this project we will address both the long standing issues ofsensitivity and high cost associated with NMR spectroscopy. This willinvolve the application of a technique called hyperpolarization. Thisstudentship will employ the novel SABRE, and recently developedSABRE-Relay methods to achieve the spin hyperpolarization of the mostimportant nuclei including 1H, 13C, 15N, 19F and 31P which feature in anarray of important target molecules - chemical markers, agents,metabolites, drugs etc. Subsequently, these hyperpolarized targets willbe employed for a range of NMR applications from rapid chemicalidentification, tracking chemical fate, sample purity analysis andkinetic studies. Novel analytical and NMR methodologies will bedeveloped to achieve these goals in conjunction with novelinstrumentation and automation protocols.

核磁共振（NMR）是研究生物和新生物的结构，组成和动力学最强大的技术之一。尽管其基础的低敏性仍然是该技术的致命弱点。传统上，非常昂贵的超导磁铁与非常长的扫描时间相结合以减轻敏感性挑战。但是，随着液体氦气可用性的不确定性的越来越大，NMR显然必须朝着可持续的期权迈向建立的可持续选择。在过去的十年中，基于此类系统（称为台式NMR）的NMR取得了重大进展，并明确反映了NMR的未来。 The Benchtop磁铁（〜1 Tesla）的磁场强度仍然是传统超导磁体的较低数量级。不幸的是，这意味着他们的敏感性甚至更差，并且用于均匀的扫描时间，这可能会使单个样本持续到几天中。在这个项目中，我们将解决与NMR光谱相关的长期存在的问题和高成本。这将应用一种称为超极化的技术的应用。 Thisstudentship will employ the novel SABRE, and recently developedSABRE-Relay methods to achieve the spin hyperpolarization of the mostimportant nuclei including 1H, 13C, 15N, 19F and 31P which feature in anarray of important target molecules - chemical markers, agents,metabolites, drugs etc. Subsequently, these hyperpolarized targets willbe employed for a range of NMR applications from rapid chemicalidentification, tracking chemical命运，样品纯度分析和运动研究。新颖的分析方法和NMR方法将与NoveInstrumentation和Automation协议结合使用，以实现这些目标。