Intraoperative Optical Imaging of Brain Function

脑功能的术中光学成像

• 批准号: 6852783
• 负责人: Andrew K Dunn
• 金额: $ 23.09万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-01 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6852783
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; blood volume; brain circulation; brain imaging /visualization /scanning; charge coupled device camera; clinical biomedical equipment; clinical research; hemodynamics; hemoglobin; human subject; image guided surgery /therapy; image processing; lasers; neurosurgery; optics; oxygen consumption; oxygen transport; time resolved data

DESCRIPTION (provided by applicant): During brain surgery it is critical to be able to assess cortical function in order to minimize resection of eloquent areas of the brain whenever possible: Although pre-operative functional magnetic resonance imaging (fMRI) is often used to define functional areas of the cortex, it does not provide the surgeon with real-time feedback during surgery, and interpretation of the BOLD fMRI signal can be difficult. The current standard for intraoperative functional mapping is electrocortical stimulation mapping with direct observation of 'ability disruption'. However, while this technique provides real-time feedback to the surgeon, it provides only coarse (approximately 1 cm), qualitative spatial assessment of cortical function. The goal of this proposal is to develop a dual CCD based optical imaging system capable of real-time quantitative imaging of brain function during neurosurgery by imaging changes in cerebral blood flow, blood volume, hemoglobin oxygenation and oxygen metabolism. To accomplish this, laser speckle contrast imaging will be combined with multi-wavelength reflectance imaging. We will develop, in Aim 1, a laser speckle contrast imaging instrument suitable for use within the operating room, and use the instrument to image the cerebral blood flow changes during somatosensory and motor stimulation in patients undergoing neurosurgery. We will also develop and implement improved algorithms for processing and filtering of speckle contrast images to enable real-time visualization of cerebral blood flow. In Aim 2 we will extent the capabilities of the imaging instrumentation to include multi-wavelength imaging of reflectance changes for quantitative imaging of hemoglobin volume and oxygenation changes. Together, these images will enable calculation of the stimulation-induced changes in oxygen metabolism. This unique instrument has the potential for high resolution, real-time intraoperative mapping of cortical function through multiple hemodynamic and metabolic parameters, with the potential to provide valuable guidance during neurosurgery.

描述（由申请人提供）： 在脑部手术期间，能够评估皮质功能至关重要，以便尽可能减少大脑功能区域的切除：虽然术前功能性磁共振成像 (fMRI) 通常用于定义皮质的功能区域，但无法在手术过程中为外科医生提供实时反馈，并且 BOLD fMRI 信号的解释可能很困难。目前术中功能标测的标准是直接观察“能力破坏”的皮层电刺激标测。然而，虽然该技术向外科医生提供实时反馈，但它仅提供皮质功能的粗略（约 1 厘米）定性空间评估。该提案的目标是开发一种基于双CCD的光学成像系统，能够通过对脑血流量、血容量、血红蛋白氧合和氧代谢的变化进行成像，对神经外科手术期间的脑功能进行实时定量成像。为了实现这一目标，激光散斑对比度成像将与多波长反射成像相结合。在目标1中，我们将开发一种适合在手术室内使用的激光散斑对比成像仪，并使用该仪器对接受神经外科手术的患者在体感和运动刺激期间的脑血流变化进行成像。我们还将开发和实施改进的算法来处理和过滤散斑对比度图像，以实现脑血流的实时可视化。在目标 2 中，我们将扩展成像仪器的功能，包括反射率变化的多波长成像，以实现血红蛋白体积和氧合变化的定量成像。总之，这些图像将能够计算刺激引起的氧代谢变化。这种独特的仪器有潜力通过多种血流动力学和代谢参数对皮质功能进行高分辨率、实时的术中测绘，并有可能在神经外科手术期间提供有价值的指导。