Sensitivity Enhancement in Nuclear Magnetic Resonance (NMR) by Para-hydrogen Induced Hyperpolarization (SenseNMR)

通过仲氢诱导超极化 (SenseNMR) 增强核磁共振 (NMR) 灵敏度

• 批准号: 2885315
• 金额: --
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2885315
• 关键词: Sensitivity; Enhancement; Nuclear; Magnetic; Resonance

Nuclear magnetic resonance (NMR) is one of the most powerful techniquesfor investigating the structure, composition, and dynamics of living andnon-living matter. Despite its widespread applications underlying lowsensitivity remains the achilles heel of the technique. Traditionally,highly expensive superconducting magnets in conjunction with exceedinglylong scan times are required to alleviate the sensitivity challenge.However, with ever increasing uncertainty of liquid Helium availability,it has become clear that NMR must move towards sustainable options builtaround permanent magnets. Over the last decade, NMR based on suchsystems (known as benchtop NMR) has made significant progress andclearly reflects the future of NMR. Tthe magnetic field strengths of thebenchtop magnets (~1 Tesla) are still though an order of magnitude lowerthan those of conventional superconducting magnets. Unfortunately thismeans they are categorized by even poorer sensitivity and meant for evenlonger scan times which can run into days for a single sample.In this project we will address both the long standing issues ofsensitivity and high cost associated with NMR spectroscopy. This willinvolve the application of a technique called hyperpolarization. Thisstudentship will employ the novel SABRE, and recently developedSABRE-Relay methods to achieve the spin hyperpolarization of the mostimportant nuclei including 1H, 13C, 15N, 19F and 31P which feature in anarray of important target molecules - chemical markers, agents,metabolites, drugs etc. Subsequently, these hyperpolarized targets willbe employed for a range of NMR applications from rapid chemicalidentification, tracking chemical fate, sample purity analysis andkinetic studies. Novel analytical and NMR methodologies will bedeveloped to achieve these goals in conjunction with novelinstrumentation and automation protocols.

核磁共振 (NMR) 是研究生命和非生命物质的结构、组成和动力学的最强大的技术之一。尽管其应用广泛，但低灵敏度仍然是该技术的致命弱点。传统上，需要昂贵的超导磁体和极长的扫描时间来缓解灵敏度挑战。然而，随着液氦可用性的不确定性不断增加，很明显，核磁共振必须转向围绕永磁体构建的可持续选择。在过去的十年中，基于此类系统的核磁共振（称为台式核磁共振）取得了重大进展，并清楚地反映了核磁共振的未来。台式磁体的磁场强度（约 1 特斯拉）仍然比传统超导磁体低一个数量级。不幸的是，这意味着它们的灵敏度更差，扫描时间更长，单个样品可能需要数天。在这个项目中，我们将解决与 NMR 波谱相关的长期存在的灵敏度和高成本问题。这将涉及一种称为超极化的技术的应用。该学生将采用新颖的 SABRE 和最近开发的 SABRE-Relay 方法来实现最重要的原子核的自旋超极化，包括 1H、13C、15N、19F 和 31P，这些原子核在一系列重要的目标分子中 - 化学标记物、试剂、代谢物、药物等随后，这些超极化靶材将用于一系列 NMR 应用，包括快速化学鉴定、跟踪化学命运、样品纯度分析。和动力学研究。将开发新的分析和核磁共振方法，以结合新的仪器和自动化协议来实现这些目标。