Assessment of Vascular Function in Hypertensive Children

高血压儿童的血管功能评估

• 批准号: 6884937
• 负责人: KAREN MCNIECE REDWINE
• 金额: $ 5.49万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6884937
• 关键词: adolescence (12-20); biomarker; blood pressure; cardiovascular function; child (0-11); clinical research; elasticity; glaucoma test; human subject; hypertension; obesity; pediatrics; postdoctoral investigator; statistics /biometry; vascular endothelium; vasodilatation

DESCRIPTION (provided by applicant): Hypertension with its related comorbidities is one of the leading causes of death in the US. While it takes years for hard endpoints such as stroke and heart attack to occur, it has become clear that this disease process begins much earlier in life. The prevalence of hypertension and obesity among our nation's children has increased significantly over the last decade leading to questions regarding treatment and long term outcomes in this patient population. Conventional endpoints are of little value in children so focus has turned to surrogate markers such as left ventricular hypertrophy, carotid artery intimal medial thickness, and microabluminuria. This study's aim is to better define the relationship between hypertension and functional vascular abnormalities - specifically brachial artery flow mediated dilatation and small and large vessel arterial compliance as measured by radial pulse wave contour analysis. By measuring these parameters in hypertensive children stratified according to severity of hypertension and matched controls, we plan to show that endothelial dependent vasodilatory response is depressed dependent on the severity of hypertension and that compliance in both small and large arteries in decreased accordingly.

描述（由申请人提供）： 高血压及其相关合并症是美国的主要原因之一。虽然中风和心脏病等硬终点的发生需要数年时间，但很明显，这种疾病过程在生命早期就开始了。过去十年来，我国儿童中高血压和肥胖症的患病率显着增加，导致对该患者群体的治疗和长期结果产生疑问。传统终点对儿童没有什么价值，因此焦点转向替代指标，如左心室肥厚、颈动脉内膜中层厚度和微量白蛋白尿。本研究的目的是更好地定义高血压与功能性血管异常之间的关系，特别是通过径向脉搏波轮廓分析测量的肱动脉血流介导的扩张以及小血管和大血管动脉顺应性。通过测量根据高血压严重程度分层的高血压儿童和匹配对照的这些参数，我们计划表明内皮依赖性血管舒张反应根据高血压的严重程度而降低，并且小动脉和大动脉的顺应性相应降低。