Infancy to Adolescence: fMRI and Risk for Anxiety Disorder

婴儿期到青春期：功能磁共振成像和焦虑症风险

基本信息

批准号：
7210959
负责人：
CARL E SCHWARTZ
金额：
$ 2.91万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2008-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7210959
关键词：
18 year old AVPR1A gene Address Adolescence Adolescent Adolescent Development Age Age-Months Age-Years Amygdaloid structure Anger Animals Anxiety Anxiety Disorders Behavioral Behavioral inhibition Biological Brain Brain imaging CRH gene Candidate Disease Gene Child Childhood Chronic Class Classification Corticotropin-Releasing Hormone Crying Data Development Diagnostic Disease Economics Emotional Enrollment Environmental Risk Factor Etiology Face Family Functional Magnetic Resonance Imaging Funding Genes Genetic Genetic Polymorphism Grant HTR3A gene High Prevalence Human Human Genetics Image Impairment Individual Infant Insula of Reil Laboratories Life Measures Mental disorders Morbidity - disease rate Motor Activity Mus Neurobiology Parahippocampal Gyrus Pattern Phenotype Phobic anxiety disorder Population Study Positioning Attribute Predisposition Prefrontal Cortex Prevention Prevention strategy Principal Investigator Probability Protocols documentation Psychology Psychophysiology RGS2 gene Research Research Personnel Resources Risk Risk Factors Sampling Signal Transduction Social Development Social Phobia Stimulus Superior temporal gyrus Susceptibility Gene Symptoms System TDO2 gene Temperament Testing Toddler Tryptophanase Twin Studies Work base burden of illness cohort cost critical developmental period early childhood early onset emotional stimulus endophenotype follow-up gene function genetic analysis genetic association genetic variant hippocampus uncus human RGS2 protein infancy infant temperament insight neuroimaging novel parent project psychologic research study response social social cognition social neuroscience trait translational study

项目摘要

DESCRIPTION (provided by applicant): This is a request for as supplement to add genetics studies to the funded R01 From Infancy to Adolescence: FMRI and Risk for Anxiety Disorder. This ongoing study centers on adolescence as a critical period of risk for development of mental disorders, and will follow up a well-characterized cohort to 1) test hypotheses regarding the relation between temperamental types observed in infancy and toddlerhood and the subsequent development of adolescent psychiatric disorder, particularly social anxiety disorder (SAD); 2) investigate whether temperamental types predict differences in regional brain activation measured with fMRI, particularly amygdala and RFC, at adolescence; 3) compare within the group of adolescents known to have early temperaments that predispose to the development of SAD, patterns of regional brain activation in adolescents who did and did not develop SAD. This translational study therefore lies at the junction of social neuroscience, psychology. The study population represents an unique resource, having been carefully char- acterized in early infancy and followed though adolescence, using both detailed psychological and biological assessments.Social phobia presents among psychiatric disorders an unusual combination of almost universal early onset in childhood or early adolescence, high prevalence, chronic impairment with a 50% risk of continuing into adulthood for a median duration of 25 years, risk of secondary co-morbidity, and low probability of treatment. Previous research by our group and others has compellingly implicated several genes and biological systems in behavioral and brain phenotypes related to Bl and social anxiety.This cohort provides an opportunity to address the genetic basis for temperamental high reactivity and Bl, and the risk for SAD that is unlikely to be repeated. By examining behavioral and biological intermediate phenotypes (temperament and functional brain imaging) that may be more proximal expressions of gene function, we are in a unique position to examine the influence of genes on the risk for social anxiety disorder. Although previous small studies have examined polymorphisms and candidate genes in fMRI studies of amygdala reactivity, none has included a longitudinal cohort for which early childhood temperament assessments and psychiatric assessments have been collected. Because the phenotypic data has been separately funded, this application will represent a highly cost-effective effort to supplement these efforts with genetic analyses.

描述（由申请人提供）：这是一项补充请求，旨在将遗传学研究添加到资助的 R01 从婴儿期到青春期：FMRI 和焦虑症风险中。这项正在进行的研究以青春期作为精神障碍发展风险的关键时期为中心，并将跟踪一个特征明确的队列，以：1）测试关于婴儿期和幼儿期观察到的气质类型与青少年精神病学随后发展之间关系的假设障碍，特别是社交焦虑症（SAD）； 2) 研究气质类型是否可以预测青少年时期通过功能磁共振成像（特别是杏仁核和 RFC）测量的区域大脑激活的差异； 3) 在已知具有易患 SAD 的早期气质的青少年群体中，比较发生和未发生 SAD 的青少年的区域大脑激活模式。因此，这项转化研究处于社会神经科学和心理学的交叉点。研究人群代表了一种独特的资源，通过详细的心理和生物学评估，在婴儿早期进行了仔细的表征，并在整个青春期进行了跟踪。社交恐惧症在精神疾病中呈现出一种不寻常的组合，几乎普遍在儿童期或青春期早期发病，患病率高，慢性损伤有 50% 的风险持续到成年，中位持续时间为 25 年，继发性共病的风险以及治疗概率低。我们小组和其他人之前的研究已经令人信服地暗示了与 Bl 和社交焦虑相关的行为和大脑表型中的几个基因和生物系统。该队列提供了一个机会来解决气质高反应性和 Bl 的遗传基础，以及 SAD 的风险不太可能重复。通过检查可能是基因功能更接近表达的行为和生物中间表型（气质和功能性脑成像），我们处于独特的地位来检查基因对社交焦虑症风险的影响。尽管之前的小型研究已经在杏仁核反应性的功能磁共振成像研究中检查了多态性和候选基因，但没有一项研究包括收集幼儿气质评估和精神病学评估的纵向队列。由于表型数据是单独资助的，因此该申请将代表一种极具成本效益的努力，通过遗传分析来补充这些努力。