fMRI STUDIES OF EMOTIONAL CIRCUITRY IN DEPRESSION

抑郁症情绪循环的功能磁共振成像研究

• 批准号: 6917272
• 负责人: YVETTE I SHELINE
• 金额: $ 50.67万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6917272
• 关键词: amygdala; antidepressants; bioimaging /biomedical imaging; brain mapping; cingulate gyrus; clinical research; cognition; emotions; face expression; functional magnetic resonance imaging; human middle age (35-64); human subject; major depression; neural information processing; neuroanatomy; neuropathology; patient oriented research; prefrontal lobe /cortex; sertraline; short term memory; young adult human (21-34)

DESCRIPTION (provided by applicant): Patients with recurrent major depression have abnormalities in a broad array of emotional and cognitive functions. Recently functional imaging studies have developed emotional tasks to elicit brain activation responses under standardized conditions. These studies implicate a circuit including the amygdala, the affective division of the anterior cingulate (ACad) and dorsolateral prefrontal cortex (DLPFC) in emotional regulation. The amygdala detects critical emotional information, especially threats. The ACad assesses salience of motivational cues, particularly based on amygdala input, detects conflict and regulates emotional responses. The DLPFC has a critical role in supporting a wide range of cognitive control functions. The goal of the current project is to determine which elements of the emotional circuit are dysfunctional in major depression. We propose to use functional magnetic resonance imaging (fMRI) in depressed (n = 50) and matched control (n = 50) subjects studied before and after a course of antidepressant treatment. We will use two standard cognitive paradigms in which emotion is manipulated to help elucidate the cognitive-emotional interace: a 2-back emotional working memory task and a matching task producing emotional conflict. We will determine whether depression involves a primary dysfunction in amygdala, ACad, or DLPFC. In addition, we hypothesize that depressed subjects will have normalization of abnormal brain activation with treatment. The proposed study has the potential to substantially advance our understanding of the precise nature and mechanisms underlying cognitive-emotional dysregulation in major depression.

描述（由申请人提供）：复发性重度抑郁症患者在多种情绪和认知功能上存在异常。最近的功能成像研究开发了情感任务，以在标准化条件下引发大脑激活反应。这些研究表明，情绪调节中存在一个回路，包括杏仁核、前扣带回情感区（ACad）和背外侧前额叶皮层（DLPFC）。杏仁核检测关键的情绪信息，尤其是威胁。 ACAD 评估动机线索的显着性，特别是基于杏仁核输入，检测冲突并调节情绪反应。 DLPFC 在支持广泛的认知控制功能方面发挥着关键作用。当前项目的目标是确定情绪回路的哪些元素在重度抑郁症中出现功能障碍。我们建议在抗抑郁治疗前后对抑郁症（n = 50）和匹配对照（n = 50）受试者使用功能磁共振成像（fMRI）。我们将使用两种标准的认知范式，其中情绪被操纵以帮助阐明认知-情绪相互作用：2-back情绪工作记忆任务和产生情绪冲突的匹配任务。我们将确定抑郁症是否涉及杏仁核、ACAD 或 DLPFC 的原发性功能障碍。此外，我们假设抑郁症受试者通过治疗可以使异常的大脑激活正常化。拟议的研究有可能大大增进我们对重度抑郁症认知情绪失调的确切性质和机制的理解。