Infancy to Adolescence: fMRI and Risk for Anxiety Disorder

婴儿期到青春期：功能磁共振成像和焦虑症风险

基本信息

批准号：
7210959
负责人：
CARL E SCHWARTZ
金额：
$ 2.91万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2008-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7210959
关键词：
18 year old AVPR1A gene Address Adolescence Adolescent Adolescent Development Age Age-Months Age-Years Amygdaloid structure Anger Animals Anxiety Anxiety Disorders Behavioral Behavioral inhibition Biological Brain Brain imaging CRH gene Candidate Disease Gene Child Childhood Chronic Class Classification Corticotropin-Releasing Hormone Crying Data Development Diagnostic Disease Economics Emotional Enrollment Environmental Risk Factor Etiology Face Family Functional Magnetic Resonance Imaging Funding Genes Genetic Genetic Polymorphism Grant HTR3A gene High Prevalence Human Human Genetics Image Impairment Individual Infant Insula of Reil Laboratories Life Measures Mental disorders Morbidity - disease rate Motor Activity Mus Neurobiology Parahippocampal Gyrus Pattern Phenotype Phobic anxiety disorder Population Study Positioning Attribute Predisposition Prefrontal Cortex Prevention Prevention strategy Principal Investigator Probability Protocols documentation Psychology Psychophysiology RGS2 gene Research Research Personnel Resources Risk Risk Factors Sampling Signal Transduction Social Development Social Phobia Stimulus Superior temporal gyrus Susceptibility Gene Symptoms System TDO2 gene Temperament Testing Toddler Tryptophanase Twin Studies Work base burden of illness cohort cost critical developmental period early childhood early onset emotional stimulus endophenotype follow-up gene function genetic analysis genetic association genetic variant hippocampus uncus human RGS2 protein infancy infant temperament insight neuroimaging novel parent project psychologic research study response social social cognition social neuroscience trait translational study

项目摘要

DESCRIPTION (provided by applicant): This is a request for as supplement to add genetics studies to the funded R01 From Infancy to Adolescence: FMRI and Risk for Anxiety Disorder. This ongoing study centers on adolescence as a critical period of risk for development of mental disorders, and will follow up a well-characterized cohort to 1) test hypotheses regarding the relation between temperamental types observed in infancy and toddlerhood and the subsequent development of adolescent psychiatric disorder, particularly social anxiety disorder (SAD); 2) investigate whether temperamental types predict differences in regional brain activation measured with fMRI, particularly amygdala and RFC, at adolescence; 3) compare within the group of adolescents known to have early temperaments that predispose to the development of SAD, patterns of regional brain activation in adolescents who did and did not develop SAD. This translational study therefore lies at the junction of social neuroscience, psychology. The study population represents an unique resource, having been carefully char- acterized in early infancy and followed though adolescence, using both detailed psychological and biological assessments.Social phobia presents among psychiatric disorders an unusual combination of almost universal early onset in childhood or early adolescence, high prevalence, chronic impairment with a 50% risk of continuing into adulthood for a median duration of 25 years, risk of secondary co-morbidity, and low probability of treatment. Previous research by our group and others has compellingly implicated several genes and biological systems in behavioral and brain phenotypes related to Bl and social anxiety.This cohort provides an opportunity to address the genetic basis for temperamental high reactivity and Bl, and the risk for SAD that is unlikely to be repeated. By examining behavioral and biological intermediate phenotypes (temperament and functional brain imaging) that may be more proximal expressions of gene function, we are in a unique position to examine the influence of genes on the risk for social anxiety disorder. Although previous small studies have examined polymorphisms and candidate genes in fMRI studies of amygdala reactivity, none has included a longitudinal cohort for which early childhood temperament assessments and psychiatric assessments have been collected. Because the phenotypic data has been separately funded, this application will represent a highly cost-effective effort to supplement these efforts with genetic analyses.

描述（由申请人提供）：这是向从婴儿期到青春期的资助R01添加遗传学研究的补充要求：fMRI和焦虑症的风险。这项正在进行的研究以青春期为中心，这是精神障碍发展的关键时期，并将跟进特征良好的队列至1）关于婴儿期和幼儿园中气质类型的关系以及随后发展的青少年精神障碍，尤其是社交焦虑症（尤其是社交焦虑症（SAD））的测试假设； 2）调查气质类型是否可以预测青春期在fMRI，尤其是杏仁核和RFC测量的区域大脑激活的差异； 3）比较在已知的早期气质的群体中比较，这种气质倾向于发展，而在做过也没有发展SAD的青少年中，SAD，区域大脑激活的模式。因此，这项翻译研究在于社会神经科学，心理学的结合。 The study population represents an unique resource, having been carefully char- acterized in early infancy and followed though adolescence, using both detailed psychological and biological assessments.Social phobia presents among psychiatric disorders an unusual combination of almost universal early onset in childhood or early adolescence, high prevalence, chronic impairment with a 50% risk of continuing into adulthood for a median duration of 25 years, risk of secondary合并症和治疗可能性较低。我们小组和其他人的先前研究令人着迷于与BL和社交焦虑有关的行为和大脑表型中的几个基因和生物系统。这一群体提供了解决气质高反应性和BL的遗传基础的机会，而SAD的风险不太可能重复。通过检查行为和生物学中间表型（气质和功能性脑成像），这可能是基因功能的近端表达，我们处于一个独特的位置，可以检查基因对社交焦虑症风险的影响。尽管先前的小型研究已经检查了杏仁核反应性的功能磁共振成像研究中的多态性和候选基因，但没有一个包括纵向队列的纵向队列，尚未收集儿童气质评估和精神病学评估。由于表型数据已被单独资助，因此该应用将代表一项高度成本效益的努力，以通过遗传分析来补充这些努力。