Ventricular Restraint Therapy for Heart Failure

心力衰竭的心室约束治疗

• 批准号: 6999037
• 负责人: RAVI K GHANTA
• 金额: $ 5.71万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2007-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6999037
• 关键词: auxiliary heart prosthesis; bioengineering /biomedical engineering; biomedical equipment development; biomedical equipment safety; cardiac myocytes; clinical biomedical equipment; disease /disorder model; echocardiography; fibrosis; heart contraction; heart failure; heart surgery; heart ventricle; hemodynamics; idiopathic dilated cardiomyopathy; intracardiac pressure; medical implant science; myocardium; oxygen consumption; pericardium; postdoctoral investigator; sheep

DESCRIPTION (provided by applicant): The major hypothesis of this proposal is that ventricular restraint therapy reduces transmural pressure, end-diastolic volume, and myocardial oxygen consumption to promote reverse remodeling in a dilated failing heart. Prior animal and initial clinical studies demonstrate the promise and feasibility of ventricular restraint therapy, however many questions remain. Our lab has developed a novel ventricular restraint device capable of quantitative ventricular restraint through the use of an epicardial balloon. Our first specific aim is to measure transmural pressure and left ventricular volume throughout the cardiac cycle, derive the pressure-volume relationship and calculate the pressure-volume area using quantitative ventricular restraint in a normal ovine heart. This aim will demonstrate the effect of ventricular restraint on ventricular mechanics and energetics in a normal heart. We will also examine the acute effect of ventricular restraint on myocardial perfusion. Our second aim is to perform these same measurements in an ovine post-infarcted model of dilated cardiomyopathy. We will perform serial measurements over a 3-month longitudinal study to evaluate end-diastolic volume, ventricle contractility, myocardial perfusion, and evidence of reverse remodeling in ventricular restraint versus control animals. Successful completion of these aims will, lead to a better understanding of the effect of ventricular restraint on ventricular physiology.

描述（由申请人提供）：该提案的主要假设是心室约束治疗可降低跨壁压、舒张末期容积和心肌耗氧量，以促进扩张的衰竭心脏的逆重塑。先前的动物和初步临床研究证明了心室约束治疗的前景和可行性，但仍然存在许多问题。我们的实验室开发了一种新型心室约束装置，能够通过使用心外膜球囊来定量心室约束。我们的第一个具体目标是测量整个心动周期的跨壁压和左心室容积，推导出压力-容积关系，并使用正常羊心脏的定量心室抑制计算压力-容积面积。该目标将证明心室约束对正常心脏心室力学和能量学的影响。我们还将检查心室抑制对心肌灌注的急性影响。我们的第二个目标是在绵羊梗塞后扩张型心肌病模型中进行相同的测量。我们将在为期 3 个月的纵向研究中进行系列测量，以评估心室抑制与对照动物的舒张末期容积、心室收缩力、心肌灌注以及逆重塑的证据。成功完成这些目标将有助于更好地理解心室抑制对心室生理学的影响。